Effect of Exogenous Long-Chain Fatty Acids on Individual Fatty Acid Synthesis by Dispersed Ruminant Mammary Gland Cells

Hansen, H O; Knudsen, Jens

doi:10.3168/jds.s0022-0302(87)80155-8

Cited by 54 publications

(35 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most SFA are synthesized de novo within the mammary glands, and the synthesis is strongly regulated by activities of acetyl coenzyme A (CoA) carboxylase [8]. However, this is not the case for C18:0, which is derived from feed, and C16:0, which is synthesized in the mammary gland and derived from feed [14]. This explains the negative correlation between C18:0 and SFA and the positive correlation between C18:0 and UFA.…”

Section: Discussionmentioning

confidence: 99%

Genetic parameters for milk fatty acids in Danish Holstein cattle based on SNP markers using a Bayesian approach

et al. 2013

View full text Add to dashboard Cite

BackgroundFor several years, in human nutrition there has been a focus on the proportion of unsaturated fatty acids (UFA) and saturated fatty acids (SFA) found in bovine milk. The positive health-related properties of UFA versus SFA have increased the demand for food products with a higher proportion of UFA. To be able to change the UFA and SFA content of the milk by breeding it is important to know whether there is a genetic component underlying the individual FA in the milk. We have estimated the heritability for individual FA in the milk of Danish Holstein. For this purpose we used information of SNP markers instead of the traditional pedigree relationships.ResultsEstimates of heritability were moderate within the range of 0.10 for C18:1 trans-11 to 0.34 for C8:0 and C10:0, whereas the estimates for saturated fatty acids and unsaturated fatty acids were 0.14 and 0.18, respectively. Posterior standard deviations were in the range from 0.07 to 0.17. The correlation estimates showed a general pattern of two groups, one group mainly consisting of saturated fatty acids and one group mainly consisting of unsaturated fatty acids. The phenotypic correlation ranged from −0.95 (saturated fatty acids and unsaturated fatty acids) to 0.99 (unsaturated fatty acids and monounsaturated fatty acids) and the genomic correlation for fatty acids ranged from −0.29 to 0.91.ConclusionsThe heritability estimates obtained in this study are in general accordance with heritability estimates from studies using pedigree data and/or a genomic relationship matrix in the context of a REML approach. SFA and UFA expressed a strong negative phenotypic correlation and a weaker genetic correlation. This is in accordance with the theory that SFA is synthesized de novo, while UFA can be regulated independently from the regulation of SFA by the feeding regime.

show abstract

Section: Discussionmentioning

confidence: 99%

Genetic parameters for milk fatty acids in Danish Holstein cattle based on SNP markers using a Bayesian approach

et al. 2013

View full text Add to dashboard Cite

show abstract

“…More likely, however, is an additional effect of elements arising from either the abomasal infusates or the CaS on milk fat synthesis. Fatty acids other than trans-10, cis-12 CLA, such as palmitic and oleic acids, inhibit mammary lipogenesis allosterically (Hansen and Knudsen 1987;Wright et al 2002) while many fatty acids stimulate esterification and secretion into milk (Yang et al 1978;Hansen et al 1984). A difference between the two routes of CLA administration in delivery of other fatty acids could result in the dichotomy of D max values.…”

Section: Methodsmentioning

confidence: 99%

Milk production responses of primiparous and multiparous dairy cows to dose of conjugated linoleic acid consumed in rumen inert form

Sippel¹,

Spratt²,

Cant³

2009

Can. J. Anim. Sci.

View full text Add to dashboard Cite

Conjugated linoleic acid (CLA) has the potential to be used as a dietary means of manipulating milk fat production of dairy cows to meet specified short-term targets, as in a supply-managed industry. An experiment was conducted to evaluate the dose-response to calcium salts of CLA fed as a top-dress on a corn- and alfalfa-based TMR. In two 5 × 5 Latin squares of 28-d periods, five primiparous and five multiparous cows were fed 0, 22, 45, 67 or 178 g d-1 CLA (29% trans-10, cis-12) as a calcium salt. Results from one multiparous cow on the 178 g d-1 treatment were removed from statistical analysis because milk production fell to 1.2 kg d-1 by the end of the period. On average, milk, lactose and protein yields increased at the lower doses of CLA and decreased to control levels at the highest dose. Milk fat yield declined progressively from 876 to 770, 689, 676 and 543 g d-1 on the five doses. Net energy balance of cows increased linearly from -1.5 Mcal d-1 on the control to 2.0 Mcal d-1 at 178 g d-1 CLA. The percentage depression in milk fat yield at different doses of trans-10, cis-12 CLA was described by the equation y = 54/(1 + 22.8/dose). Comparison with published literature suggested that feeding calcium salts of CLA was 30% as effective in depressing milk fat production as an abomasal infusion, due to rumen biohydrogenation and intestinal indigestibility.Key words: Milk composition, cattle, diet

show abstract

“…These different lipogenic pathways are regulated in part by long-chain FA (including MUFA and PUFA) originating either from dietary FA absorption or from body fat mobilization, which decrease de novo FA synthesis [20,69,70]. Furthermore, a crucial role has been proposed recently for trans FA in milk fat depression ( [34], Shingfield and Griinari, this issue).…”

Section: Effects Of Rbh Intermediates On Mammary Lipogenesismentioning

confidence: 99%

Diet, rumen biohydrogenation and nutritional quality of cow and goat milk fat

Chilliard

Glasser

Ferlay

et al. 2007

Euro J Lipid Sci & Tech

743

102

786

View full text Add to dashboard Cite

Diet, rumen biohydrogenation and nutritional quality of cow and goat milk fatThe potential to modify the milk fatty acid (FA) composition by changing the cow or goat diets is reviewed. Ruminal biohydrogenation (RBH), combined with mammary lipogenic and D-9 desaturation pathways, considerably modifies the profile of dietary FA and thus milk composition. The pasture has major effects by decreasing saturated FA and increasing FA considered as favorable for human health (c9-18:1, 18:3n-3 and c9t11-CLA), compared to winter diets, especially those based on maize silage and concentrates. Plant lipid supplements have effects similar to pasture, especially linseed, but they increase to a larger extent, simultaneously several trans isomers of 18:1 and, conjugated or non-conjugated 18:2, especially when added to maize silage or concentrate-rich diets. The goat responds better for milk 18:3n-3 and c9t11-CLA, and sometimes less for c9-18:1, and is less prone to the RBH trans-11 to trans-10 shift, which has been shown to be time dependent in the cow. The respective physiological roles of most milk trans FA have not been studied to date, and more studies in rodents and humans fed dairy products modified by changing ruminant diet are required before recommending a larger use of lipid sources and how to combine them with the different feeding systems used by dairy farmers.Keywords: Diet composition, biohydrogenation intermediates, mammary metabolism, fatty acid desaturation, milk fatty acids. 828 DOI 10.1002/ejlt.200700080 Eur. J. Lipid Sci. Technol. 109 (2007 IntroductionMilk fat secretion and milk fatty acid (FA) composition are of great interest with regard to human nutrition. Apart from their contribution to dairy products' sensorial quality and to the amount of dietary energy, different lipid and FA compounds (short-and medium-chain saturated, branched, mono-and polyunsaturated, cis and trans, conjugated FA, etc.) present in ruminant milk fat are indeed potentially positive or negative factors for the health of consumers [1][2][3].Dairy products provide indeed 25-60% of the overall saturated fat consumption in Europe, which makes them, since decades, a target of dieticians' criticism due to the negative effects of excessive consumption of saturated FA on human health [4]. The image of saturated FA should, however, be weighed by the fact that C 12 -C 16 saturated FA are thought to be atherogenic only when consumed in excessive amounts, that 18:0 has no atherogenic effect and that saturated fat could even be protective when compared to a low-fat, high-carbohydrate diet [5,6]. The allegedly atherogenic effect of certain trans monounsaturated FA (MUFA) [7] has not been confirmed for vaccenic acid (t11-18:1), the main isomer present in milk [8,9]. The intake of some trans isomers of 18:2 seems to be particularly harmful, although further research is needed to discriminate between industrial and ruminant isomer profiles [10]. In other respects, it has been shown in humans that the consumption of milk fat [11] could sometimes d...

show abstract

Effect of Exogenous Long-Chain Fatty Acids on Individual Fatty Acid Synthesis by Dispersed Ruminant Mammary Gland Cells

Cited by 54 publications

References 12 publications

Genetic parameters for milk fatty acids in Danish Holstein cattle based on SNP markers using a Bayesian approach

Genetic parameters for milk fatty acids in Danish Holstein cattle based on SNP markers using a Bayesian approach

Milk production responses of primiparous and multiparous dairy cows to dose of conjugated linoleic acid consumed in rumen inert form

Diet, rumen biohydrogenation and nutritional quality of cow and goat milk fat

Contact Info

Product

Resources

About