Effect of exogenous melatonin on the onset of puberty in female albino rats

Batmanabane, Mounissamy; Ramesh, Kunnampilly Gopalkrishnan

doi:10.1002/(sici)1097-0185(199607)245:3<519::aid-ar8>3.3.co;2-w

Cited by 6 publications

(4 citation statements)

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“…Fowler and Racey [26] demonstrated that elevated melatonin level is important in the regulation of endogenous hormonal cycle in hedgehog during winter. The studies on rodents showed inhibitory effect of melatonin on ovarian function [27,28]. However, in contrast with the inhibitory effects in small rodents, melatonin stimulates gonadal function in sheep.…”

Section: Introductionmentioning

confidence: 99%

Melatonin affects steroidogenesis and delayed ovulation during winter in vespertilionid bat, Scotophilus heathi

Srivastava

Krishna

2010

The Journal of Steroid Biochemistry and Molecular Biology

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Section: Introductionmentioning

confidence: 99%

Melatonin affects steroidogenesis and delayed ovulation during winter in vespertilionid bat, Scotophilus heathi

Srivastava

Krishna

2010

The Journal of Steroid Biochemistry and Molecular Biology

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“…Melatonin has a variety of physiological actions such as control of circadian rhythms (Rednab et al 1983;McArthur et al 1997;Sack et al 2000), regulation of body temperature (Dollins et al 1994), hormone secretion influencing sexual development (Esquifino et al 1987;Batmanabane and Ramesh 1996) and the reproductive cycle in seasonally breeding animals (Kennaway and Rowe 1995), activation of immune system (Garcia-Mauriño et al 1997;Barjavel et al 1998;García-Mauriño et al 2000), anti-tumor activity (Hill and Blask 1988;Martínez-Campa et al 2006), free-radical scavenging and antioxidation (Eşrefoglu et al 2005;León et al 2005;Reiter et al 2003). In addition, melatonin was suggested to play an important physiolosical role in bone formation (Roth et al 1999;Satomura et al 2007) and tooth development (Kumasaka et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Expression and cellular localizaion of melatonin-synthesizing enzymes in rat and human salivary glands

Shimozuma

Tokuyama

Tatehara

et al. 2011

Histochem Cell Biol

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Melatonin, discovered in 1958, is secreted by the pineal gland primarily during the night. Its secretion is controlled by the light/dark cycle of the environment. Melatonin is also produced in and secreted by various extrapineal organs, tissues and cells and its synthesizing enzyme arylalkylamine N-acetyltransferase (AANAT) is expressed in various extrapineal organs, tissues and cells. Recently, it was reported that melatonin is present in saliva, but it is not certain where melatonin was synthesized and whether it was secreted into saliva and what function it may have in saliva. The present study was performed to investigate where melatonin was synthesized and whether it was secreted by salivary glands into saliva. We performed immunohistochemical analysis of the expression of AANAT in rat parotid, submandibular and sublingual glands and the expression of both AANAT and hydroxyindole-O-methyltransferase (HIOMT) in human submandibular glands. We evaluated the expression of AANAT and HIOMT mRNA in rat submandibular glands by quantitative reverse transcription-polymerase chain reaction. As a result, we observed expression of AANAT in epithelial cells of striated ducts in rat salivary glands and expression of AANAT, HIOMT and melatonin in epithelial cells of striated ducts in human submandibular glands. In addition, we also confirmed the expression of the most potent melatonin receptor, melatonin 1a receptor, in rat buccal mucosa. Our findings suggest that melatonin might be produced and secreted by salivary glands directly into saliva and that it might play some physiological role in the oral cavity.

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“…Its secretion is controlled by the light:dark cycle in such a manner that it is released in large amounts during the night, but only minimally during the day (Lynch et al 1987;Reiter 1991;Reiter et al 1996). Melatonin has a variety of physiological actions such as control of circadian rhythms (Redman et al 1983;McArthur et al 1997), regulation of body temperature (Dollins et al 1994), hormone secretion inXuencing sexual development (EsquiWno et al 1987;Batmanabane and Ramesh 1996) and the reproductive cycle in seasonally breeding animals (Kennaway and Rowe 1995), activation of the immune system (Garcia-Maurino et al 2000;Raghavendra et al 2001;Guerrero and Reiter 2002), and anti-tumor activity (Hill and Blask 1988;Martínez-Campa et al 2006;Sánchez-Barceló et al 2005). In addition, melatonin and its metabolites potentially exert anti-aging eVects due to its ability to function as a free radical scavenger and antioxidant (León et al 2005;Tan et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Possible involvement of melatonin in tooth development: expression of melatonin 1a receptor in human and mouse tooth germs

Kumasaka

Shimozuma

Kawamoto

et al. 2010

Histochem Cell Biol

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Melatonin is known to regulate a variety of physiological processes including control of circadian rhythms, regulation of seasonal reproductive function, regulation of body temperature, free radical scavenging, and so forth. Accumulating evidence from in vitro and in vivo experiments has also suggested that melatonin may have an inXuence on skeletal growth and bone formation. However, little is known about the eVects of melatonin on tooth development and growth, which thus remain to be elucidated. This study was performed to examine the possibility that melatonin might exert its inXuence on tooth development as well as skeletal growth. Immunohistochemical analysis revealed that melatonin 1a receptor (Mel1aR) was expressed in secretory ameloblasts, the cells of the stratum intermedium and stellate reticulum, external dental epithelial cells, odontoblasts, and dental sac cells. Reverse transcription-polymerase chain reaction and Western blot analysis showed that HAT-7, a rat dental epithelial cell line, expressed Mel1aR and its expression levels increased after the cells reached conXuence. These results strongly suggest that melatonin may play a physiological role in tooth development/growth by regulating the cellular function of odontogenic cells in tooth germs.

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Effect of exogenous melatonin on the onset of puberty in female albino rats

Cited by 6 publications

References 0 publications

Melatonin affects steroidogenesis and delayed ovulation during winter in vespertilionid bat, Scotophilus heathi

Melatonin affects steroidogenesis and delayed ovulation during winter in vespertilionid bat, Scotophilus heathi

Expression and cellular localizaion of melatonin-synthesizing enzymes in rat and human salivary glands

Possible involvement of melatonin in tooth development: expression of melatonin 1a receptor in human and mouse tooth germs

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