Effect of exposure to detergents and other chemicals on biomarkers of pulmonary response in exhaled breath from hospital cleaners: a pilot study

Abstract

The promising role of EBC analysis in biomonitoring of exposed workers was confirmed. It was also possible to identify the potential biomarkers of exposure to alkaline products (increased ammonium-EBC and pH-EBC levels) and potential biomarkers of oxidative stress (increased H(2)O(2)-EBC levels correlated with 4-HNE-EBC levels) in workers with no signs of airway diseases.

Contribution of exhaled nitric oxide measurement in airway inflammation assessment in asthma. A position paper from the French Speaking Respiratory Society

“…In baker and hairdresser apprentices followed during their training, the increase in exhaled NO was associated with the occurrence of non-specific bronchial hyperresponsiveness [77]. Exhaled NO measurement was not increased in hospital staff exposed to detergents compared to non-exposed hospital staff, whereas other biomarkers of inflammation and oxidative stress were increased in the first group compared to the second group, which could suggest an irritating rather than an allergic mechanism [78]. A study of baker and hairdresser apprentices aiming at comparing the efficacy of exhaled NO measurement versus spirometry on the monitoring of their respiratory health has shown that each test provides unique information on the respiratory system and allows identifying subjects requiring more extensive investigations [79].…”

“…Chez des apprentis boulangers et coiffeurs suivis pendant leur apprentissage, l'augmentation du NO expiré était associée à l'apparition d'une hyperréactivité bronchique non spécifique[77]. La mesure du NO expiré n'était pas augmentée chez des agents hospitaliers exposés à des détergents par rapport à des agents hospitaliers non exposés, alors que d'autres biomarqueurs d'inflammation et de stress oxydatif étaient augmentés dans le premier groupe par rapport au second, pouvant suggérer un mécanisme irritatif plutôt qu'allergique[78]. Une étude auprès d'apprentis boulangers et coiffeurs, visant à comparer la performance de la mesure du NO expiré et de la spirométrie dans la surveillance de leur santé respiratoire, a observé que chaque examen apporte des informations uniques sur le système respiratoire et permet d'identifier des sujets nécessitant des investigations plus poussées[79].…”

Asthma and rhinitis in cleaning workers: a systematic review of epidemiological studies

“…Direction and magnitude of bias was examined in three studies [24,30,31]. Study size was not explained in one cross-sectional study [29]. It was unclear if 3 studies were free of commercial funding [18,21,29].…”

Religious and Spiritual Biomarkers in Both Health and Disease

“…Earlier and current research is also limited by the failure to use simple non-invasive biomarker measurements that have been recently developed [14][15][16] and validated [17][18][19].…”