Effect of Extract Black Cumin (Nigella sativa) on the Vaginal Cytology of Ovariectomized White Mouse (Rattus Novergicus Strain Wistar)

Andriana, Kusuma; Lestari, Dwi Indah

doi:10.2991/hsic-17.2017.55

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…That to be known has a high estrogenic impact. It also displayed antifertility, antioxytocic action, act as emmenagogues and also possess numerous different properties [13]. In various mixes, the seeds of black cumin were utilized in fatness and for the prophylaxes of difficult breathing.…”

Section: Therapeutic Importance Of N Sativamentioning

confidence: 99%

Nigella Sativa (Kalonji), Its Essential Oils and Their Therapeutic Potential

Zhang¹,

Zou²,

Zhang

et al. 2021

BJSTR

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Nigella sativa originated from the Mediterranean region. It belongs to the family Ranunculaceae (butter-cup family). Used as spice and also generally used therapeutic plant all over the world. Customarily it is used to treat allergic disorders. Important medication in the Indian conventional methods of medication like Ayurveda (herbs) and Unani (roots of plants). Seeds are used as flavoring agent and preservatives. Black cumin seeds were extensively utilized for the cure of various ailments and conditions. In Islamic Literature, it is recognized as one of the ultimate forms of therapeutic medication. It has been widely used as aromatic, respiratory stimulant, diuretic, hypoglycemic, antitumor and an analgesic. N. sativa oil also have therapeutic properties and many active compounds. It is usually extracted by hydro-distillation method. Thymoquinone isolated from the black cumin is the principle main dynamic constituent of its volatile oil that involves in numerous biochemical and physical properties of this plant. The current review paper tries to describe the essential oils of N. sativa, their chemical composition as well as therapeutic activities.

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Section: Therapeutic Importance Of N Sativamentioning

confidence: 99%

Nigella Sativa (Kalonji), Its Essential Oils and Their Therapeutic Potential

Zhang¹,

Zou²,

Zhang

et al. 2021

BJSTR

View full text Add to dashboard Cite

show abstract

“…NS has a powerful constituent of antioxidants and protects against damage induced by the oxidative processes and the abilities to binding to protein targets. Thus, it may prevent neuronal cell death and improve cognitive function (8,(10)(11)(12) . NS, as a herbal medicine has been widely recognized for its potential biological activities, such as a diuretic, antihypertensive, antidiabetic, anticancer, immunomodulatory, antimicrobial, anthelmintic, analgesic, a spasmolytic, bronchodilator, anti-inflammatory, antitussive, gastroprotective, hepatoprotective, reduce LDL, renal protective and antioxidants (13)(14)(15)(16)(17)(18)(19)(20) .…”

Section: Introductionmentioning

confidence: 99%

In Silico Prediction of Potential Compounds of Nigella sativa as Aromatase Agonists and Ability to Cross the Blood-Brain Barrier for treatment of Alzheimer’s Disease

Andriana¹,

Nurdiana²,

Barlıanto³

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Background: Alzheimer's disease (AD), is a chronic neurodegenerative disease which condition is characterized by a decline in memory, thinking skills, and the ability to perform basic activities of daily living. Study showed that postmenopausal women with AD had a lower aromatase activity (p450 aromatase) in the brain compared to menopausal women without AD. To improve cognitive function in AD patients, Nigella sativa (NS) was found to have a protective effect on memory, and cognitive function. This study therefore, aimed to investigate in silico prediction of potential compounds of Nigella sativa as aromatase agonists and ability to cross the Blood-Brain Barrier (BBB) for treatment of Alzheimer's Disease. Methods: The data sets used in this study were collected from databases KnapSack Kanaya, PubChem, and PASS server Way2Drug. HitPick and Autodock Vina was performed. Additionally, the systematic analysis involved ADMET, LMMD, and SWISS ADME. Results and Discussions: In silico test results revealed the most promising constituents in 36 active NS compounds that may have potential to reduce the severity of the AD, owing to its anti-inflammatory, cytochrome p450 stimulants, free radical scavengers, antioxidants, and immunomodulators. The ability of NS to cross the BBB was proven by admetSAR LMMD with an analysis average value of 0.91 (from the highest value of 1). Further, NS can trigger cytochrome P450 aromatase activity via Quercetin 3-(6'' ''-feruloylglucosyl)-(1->2)-galactosyl-(1->2)-glucoside which has a better binding affinity value than its control (androstenedione). NS through oleic acid compounds may bind to peroxisome proliferator-activated receptor gamma (PPRAG), similar to Rosiglitazone which may affect transcription and activation regulation of PPARG. Conclusion: To be concluded, Nigella sativa could be used as a potential medicinal plant for the treatment of Alzheimer's disease.

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Effect of Extract Black Cumin (Nigella sativa) on the Vaginal Cytology of Ovariectomized White Mouse (Rattus Novergicus Strain Wistar)

Abstract: ABSTRACT

Cited by 2 publications

References 7 publications

Nigella Sativa (Kalonji), Its Essential Oils and Their Therapeutic Potential

Nigella Sativa (Kalonji), Its Essential Oils and Their Therapeutic Potential

In Silico Prediction of Potential Compounds of Nigella sativa as Aromatase Agonists and Ability to Cross the Blood-Brain Barrier for treatment of Alzheimer’s Disease

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