Effect of fasting hyperglycemia and insulin resistance on bone turnover markers in children aged 9–11 years

Biliński, Wojciech; Szternel, Lukasz; Siódmiak, Joanna; Krintus, Magdalena; Paradowski, Przemysław T.; Domagalski, Krzysztof; Sypniewska, Grażyna

doi:10.1016/j.jdiacomp.2021.108000

Cited by 7 publications

(8 citation statements)

References 33 publications

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“…Venous blood samples were taken in a fasting state in order to obtain serum, and whole blood was collected for glycated hemoglobin (HbA1c) assay. The following parameters: glucose, triglycerides (TG), HDL-cholesterol (HDL-C), C-reactive protein (CRP) and HbA1c, were measured immediately, as previously described [ 20 ]. Total 25-hydroxyvitamin D (25(OH)D), intact-P1NP, CTX-1 and insulin were assayed in previously deep-frozen serum samples, as reported earlier [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

“…The following parameters: glucose, triglycerides (TG), HDL-cholesterol (HDL-C), C-reactive protein (CRP) and HbA1c, were measured immediately, as previously described [ 20 ]. Total 25-hydroxyvitamin D (25(OH)D), intact-P1NP, CTX-1 and insulin were assayed in previously deep-frozen serum samples, as reported earlier [ 20 ]. Total 25(OH)D, i-P1NP and CTX-1 were analyzed on an IDS-iSYS automated platform (Immunodiagnostic Systems Holding PLC, Boldon, UK).…”

Section: Methodsmentioning

confidence: 99%

“…Total 25(OH)D, i-P1NP and CTX-1 were analyzed on an IDS-iSYS automated platform (Immunodiagnostic Systems Holding PLC, Boldon, UK). Insulin resistance was assessed on the basis of the calculated homeostasis model assessment (HOMA-IR) and bone turnover index (BTI) was calculated as previously described [ 20 ]. All laboratory tests were performed at the Department of Laboratory Medicine, Collegium Medicum, Nicolaus Copernicus University in Torun.…”

Section: Methodsmentioning

confidence: 99%

“…Fasting insulin ≥ 12 µU/mL was accepted as hyperinsulinemia and CRP concentration > 3 mg/L as increased. BTI was calculated based on the results of i-P1NP and CTX-1 concentrations as previously described [ 20 ]. Positive BTI indicated that bone formation prevails over bone resorption, while a negative BTI value reflected the predominance of bone resorption [ 11 ].…”

Section: Methodsmentioning

confidence: 99%

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Relationships between Bone Turnover Markers and Factors Associated with Metabolic Syndrome in Prepubertal Girls and Boys

Biliński¹,

Stefańska

Szternel

et al. 2022

Nutrients

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The associations between individual components of metabolic syndrome (MetS) and bone health in children are complex, and data on this topic are sparse and inconsistent. We assessed the relationship between bone turnover markers and markers of the processes underlying MetS (insulin resistance and inflammation) in a group of presumably healthy children aged 9–11 years: 89 (51 girls, 38 boys) presenting without any features of MetS and 26 (10 girls, 16 boys) with central obesity and two features of MetS. Concentrations of glucose, triglycerides (TG), HDL cholesterol (HDL-C), C-reactive protein (CRP), HbA1c, total 25-hydroxyvitamin D (25(OH)D), intact-P1NP (N-terminal propeptide of type I procollagen), CTX-1 (C-terminal telopeptide of type I collagen) were assayed and insulin resistance was assessed (HOMA-IR). BMI centile, waist circumference (WC) and blood pressure were measured. The presence of MetS in girls resulted in significantly lower concentrations of CTX-1 and a trend to lower CTX-1 in boys. The concentrations of bone formation marker i-P1NP were not affected. Among the features associated with MetS, HOMA-IR appeared as the best positive predictor of MetS in girls, whereas CRP was the best positive predictor in boys. A significant influence of HOMA-IR on the decrease in CTX-1 in girls was independent of BMI centile and WC, and the OR of having CTX-1 below the median was 2.8-fold higher/1SD increased in HOMA-IR (p = 0.003). A weak relationship between CTX-1 and CRP was demonstrated in girls (r = −0.233; p = 0.070). Although TG, as a MetS component, was the best significant predictor of MetS in both sexes, there were no correlations between bone markers and TG. We suggest that dyslipidemia is not associated with the levels of bone markers in prepubertal children whereas CRP is weakly related to bone resorption in girls. In prepubertal girls, insulin resistance exerts a dominant negative impact on bone resorption, independent of BMI centile and waist circumference.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Relationships between Bone Turnover Markers and Factors Associated with Metabolic Syndrome in Prepubertal Girls and Boys

Biliński¹,

Stefańska

Szternel

et al. 2022

Nutrients

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“…The bone turnover index (BTI) was calculated as previously described in detail [21,22]. The BTI value provides additional information on the bone turnover [21].…”

Section: Laboratory and Anthropometric Measurementsmentioning

confidence: 99%

Low Serum 25-hydroxyvitamin D Level Does Not Adversely Affect Bone Turnover in Prepubertal Children

Biliński¹,

Szternel

Siódmiak

et al. 2021

Nutrients

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Both vitamin D and insulin-like growth factor 1 (IGF-1) play essential roles in bone metabolism and may interact during prepubertal bone accrual. We investigated the association of low serum 25-hydroxyvitamin D (25(OH)D) (<20 ng/mL) with the circulating bone turnover markers, when compared to their interaction with IGF-1. Subjects and Methods: Serum 25(OH)D, IGF-I, P1NP (N-terminal propeptide of type I procollagen), and CTX-1 (C-terminal telopeptide of type I collagen) were measured, and the bone turnover index (BTI) was calculated in 128 healthy children, aged 9–11 years. Results: Mean 25(OH)D concentration was 21.9 ± 4.9 ng/mL, but in 30.5% of participants it was <20 ng/mL (<50 nmol/L). We observed a trend for higher P1NP (p < 0.05) and IGF-1 (p = 0.08), towards lower 25(OH)D in tertiles. Levels of P1NP in the lowest 25(OH)D tertile (<20 ng/mL) were the highest, while CTX and BTI remained unchanged. Additionally, 25(OH)D negatively correlated with IGF-1, while the correlation with P1NP was not significant. A strong positive correlation of IGF-1 with P1NP and BTI but weak with CTX was observed. Low 25(OH)D (<20 ng/mL) explained 15% of the IGF-1 variance and 6% of the P1NP variance. Conclusions: Low levels of 25(OH)D do not unfavorably alter bone turnover. It seems that serum 25(OH)D level may not be an adequate predictor of bone turnover in children.

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The relationship between obesity and bone mineral density in children and adolescents: analysis of the National Health and Nutrition Examination Survey

Lü

Zhang

et al. 2023

Arch Osteoporos

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Effect of fasting hyperglycemia and insulin resistance on bone turnover markers in children aged 9–11 years

Cited by 7 publications

References 33 publications

Relationships between Bone Turnover Markers and Factors Associated with Metabolic Syndrome in Prepubertal Girls and Boys

Relationships between Bone Turnover Markers and Factors Associated with Metabolic Syndrome in Prepubertal Girls and Boys

Low Serum 25-hydroxyvitamin D Level Does Not Adversely Affect Bone Turnover in Prepubertal Children

The relationship between obesity and bone mineral density in children and adolescents: analysis of the National Health and Nutrition Examination Survey

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