Effect of fasting on the rates of lactate turnover and oxidation in rats

Fréminet, A.; Leclerc, L; Gentil, Michèle; Poyart, Claire

doi:10.1016/0014-5793(75)80765-4

Cited by 14 publications

(12 citation statements)

References 15 publications

(7 reference statements)

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“…Data for body weight, respiratory parameters and rates of glucose and lactate turnover obtained in this series of experiments have been reported in earlier communications [1,2] aMean -+ SEM. bAlready published [2].…”

Section: Resultsmentioning

confidence: 89%

“…In a recent study, we have reported decreased lactate turnover and oxidation rates in fasted rats [ 1]. Concomitantly, the rate of total glucose recycling (Glucose~X--~Glucose: TGR), estimated as the difference between the true ([2-all] glucose) and the apparent ([U-14C] glucose) rates of glucose turnover, was lowered after 24, 48 and 72 h of fast [2].…”

Section: Introductionmentioning

confidence: 89%

“…to water until the experiments which were performed in the morning at 8:30 AM. The experimental procedure and set up has been previously described in full details [1,3,9]. After an equilibrating period of 30 min following anaesthesia and surgery which allows a normal blood acid-base and oxygenation status of the animals, a solution of [u-X4C]lactate or of [2-3H]-and [U-14C]glucose was infused at a constant rate during 120 rain.…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, the aim of the present report is to estimate the fractionnal participation of CC to TGR in fasted rats. To do so, previous data [1,2] were tested with a more sophisticated analytical method [3]. This study shows that during fasting CC is only slightly reduced and accounts entirely for TGR.…”

Section: Introductionmentioning

confidence: 99%

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Effect of fasting on the Cori cycle in rats

et al. 1976

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Section: Resultsmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 89%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of fasting on the Cori cycle in rats

et al. 1976

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“…In contrast with the controls, no reduction of lactate was observed in PCS after a 48-hour fast. This could suggest that a shorter fast stimulates utilization of lactate for gluconeogenesis in PCS rats [8],…”

Section: R Esultsmentioning

confidence: 99%

Composition of Free Fatty Acids and Adipose Tissue Triglycerides in Portacaval Shunted Rats

Merli

Sacchini

Iapichino³

et al. 1987

Eur Surg Res

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This study was designed to determine the individual fatty-acid pattern in plasma and in two adipose tissue sites of rats submitted to portacaval shunt (PCS) using the button technique. The animals were studied both in a fed state and after a 48-hour fast. Glucose, ketone bodies (KB), lactate and pyruvate levels were also measured. The results of the shunted animals were compared with pair-fed and freely fed control groups. In PCS rats, plasma free fatty-acid (FFA) levels were not significantly higher than in freely fed controls. β-Hydroxybutyrate was significantly lower in PCS rats compared with both control groups. A 48-hour fast caused an elevation of plasma FFA and KB in all groups, but in PCS rats this increase was less pronounced. Lactate levels did not decrease during fasting in PCS rats, as they did in the control groups. PCS did not modify plasma FFA or the adipose tissue composition, neither in fed nor in fasted rats. We conclude that the PCS rats operated upon by using the button technique show mild modifications in lipid metabolism, affecting the fatty-acid composition neither in plasma FFA nor in adipose tissue.

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Glucose metabolism studied isotopically in diabetic dogs: Effect of restoration of peripheral normoinsulinaemia by the artificial B cell

1983

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Normoglycaemia, peripheral normoinsulinaemia, and normoglucagonaemia were restored acutely in chronically diabetic dogs, using an extracorporal artificial B cell with peripheral venous insulin administration. Glucose metabolism was analysed by a non-steady-state tracer technique with double-labelled glucose (6-3H- and U-14C-glucose), and the incorporation of the 14C label into plasma lactate was determined. In the basal state, glucose turnover rates were not different from those in non-diabetic controls; but recirculation of the glucose-C label through the Cori cycle, and lactate labelling from glucose utilization were decreased. The glycaemic response to an intravenous infusion of non-labelled glucose was distinctly enhanced. This was based on a reduction in the rates of glucose disappearance. Its rates of appearance (total endogenous glucose production) were, however, suppressed to a normal extent by the exogenous glucose. Accordingly carbon recycling was nearly totally suppressed during the glucose infusion as in the controls. It is concluded that metabolic recompensation in these fasting, resting diabetic dogs remained incomplete because the interval of normoinsulinaemia, which obviously applied only to the peripheral circulation, was not long enough.

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Effect of fasting on the rates of lactate turnover and oxidation in rats

Cited by 14 publications

References 15 publications

Effect of fasting on the Cori cycle in rats

Effect of fasting on the Cori cycle in rats

Composition of Free Fatty Acids and Adipose Tissue Triglycerides in Portacaval Shunted Rats

Glucose metabolism studied isotopically in diabetic dogs: Effect of restoration of peripheral normoinsulinaemia by the artificial B cell

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