Effect of Feeding Maize/Legume Mixtures on Biochemical Indices in Rats

Obatolu, Veronica A.; Ketiku, A. O.; Adebowale, E.A.

doi:10.1159/000070041

Cited by 12 publications

(10 citation statements)

References 14 publications

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“…Total protein levels in rats fed high-fructose diet or quinoa diet were within the normal range for total protein [29]. Albumin level in all rats was similar because diets which were used in our study were protein sufficient.…”

Section: Discussionmentioning

confidence: 73%

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Effect of Quinoa Seeds (Chenopodium quinoa) in Diet on some Biochemical Parameters and Essential Elements in Blood of High Fructose-Fed Rats

Paśko

Zagrodzki

Bartoń

et al. 2010

Plant Foods Hum Nutr

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The effect of Chenopodium quinoa seeds on lipid profile, glucose level, protein metabolism and selected essential elements (Na, K, Ca, Mg) level was determined in high—fructose fed male Wistar rats. Fructose decreased significantly LDL [42%, p < 0.01] and activity of alkaline phosphatase [20%, p < 0.05], and increased triglycerides level [86%, p < 0.01]. The analysis of blood of rats fed quinoa indicated, that these seeds effectively reduced serum total cholesterol [26%, p < 0.05], LDL [57%, p < 0.008] and triglycerides [11%, p < 0.05] when compared to the control group. Quinoa seeds also significantly reduced the level of glucose [10%, p < 0.01] and plasma total protein level [16%, p < 0.001]. Fructose significantly decreased HDL [15%, p < 0.05] level in control group but when the quinoa seeds were added into the diet the decrease of HDL level was inhibited. Quinoa seeds did not prevent any adverse effect of increasing triglyceride level caused by fructose. It was shown in this study that quinoa seeds can reduce most of the adverse effects exerted by fructose on lipid profile and glucose level.

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Section: Discussionmentioning

confidence: 73%

“…Protein malnutrition is often associated with increased activity of alkaline phosphatase [29]. Obatolu et al [29] observed that malted maize and soybean caused significant increase in activity of alkaline phosphatase in comparison with non protein diet. This enzyme in non-specific and the interpretation of the results therefore is ambiguous.…”

Section: Discussionmentioning

confidence: 99%

Effect of Quinoa Seeds (Chenopodium quinoa) in Diet on some Biochemical Parameters and Essential Elements in Blood of High Fructose-Fed Rats

Paśko

Zagrodzki

Bartoń

et al. 2010

Plant Foods Hum Nutr

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“…Low protein diet involves a reduction in the rate of protein synthesis in most body tissues (Wykes et al 1996). The increase in serum alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in animals fed on a protein deficient diet, suggests hepatocellular dysfunctions (Tandon et al 1998;Obatolu et al 2003). The protein calorie malnutrition affects synthesis of the mRNA suggesting that a defect occurs at a pre-transcriptional level that results in reduced concentrations of mRNA (Adames et al 1996).…”

Section: Introductionmentioning

confidence: 99%

Time dependent study to evaluate the efficacy of zinc on hepatic marker enzymes and elemental profile in serum and liver of protein deficient rats

2005

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This study was designed to determine the time dependent protective effects of zinc sulfate on the serum and liver marker enzymes along with elemental profile in protein deficient Sprague Dawley (S.D.) female rats. Zinc sulfate in the dose of 227 mg/l in drinking water was administered to normal control as well as protein deficient rats for a total duration of 8 weeks. The effects of different treatments were studied on enzymes like alkaline phosphatase (ALP), aspartate aminotransferases (AST) and alanine aminotransferases (ALT) in rat serum at different time intervals of 1, 2, 4 and 8 weeks and in the rat liver at the end of study. The status of different essential elements in liver was also studied. The serum ALP activity got significantly depressed when estimated at the intervals of 4 and 8 weeks. Activity of serum ALT was significantly increased after 4 weeks interval in protein deficient rats and the increasing trend continued upto 8 weeks of protein deficiency. On the other hand, activity of AST showed a significant increase just after 2 weeks and activity continued to be increased up to 8 weeks. Moreover activities of all the hepato marker enzymes showed a significant increase in liver of protein deficient rats. Interestingly, supplementation of Zn to protein deficient rats helped in regulating the altered activities of ALP, AST and ALT both in serum and liver. However, zinc treatment alone to normal rats did not indicate any significant change in the activities of all the enzymes in liver as well serum except at the interval of 2 weeks where a marginal increase in the activity of AST was seen. It has also been observed that concentrations of zinc, copper, iron and selenium were found to be decreased significantly in protein deficient animals. However, the levels of these elements came back to within normal limits when zinc was administered to protein deficient rats.

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“…The supplementation of the two diets with S. abyssinica significantly reduced the activity of transaminases, indicating that S. abyssinica leaves powder restored the function of liver during protein-energy malnutrition treatment. Indeed, the increase in serum alanine aminotransferase and alkaline phosphatase in animals fed with protein deficient diet suggests hepatocellular dysfunctions (Obatolu et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Effect of Stephania abyssinica Leaves Powder Supplementation on some Biochemical Parameters and Immune-Nutritional Status of Malnourish early-Weaned Rats

Feudjio¹,

Simplice²,

Odette³

et al. 2020

J.Food.Stab

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Child malnutrition is a severe public health problem in Africa as a whole and Cameroon in particular. The objective of this study was to assess the effectiveness of Stephania abyssinica leaf powder as a nutritional supplement to treat protein-energy malnutrition in immature rats. The proximate composition of S. abyssinica leaves was assayed using standard methods. The 21 days old weaned rats were fed with low protein diet (2.5%) during 28 consecutive days. They were further fed with either normal diet (20% protein) or 2.5% protein diet supplemented each with S. abyssinica leaves powder at different doses (110 mg/kg, 220 mg/kg and 440 mg/kg) for 28 days. The establishment of protein-energy malnutrition and the recovery of rats following treatment were evaluated by determining, hematological parameter and transaminases activity. The proximate composition of S. abyssinica leaves showed that they are made up of 95.30% dry matter. Dry matter analysis revealed that it contains 27.54% crude proteins, 4.41% lipids, 54.12% carbohydrates and 9.23% ash content. S. abyssinica leaves as food supplement significantly improved the animal's health and immune system. Practical application S. abyssinica could be useful as food supplement to fight and prevent infant malnutrition as the powder displayed no toxicity on liver.

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Effect of Feeding Maize/Legume Mixtures on Biochemical Indices in Rats

Cited by 12 publications

References 14 publications

Effect of Quinoa Seeds (Chenopodium quinoa) in Diet on some Biochemical Parameters and Essential Elements in Blood of High Fructose-Fed Rats

Effect of Quinoa Seeds (Chenopodium quinoa) in Diet on some Biochemical Parameters and Essential Elements in Blood of High Fructose-Fed Rats

Time dependent study to evaluate the efficacy of zinc on hepatic marker enzymes and elemental profile in serum and liver of protein deficient rats

Effect of Stephania abyssinica Leaves Powder Supplementation on some Biochemical Parameters and Immune-Nutritional Status of Malnourish early-Weaned Rats

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