Effect of Feeding Methoxychlor–Treated Alfalfa Hay to Dairy Cows

Biddulph, Clyde; Bateman, G. Q.; Harris, Jonathan; Mangelson, Farrin L.; Lieberman, F. V.; Binns, Wayne; Greenwood, D. A.

doi:10.3168/jds.s0022-0302(52)93725-9

Cited by 5 publications

(1 citation statement)

References 5 publications

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“…Incidentally, the residues in the hay presumably resulted from translocation, because heptachlor was applied to the soil very early in the season and not to the maturing crop. Methoxychlor appears in the milk of cows following large doses (3 1, 158); but, according to Biddulph et al (169), the compound cannot be detected in the milk, blood, fat, kidney, liver, or muscle, under practical conditions of forage treatment with methoxychlor. Direct treatment of cows with methoxychlor leads to an increase of the com pound in the milk, but an undetermined proportion of it may reach the milk by extraneous contamination rather than secretion (170).…”

Section: Excretion and Storage Lossmentioning

confidence: 96%

Review of the Metabolism of Chlorinated Hydrocarbon Insecticides Especially in Mammals

Wj¹

1965

Annu. Rev. Pharmacol.

119

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This review discusses the absorption, storage, biotransformation, and excretion of chlorinated hydrocarbon insecticides; thus, it emphasizes those aspects of physiology that can be studied by the methods of analytical or ganic chemistry. The broader aspects of toxicity, as they relate to the me tabolism of these materials, were discussed by Winteringham & Barnes (1).This review emphasizes mammalian metabolism of the compounds, but con tains some information on their metaboli sm by other organisms, a subject that has already been reviewed by Perry (2). In relation to mammals, great est interest centers in numerous repeated doses that produce no obvious in jury and that are so small that they might be encountered under practical conditions in the use of insecticides. For this reason, DDT and related re sidual insecticides are emphasized, but some information is given on the chlorinated hydrocarbon fumigants.

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Section: Excretion and Storage Lossmentioning

confidence: 96%

Review of the Metabolism of Chlorinated Hydrocarbon Insecticides Especially in Mammals

Wj¹

1965

Annu. Rev. Pharmacol.

119

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Methoxychlor [MAK Value Documentation in German language, 1972]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 1. Lieferung, Ausgabe 1972 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Erfahrungen beim Menschen Tierexperimentelle Befunde Akute Toxizität bei Zufuhr per os Perkutane Toxizität Chronische Toxizität Begründung des MAK‐Wertes

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The toxicity of pesticides for livestock

Radeleff

1962

J Americ Oil Chem Soc

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Conclusion In this discussion I have covered the relationship of toxicity to hazard, and I have argued that normally expected residues of pesticides on forage are practically never a hazard to livestock, but that some of the pesticides are stored in the tissues of livestock and excreted in their milk, creating a potential hazard to people. This hazard can be avoided by carefully following label instructions as to dosage and proper intervals which must occur between treatment and harvest of slaughter. I have indicated that chemical analyses are of virtually no value for diagnostic purposes. I have pointed out that all the toxicological information developed for a given compound can be utilized only if the manufacturer, formulator, and consumer contribute equally to safe, intelligent usage. The manufacturers and formulators must prepare the compounds in stable, readily usable form, and devise labels for the final product, which will clearly define the intended uses and limitations of the product. The consumer must read the label and adhere strictly to the suggestions found there. I believe that the rational use of pesticides in agriculture is essential if we are to maintain maximum productivity in the face of constantly shrinking farm and ranch land and an exploding population. I believe that these materials can be, and are being, used with complete safety to man and animals when label instructions are followed.

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Effect of Feeding Methoxychlor–Treated Alfalfa Hay to Dairy Cows

Cited by 5 publications

References 5 publications

Review of the Metabolism of Chlorinated Hydrocarbon Insecticides Especially in Mammals

Review of the Metabolism of Chlorinated Hydrocarbon Insecticides Especially in Mammals

Methoxychlor [MAK Value Documentation in German language, 1972]

The toxicity of pesticides for livestock

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