Effect of Feeding Plant Polyphenolics on Fatty Acid Composition, Vitamin E Level and Degree of Lipid Peroxidation in Rat Organs.

Ando, Kiyohiro; Nagata, Kunihide; Yoshida, Rie; Kikugawa, Kiyomi; Suzuki, Masao

doi:10.5650/jos.50.13

Cited by 1 publication

(2 citation statements)

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“…The degree of lipid peroxidaion of lung of mice as assessed by levels of TBARS was enhanced by supplementation of DMHF or HHQ. A similar increase in the levels of TBARS of lung has been observed when plant polyphenolics are supplied to rats (31). In contrast, levels of TBARS of heart were slightly decreased by supplementtion of DMHF, and those of kidney and liver were significantly decreased by supplementation of HHQ.…”

Section: Discussionsupporting

confidence: 72%

“…Adverse activities of fragrant furanones including DMHF have been demonstrated in other in vitro studies: the activity providing oxidative conditions and the activity providing reducing conditions. The reductones generate reactive oxygen species to break DNA single strands in vitro in the presence of atmospheric oxygen (2-7), and they prevent Fe(III)-induced lipid peroxidation of red blood cell membranes and low-density lipoprotein in vitro (31). It is likely that which activity prevails depends on the target components and also on the environmental conditions.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Food Reductones, 2,5-Dimethyl-4-hydroxy-3(2H)-furanone (DMHF) and Hydroxyhydroquinone (HHQ), on Lipid Peroxidation and Type IV and I Allergy Responses of Mouse

Hiramoto

Kujirai

et al. 2001

J. Agric. Food Chem.

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The effect of long-term supplementation of food reductones, 2,5-dimethyl-4-hydroxy-3(2H)-furanone (DMHF) (2%, w/w), detected in many foodstuffs including soy sauce, and hydroxyhydroquinone (1,2,4-benzenetriol) (HHQ) (1.2%, w/w), detected in coffee, on mouse lipid peroxidation and type IV and I allergy responses was investigated. The effect of supplementation of these reductones combined with NO(2) inhalation (5-6 ppm) was also investigated. Levels of thiobarbituric acid-reactive substances in lung were remarkably increased, and those in kidney and liver were slightly decreased by supplementation of DMHF or HHQ. The degree of 2,4-dinitrochlorobenzene (DNCB)-sensitized lymph node cell proliferation as assessed by lymph node assay was remarkably enhanced by supplementation of DMHF or HHQ. Both the DNCB-sensitized and the trimellitic anhydride-sensitized increases in IgE levels of mice were enhanced to greater extent by supplementation of DMHF or HHQ. In no cases were additive effects of NO(2) inhalation observable. Allergen-sensitized type IV and I allergy responses of mice may be enhanced by supplementation of food reductones, DMHF or HHQ.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%