Effect of feeding whey peptide fractions on the immune response in healthy and Escherichia coli infected mice

Proliferative effects of synthetic peptides from β-lactoglobulin and α-lactalbumin on murine splenocytes

“…However, those peptides have to be absorbed and brought to the gastrointestinal immune system in order to show activity on immune cells. Although this aspect was not evaluated in the present study, we have recently shown that oral administration of whey peptide fractions in mice influenced immune parameters, such as serum IgA secretion and cytokine production (Saint-Sauveur et al, 2009). Our results also support the concept of multifunctional properties of food-derived peptides.…”

“…Both in vitro and in vivo studies have demonstrated that certain whey-protein-based ingredients (WPC, WPI) and individual whey proteins such as b-lactoglobulin (b-Lg), a-lactalbumin (a-La) and lactoferrin (Lf) can influence the immune response (Gauthier, Pouliot, & Saint-Sauveur, 2006;Korhonen & Pihlanto, 2006;Rutherfurd-Markwick & Gill, 2005; Saint-Sauveur, Gauthier, Boutin, & Montoni, 2008;Saint-Sauveur, Gauthier, Boutin, Montoni, & Fliss, 2009;Zimecki & Kruzel, 2007). Several studies have also shown that whey protein enzymatic hydrolysates possess immunomodulating effects, suggesting the enzymatic release of bioactive peptides from these proteins (Biziulevi cius, Kisluknina, Kazlauskaitè, & Zukaitè, 2006;Biziulevi cius & Kazlauskaitè, 2006Gauthier et al, 2006;Saint-Sauveur et al, 2008.…”

Immunomodulatory activities of whey β-lactoglobulin tryptic-digested fractions

“…Although induction of TGFb production by whey hydrolysated fractions has been reported in mice (Saint-Sauveur, Gauthier, Boutin, Montoni, & Fliss, 2009), this is the first study showing a significant effect on human cells, and not only on TGFb, but also on the Treg population.…”

Efectos fisiológicos de los péptidos bioactivos derivados de las proteínas del lactosuero en la salud: Una revisión

“…Además, la lactoferricina ha mostrado capacidad para bloquear la actividad de la interleucina-6 (IL-6), citoquina relacionada con los procesos inflamatorios de la artritis reumatoide 33 . Saint-Sauveur et al (2009) reportaron el aumento de la cantidad de IgA en ratones que fueron alimentados por 7 días con fracciones peptídicas del lactosuero induciendo la producción de interleucina-2 (IL-2) e interferón gama (IFNγ) que generan la activación de monocitos y neutrófilos 34 . Asimismo, se ha reportado que los PBDL mejoran la proliferación de linfocitos 7 , inhiben la liberación de la citoquina pro-inflamatoria IL-8 35 y la cantidad de especies reactivas de oxígeno en ratones 29 .…”