Effect of fenugreek consumption with metformin treatment in improving plaque index in diabetic patients

Sundaram, Gopalakrishnan; Theagarajan, Ramakrishnan; Kanimozhi, Gopalakrishnan; Babu, Gnanasagar Ramesh; Murthy, Gomathi Dhakshina

doi:10.4103/jnsbm.jnsbm_96_19

Cited by 6 publications

(13 citation statements)

References 26 publications

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“…The articles were published between 2015 and 2021 and most of them were conducted in Asian countries (India [45][46][47][48][49], Iran [50,51], Thailand [52], and Egypt [53]), except one, which was performed in Romania [54]. In all included studies, a periodontal clinical examination was conducted to confirm the diagnosis of periodontitis, while the diagnosis of T2D was confirmed by laboratorial tests for HbA1c level.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…In all included studies, a periodontal clinical examination was conducted to confirm the diagnosis of periodontitis, while the diagnosis of T2D was confirmed by laboratorial tests for HbA1c level. Regarding anti-glycemic therapy, only the studies that evaluated omega-3, ALA and fenugreek specified the concomitant use of metformin 500 mg/day by oral route [46,48,49].…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…The intervention in the test groups (TGs) was NSPT plus antioxidants and in the control groups (CGs) it was NSPT alone [47][48][49]51] or associated to placebo [45,46,50,[52][53][54].…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Considering all included studies, 20 patients were treated with alpha lipoic acid (ALA) [49], 40 with fenugreek [48], 20 with lycopene [47], 24 with omega-3 fatty acid [46,51], 9 with cranberry juice [51], 10 with cranberry juice enriched with omega-3 [51], 15 with vitamin C [52], 24 with propolis [53], 21 with ginger [50], 24 with grape seed extracts [45] and 27 with melatonin [54]. In control groups, 92 patients underwent NSPT alone [47][48][49]51], while 128 received placebo together with NSPT [45,46,50,[52][53][54]. Excepting one study [51], all the others evaluated only one antioxidant each.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Efficacy of Antioxidant Supplementation to Non-Surgical Periodontal Therapy on Metabolic Control in Type 2 Diabetes Patients: A Network Meta-Analysis

et al. 2022

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This network meta-analysis (NMA) investigated the effectiveness of antioxidants as adjuncts to non-surgical periodontal therapy (NSPT) in the glycated hemoglobin (HbA1c) control of type 2 diabetes (T2D) patients with periodontitis. PubMed, Cochrane, LILACS, Web of Science, Scopus, Embase, LIVIVO, and grey literature were searched. Risk of bias was assessed with the RoB v2.0 tool. A frequentist NMA assessed HbA1c improvement, through standardized mean difference under a random-effects model. Certainty of evidence was addressed through the GRADE (Grading of Recommendations, Assessment, Development and Evaluations) partially contextualized framework. Ten randomized controlled clinical trials were included, with 234 patients receiving alpha lipoic acid (ALA), cranberry juice, cranberry juice enriched with omega-3, fenugreek, ginger, grape seed, lycopene, melatonin, omega-3, propolis or vitamin C supplementation to NSPT, and 220 patients receiving NSPT alone or with placebo. Nine studies were meta-analyzed. HbA1c improved when NSPT was combined with propolis, ALA and melatonin supplementation (moderate-to-low certainty), compared to NSPT alone or with placebo. Risk of bias issues were found in eight studies. In conclusion, the use of propolis supplementation to NSPT probably results in HbA1c improvement in T2D patients with periodontitis (large effect with moderate certainty), while ALA and melatonin supplementation may contribute to reduce the HbA1c in T2D patients with periodontitis (large effects with low certainty).

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Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…The intervention in the test groups (TGs) was NSPT plus antioxidants and in the control groups (CGs) it was NSPT alone [47][48][49]51] or associated to placebo [45,46,50,[52][53][54].…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy of Antioxidant Supplementation to Non-Surgical Periodontal Therapy on Metabolic Control in Type 2 Diabetes Patients: A Network Meta-Analysis

et al. 2022

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“…Currently, there is a growing interest regarding the potential beneficial effects of alternative therapies to improve the metabolic parameters in T2D (Hadi et al, 2020; Heshmati et al, 2020; Nauck et al, 2021). In this context, herbal medicine has been introduced as an auxiliary method along with lifestyle interventions and drug therapy (Heshmati et al, 2021; Kumar et al, 2021; Moholkar Aparark et al, 2021; Sundaram et al, 2020; Tajaddini et al, 2021). In recent years, many studies have reported the beneficial effects of herbal compounds such as green tea (Xu et al, 2020), nettle (Ziaei et al, 2020), barberry (Safari et al, 2020), and saffron (Sohaei et al, 2020) on the control of glycemic markers.…”

Section: Introductionmentioning

confidence: 99%

Effect of sesame (Sesamum indicum L.) consumption on glycemic control in patients with type 2 diabetes: A systematic review and meta‐analysis of randomized controlled trials

Ramírez‐Coronel

Alhilali

Ahmed

et al. 2023

Phytotherapy Research

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Conflicting evidence exists on the effect of sesame consumption on glucose metabolism in patients with type 2 diabetes (T2D). Therefore, this meta‐analysis focuses on the relationship between sesame (Sesamum indicum L.) intervention and glycemic control in patients with T2D. Published literature was retrieved and screened from PubMed, Scopus, ISI Web of Science, and the Cochrane Library up to December 2022. Outcome measures included fasting blood sugar (FBS) concentrations, fasting insulin levels, and hemoglobin A1c (HbA1c) percentage. Pooled effect sizes were reported as weighted mean differences (WMDs) and 95% confidence intervals (CIs). Eight clinical trials (395 participants) were eligible for meta‐analyses. Overall, sesame consumption significantly reduced serum FBS (WMD: −28.61 mg/dL, 95% CI: −36.07 to −21.16, p˂0.001; I2 = 98.3%) and HbA1c percentage (WMD: −0.99%, 95% CI: −1.22 to −0.76, p ≤ 0.001; I2 = 65.1%) in patients with T2D. However, sesame consumption did not significantly influence fasting insulin levels (Hedges's: 2.29, 95% CI: −0.06 to 4.63, p = 0.06; I2 = 98.1%). In summary, the current meta‐analysis showed a promising effect of sesame consumption on glycemic control through reducing FBS and HbA1c, yet additional prospective studies are recommended, using higher doses and longer intervention period, to confirm the impact of sesame consumption on insulin levels in T2D patients.

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The multifaceted potential of fenugreek seeds: From health benefits to food and nanotechnology applications

Faisal,

Irfan,

Akram

et al. 2024

Food Science & Nutrition

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The present lifestyle, dietary patterns, psychological pressure, environmental factors, and the widespread exploitation of processed substances in food production and farming have collectively contributed to a substantial expediting in the development of various health problems. Globally, researchers have been seeking natural pharmaceutical substances with the potential to be employed in treating lifestyle‐related diseases or delaying their onset. Fenugreek seeds have gained significant attention in various fields, including health, nutrition, and cutting‐edge nanotechnology applications, due to their versatile qualities. The current investigation offers a comprehensive discussion of the nutritional composition and therapeutic potential of fenugreek seeds, with an emphasis on their plentiful reservoir of bioactive compounds. This seed demonstrates promising medicinal potential in addressing a wide range of health issues. Significantly, these findings indicate noteworthy properties, such as antidiabetic, antioxidant, anti‐obesity, hypocholesterolemic, anticancer, and cardioprotective effects. Moreover, the components of fenugreek seeds are important in the development of a multitude of foods, which is the reason why they are used extensively in the area of food research. In addition to their nutritional value, their exploration of nanotechnology reveals a promising domain, utilizing the distinctive characteristics of seeds for many purposes, such as nanoparticle synthesis and oil for edible films and nanoemulsions. This review article focuses on a comprehensive analysis of fenugreek seeds, examining their wide‐ranging applications in the fields of health, nutrition, food, and nanotechnology.

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Effect of fenugreek consumption with metformin treatment in improving plaque index in diabetic patients

Cited by 6 publications

References 26 publications

Efficacy of Antioxidant Supplementation to Non-Surgical Periodontal Therapy on Metabolic Control in Type 2 Diabetes Patients: A Network Meta-Analysis

Efficacy of Antioxidant Supplementation to Non-Surgical Periodontal Therapy on Metabolic Control in Type 2 Diabetes Patients: A Network Meta-Analysis

Effect of sesame (Sesamum indicum L.) consumption on glycemic control in patients with type 2 diabetes: A systematic review and meta‐analysis of randomized controlled trials

The multifaceted potential of fenugreek seeds: From health benefits to food and nanotechnology applications

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