Effect of Fermented Camel Milk on Obesity Measures and Blood Pressure of Adolescents With Metabolic Syndrome

Fallah, Zahra; Feizi, Awat; Hashemipour, Mahin; Namazi, Nasim; Azarbayejani, Leila; Kelishadi, Roya

doi:10.32598/jpr.7.3.181

Cited by 10 publications

(6 citation statements)

References 28 publications

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“…Li et al (2004) reported that the addition of trypsin was essential to release an ACE-inhibitory peptide from a protein chain, and it enhanced ACE-inhibitory activity in rats. The potential factor for camel milk blood pressure lowering effect was attributed to the balance between the formation of ACE-inhibitory peptides and their subsequent degradation (Fallah et al , 2019). The rate of ACE expression vs its degredation in HM-treated rats is very important For this, both SDS-PAGE/western blot and western blot analysis or reverse transcription polymerase chain reaction should be performed to answer this critical question (Bartlett et al , 2012).…”

Section: Resultsmentioning

confidence: 99%

Effects of camel milk hydrolysate on blood pressure and biochemical parameters in fructose-induced hypertensive rats

Alshuniaber

Alhaj

Abdallah

et al. 2021

NFS

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Purpose This study aims to investigate the antihypertensive effect of camel milk hydrolysate in rats with fructose-induced hypertension. Design/methodology/approach The antihypertensive effect of fermented camel milk was determined using 6 groups comprising 36 Wistar male rats. Blood pressure of rats was altered via exposure to a 10% fructose (w/v) diet in drinking water for 3 weeks before conducting 21 days of treatment. The authors conducted the experiment for short and long term using different doses of 800 and 1,200 mg/kg body weight. Serum was used to assay total cholesterol (TC), triglyceride (TG), glucose and insulin levels using standard biochemical kits. Findings The group that received 1,200 mg hydrolysate camel milk (HM) has significantly (p = 0.003) reduced systolic and diastolic blood pressure after a short exposure time (4–8 h). These effects were significantly (p = 0.005) comparable to the nifedipine (NIF) drug group. Similar long-term (21 days) effects on blood pressure were observed in 1,200 mg HM and NIF groups. Angiotensin-converting enzyme (ACE) activity and levels were also reduced in a correlation with blood pressure reduction only in HM1200 and HM800 treated groups. The authors observed no significant effect on blood pressure in groups receiving the 800 mg HM or 1,200 mg unhydrolyzed camel milk (UM). Rats receiving the 10% fructose diet showed significant differences from control rats regarding their blood biochemistry, including TG, TC, blood glucose and insulin levels. Rats in groups NIF, HM1200 and HM800 showed a significant (p < 0.05) reduction in serum glucose, insulin, TG and TC levels toward the baseline level. Research limitations/implications Further mechanistic investigation on the HM antihypertensive activity is highly recommended before suggesting HM as a product to reduce blood pressure. While drug–food interaction between HM and antihypertensive drugs, especially ACE inhibitors, is probable, UM seems not to affect blood pressure or ACE activity and therefore is expected to have no or minimal effects on the activity of other antihypertensive drugs. Investigation of ACE expression from various organs including lungs and leukocytes is highly recommended in future works using sodium dodecyl-sulfate polyacrylamide gel electrophoresis and western blot analysis or reverse transcription polymerase chain reaction. Originality/value No previous studies have measured the antihypertensive activity of milk hydrolysate mediated by the reduction of ACE activity and levels in plasma. Mechanisms involved in attenuating the levels of ACE warrant further investigation.

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Section: Resultsmentioning

confidence: 99%

Effects of camel milk hydrolysate on blood pressure and biochemical parameters in fructose-induced hypertensive rats

Alshuniaber

Alhaj

Abdallah

et al. 2021

NFS

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“…An increase in IL6 levels and a decrease in TNF were also observed with fermented products or shubat [16]. Among other studies on fermented camel milk [37,38] some presented that there was no effect on TNF with fermented milk in diabetic cases [36]. Camel milk was able to lower blood sugar and postprandial blood sugar, HbA1c, and HOMA -IR in type 2 diabetes patients; But had no effect on glucose tolerance; Therefore, peptide C levels were higher with the consumption of fermented camel milk.…”

Section: Before Using Camel Milkmentioning

confidence: 87%

“…250 mL diluted kefi r and yogurt, or camel dough was used daily for eight weeks in diabetic patients with the same conditions [36]. The results showed that IL6 and TNF decreased and glucose metabolizing hormone GIP and GLP1 increased signifi cantly.…”

Section: Before Using Camel Milkmentioning

confidence: 98%

“…Camel milk was able to lower blood sugar and postprandial blood sugar, HbA1c, and HOMA -IR in type 2 diabetes patients; But had no effect on glucose tolerance; Therefore, peptide C levels were higher with the consumption of fermented camel milk. Proper function of the pancreatic islets and stimulation of endogenous insulin secretion was observed by 250 to 500 mL shut [36].…”

Section: Before Using Camel Milkmentioning

confidence: 99%

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Camel milk; A potent superfood for diabetes complications

Taherah,

Rajesh

2024

Food Sci Nutr The

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Currently, camel milk has been considered around the world due to awareness of its unique health benefits. Camel milk is considered a superfood with special nutrients and therapeutic values. In diabetes or hyperglycemia, the cells may not respond properly to insulin or defects in insulin secretion by the pancreas, therefore glucose level of blood is excessive. Chronic hyperglycemia is associated with dysfunction in the eyes, heart, nerves, kidneys, liver, and blood vessels. Insulin and oral hypoglycemic drugs are used for diabetes, but a high percentage of patients cannot use allopathic drugs and rely on natural alternative healings. Furthermore, coagulation of oral insulin in an acidic environment neutralizes and decreases the efficacy of insulin. Camel milk contains insulin-like proteins and may be an effective alternative for insulin to treat type 1 and 2 and gestational diabetes. Camel milk may prepare about 60% of the insulin in diabetic patients and reduce blood sugar and required insulin doses of about 30% - 35% in type 1 diabetes patients. This milk is believed to be a suitable hypoglycemic agent in improving long-term glycemic control in experimental animals and diabetic patients, as well as improving diabetes risk factors such as liver and kidney failures and cardiovascular challenges. It appears that more scientific studies are needed to confirm the efficacy of processed camel milk on diabetes. This review represents scientific studies on how camel milk as a superfood can be effective in diabetes.

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“…Methods are discussed elsewhere which present other findings of the study. [ 20 21 ] Here, we explain methods in more detail.…”

Section: Methodsmentioning

confidence: 99%

Effect of fermented camel milk on glucose metabolism, insulin resistance, and inflammatory biomarkers of adolescents with metabolic syndrome: A double-blind, randomized, crossover trial

et al. 2018

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Background:This study, for the first time, aimed to assess the effects of fermented camel milk (FCM) on glycemic and inflammatory parameters related to metabolic syndrome (MetS), an aggregation of cardiometabolic risk factors, in adolescents.Materials and Methods:In a double-blind, randomized crossover trial, overweight/obese adolescents (fulfilling MetS criteria, aged 11–18 years) were randomly assigned to receive FCM 250 cc per day for an 8-week period, a 4-week washout, and then diluted cow's yogurt (DCY) 250 cc/day for another 8-week period, or the reverse sequence. Fasting blood sugar (FBS), fasting insulin, insulin resistance by three equations, incretin hormone glucose-dependent insulinotropic peptide (GIP), and glucagon-like peptide-1 (GLP1) as well as inflammatory markers such as interleukin 6 (IL6) and tumor necrosis factor-alpha (TNF-α) were measured before and after each of the four periods. A 3-day food record and physical activity questionnaire were completed before each period. Statistical analyses were done using Minitab and SPSS software considering the significance level of 0.05.Results:Twenty-four participants with a mean (standard deviation) age of 13.77 (1.87) years (range: 10.45–16.25 years) (58% girls) completed the study. It resulted in nonsignificant mean reduction in IL6 (−18.28 pg/mL [95% confidence interval [CI]: −47.48; 10.90]; P = 0.20) and nonsignificant increase in glucose metabolizing hormones such as GIP (683.10 pg/mL [95% CI: −457.84; 1824.0]; P = 0.22) and GLP1 (6.98 pg/mL [95% CI: −66.61; 80.57]; P = 0.84) by FCM consumption in comparison to DCY. Nonsignificant decrease was observed in TNF-α in the first periods of the study. The changes of FBS, fasting insulin, and insulin resistance indices were not statistically significant as well.Conclusion:According to preliminary positive influences of FCM on inflammatory markers, and findings related to glucose metabolism, we suggest conducting further studies on its clinical impacts.

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Effect of Fermented Camel Milk on Obesity Measures and Blood Pressure of Adolescents With Metabolic Syndrome

Cited by 10 publications

References 28 publications

Effects of camel milk hydrolysate on blood pressure and biochemical parameters in fructose-induced hypertensive rats

Effects of camel milk hydrolysate on blood pressure and biochemical parameters in fructose-induced hypertensive rats

Camel milk; A potent superfood for diabetes complications

Effect of fermented camel milk on glucose metabolism, insulin resistance, and inflammatory biomarkers of adolescents with metabolic syndrome: A double-blind, randomized, crossover trial

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