Effect of fexofenadine hydrochloride on cedar pollinosis

Miyabe, Satoshi; Koizuka, Izumi; Ochi, Kentaro; Tanaka, Kenjiro; Kuroda, Hisashi; Takatsu, Mitsuharu; Kinoshita, Hirotsugu; Sugiyama, Yutaka

doi:10.1016/s0385-8146(02)00138-4

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…Other studies by SinghFranco showed the high efficacy of levocetirizine for the treatment of allergic rhinitis and chronic urticaria in adults and children, and its good tolerability [15]. And Miyabe's studies confirmed that fexofenadine may be successfully used to suppress the symptoms of allergic rhinitis [16]. The majority of Japanese research also emphasizes the high efficacy previously shown for antihistamine therapy [17].…”

Section: Discussionmentioning

confidence: 96%

Second generation antihistamines: assessment of the efficacy of treatment and tolerance of some preparations of this group (preliminary studies)

Czarny-Działak¹,

Głuszek-Osuch²

2016

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Introduction: Second generation antihistamines are key medicines in the treatment of allergic diseases such as allergic rhinitis and allergic conjunctivitis. Aim of the research: To compare the effectiveness of selected antihistamines and frequency of side effects in the course of their therapy in the patient opinion. Material and methods: The study was conducted on a group of 40 patients taking rupatadine, bilastine, levocetirizine and fexofenadine. The method of diagnostic survey was used, having the character of a preliminary examination in view of the small number of people involved in the study. Results: Among the 40 patients, side effects of the medicines only appeared in 3 respondents, which is 1.2%. Conclusions:The new generation antihistamines in light of our studies appear to be safe and associated with few side effects. Due to the small number of surveyed people we treat these tests as preliminary to further analysis of the effectiveness of selected antihistamines.

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Section: Discussionmentioning

confidence: 96%

Second generation antihistamines: assessment of the efficacy of treatment and tolerance of some preparations of this group (preliminary studies)

Czarny-Działak¹,

Głuszek-Osuch²

2016

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“…Serum samples from age-and sex-matched healthy donors, who were confirmed to be negative in RAST for the above allergens with no clinical symptoms, were used as a control. Scoring of severity in allergic rhinitis was made by the criteria reported previously (14). This research was carried out in accordance with the human experimentation guidelines of our institution and the Helsinki Declaration.…”

Section: Methodsmentioning

confidence: 99%

“…: patient number, HD: house dust. Severity of allergic rhinitis was scored by the criteria reported previously (14).…”

Section: Detection Of Self Proteins Reactive To Sera From Patients Wimentioning

confidence: 99%

Identification of β‐Tubulin Isoform V as an Autoantigen in Allergic Rhinitis by a Proteomic Approach

Nakamura

Tsutsumi

Ooka

et al. 2004

Microbiology and Immunology

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Type I allergic rhinitis, an inflammatory condition of upper airways, often impairs quality of life of sufferers, even though it is not a life-threatening disease (25). For example, the disease results in decreased productivity and potential absenteeism from work or schooling (2). Prevalence of allergic rhinitis appears to be increasing. Possible factors for this would be increases in airborne pollution, increases in dust mite populations, changes in living and dietary conditions, control of infectious diseases and vaccinations (4,15,22,23).On pathogenesis of allergic rhinitis, major interest has been centered on immunological disorders of massive production of allergen-specific IgE antibodies and proallergic mediators including histamine (9, 15). However, the role of autoimmunity has been also implicated recently (16,21,24,26,27). Specifically, autoantibodies to IgE and β2-adrenergic receptors were reported in patients with allergic rhinitis (24, 27). Possible pathological roles of these autoantibodies have not been confirmed yet; rather, it remains even to be resolved whether autoimmunity in allergic rhinitis is directed selectively to IgE and/or β2-adrenergic receptors or directed to a wide range of self proteins. To address this question here we surveyed autoantibodies/autoantigens in allergic rhinitis using a proteomic approach. Specifically, proteins extracted from human peripheral blood mononuclear cells (PBMC) were separated by two-dimensional electrophoresis (2DE), and then were subjected to western blotting (WB) with serum samples from patients with allergic rhinitis. Then detected autoantigens were identified by mass fingerprinting. One of the identified proteins was found to be β-tubulin isoform V (β-tubV), which was found to be recognized as an autoantigen in 52% of the tested patients with allergic rhinitis by WB using recombinant β-tubV. Abstract: Autoantibodies to IgE and ␤2-adrenergic receptor have been reported in patients with allergic rhinitis. To investigate whether autoimmunity in allergic rhinitis is directed to such limited molecules or directed to a wide range of self proteins, we here attempted to survey autoantigens/autoantibodies comprehensively, using proteomics. Specifically, we separated proteins extracted from peripheral blood mononuclear cells by 2-dimensional electrophoresis and then detected autoantigens by subsequent western blotting with sera from patients with allergic rhinitis. As a result, we detected multiple autoantigens, some of which were further identified by mass fingerprinting. Next, we confirmed antigenicity of one of the identified autoantigens, ␤-tubulin isoform V (␤-tubV), using a recombinant protein and then measured prevalence of the anti-␤-tubV autoantibodies. As a result, 52% of the tested patients with allergic rhinitis were found to possess anti-␤-tubV autoantibodies. Our study indicates that autoimmunity is a common phenomena and ␤-tubV is one of the major autoantigens in allergic rhinitis. Identification of ␤-Tubulin

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“…They found no electrocardiogram abnormalities at peak plasma concentrations. Miyabe et al (2003) studied the effect of fexofenadine upon cedar pollinosis. They found that fexofenadine administered before or after the onset of cedar pollinosis prevented or controlled nasal obstruction, sneeze, and rhinorrhea.…”

Section: Effi Cacy and Safetymentioning

confidence: 99%

Fexofenadine hydrochloride in the treatment of allergic disease: a review

Bielory¹

2008

JAA

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Fexofenadine is a selective, non-sedating H1 receptor antagonist, marketed in the United States since 2000. The FDA approved an oral suspension in 2006, for the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria in children. The tablet, capsule, and oral suspension are bioequivalent. Although fexofenadine does not use P450 CYP 3A4 it does interact with a number of drugs at P-glycoprotein and organic anion transporter polypeptides. The risk of toxicity from other drugs may increase with the administration of fexofenadine. Orange and grapefruit juices reduce the bioavailability of fexofenadine. Fexofenadine has been shown to have an impact on infl ammatory mediators, other than histamine, such as decreasing the production of LTC 4 , LTD 4 , LTE 4 , PGE 2 , and PGF 2α ; inhibiting cyclo-oxygenase 2, thromboxane; limiting iNOS generation of NO; decreasing cytokine levels (ICAM-1, ELAM-1, VCAM-1, RANTES, I-TAC, MDC, TARC, MMP-2, MMP-9, tryptase); and diminishing eosinophil adherence, chemotaxis, and opsonization of particles. These effects may provide benefi t to some of the infl ammatory responses of an acute allergic reaction and provide a basis for future development of H1 antagonists with stronger anti-infl ammatory effects. These studies also support the contention that fexofenadine is effective for the treatment of allergic rhinits and chronic idiopathic urticaria.

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Effect of fexofenadine hydrochloride on cedar pollinosis

Cited by 5 publications

References 8 publications

Second generation antihistamines: assessment of the efficacy of treatment and tolerance of some preparations of this group (preliminary studies)

Second generation antihistamines: assessment of the efficacy of treatment and tolerance of some preparations of this group (preliminary studies)

Identification of β‐Tubulin Isoform V as an Autoantigen in Allergic Rhinitis by a Proteomic Approach

Fexofenadine hydrochloride in the treatment of allergic disease: a review

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