Effect of fish oil fatty acids on LDL size, oxidizability and uptake by macrophages

Suzukawa, Michio; Abbey, Mavis; Nestel, Paul J.

doi:10.1016/0021-9150(94)93308-1

Cited by 62 publications

(94 citation statements)

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“…They reported that EPA and DHA are equally effective at reducing serum triglyceride, but that DHA only raised HDL cholesterol (specifically the HDL 2 fraction). Furthermore they also find that LDL particle size increased significantly with DHA supplementation, a finding reported by other authors [39,40]. Since small, dense LDL particles are associated with an increased risk of coronary artery disease [41] these changes might be expected to contribute to a reduction in atherogenic risk.…”

Section: Biological Effects Of N-3 Fa Related To Cvdsupporting

confidence: 55%

“…The biological effects of n-3 FA on atherosclerosis include preventing arrhythmias [8,12,[19][20][21][22][23][24], decreasing platelet aggregation [27][28][29], lowering plasma triglycerides [30][31][32][33][34][35], increasing HDL cholesterol and LDL particle size [36][37][38][39][40], decreasing blood pressure [42][43][44][45], reversing cholesterol accumulation from atheromatous plaques [46,47] and decreasing inflammation [48][49][50].…”

Section: Biological Effects Of N-3 Fa Related To Cvdmentioning

confidence: 99%

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n-3 Fatty acids and cardiovascular disease: Actions and molecular mechanisms

Torrejón

Jung

Deckelbaum

2007

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Section: Biological Effects Of N-3 Fa Related To Cvdsupporting

confidence: 55%

Section: Biological Effects Of N-3 Fa Related To Cvdmentioning

confidence: 99%

n-3 Fatty acids and cardiovascular disease: Actions and molecular mechanisms

Torrejón

Jung

Deckelbaum

2007

Prostaglandins, Leukotrienes and Essential Fatty Acids

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“…This finding might have been influenced by the intervention design, which, according to published data (Suzukawa et al, 1995;Nestel, 2000), included enough vitamin E supplemented to avoid increased oxidizability of LDL.…”

Section: Discussionmentioning

confidence: 99%

Effects of marine n-3 fatty acid supplementation on lipoprotein subclasses measured by nuclear magnetic resonance in subjects with type II diabetes

et al. 2007

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Objective: To measure effects of fish oil supplements on lipoprotein subclasses by nuclear magnetic resonance (NMR) in subjects with type II diabetes and relate them to insulin sensitivity. Design: Two-armed, parallel, placebo-controlled, randomized. Subjects: Normotriglyceridemic subjects with type II diabetes without insulin treatment were given either fish oil (n ¼ 12, median intake 5.9 g/day total n-3 fatty acids (FA) (1.8 g 20:5n-3, 3.0 g 22:6n-3)) or corn oil (n ¼ 14, 8.5 g/day 18:2n-6 FA). Methods: Size and concentration of lipoproteins subclasses were measured by NMR, insulin sensitivity by hyperinsulinemic, isoglycemic clamps. Results: After 9 weeks, there were differences between those treated with fish and corn oil with respect to very low-density lipoprotein (VLDL) size (median À15 vs þ 0.6%, P ¼ 0.001), particle concentrations of large VLDL (À99 vs À4.1%, P ¼ 0.041) and small high-density lipoprotein (HDL) (À12 vs þ 10%, P ¼ 0.051). Compared with corn oil fish oil tended to increase HDL size and small low-density lipoprotein ( LDL) concentration (P ¼ 0.063 and 0.068, respectively, for differences between groups). There was no effect on oxidized LDL. Insulin sensitivity (glucose utilization) decreased in the fish oil group compared with the corn oil group (P ¼ 0.049). The decrease in insulin sensitivity did not correlate with the effects on lipoprotein subclasses. Conclusions: A high intake of n-3 FA exerts effects on several lipoprotein subclasses without obvious influence from changes in insulin sensitivity.

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“…The influence of DHA supplementation on the production of F 4 -isoprostanes needs further evaluation. Some studies showing increased peroxidation and oxidative stress by n-3 fatty acid supplementation were suggested by an increase of LDL oxidation in vitro (Oostenbrug et al, 1994;Suzukawa et al, 1995). However, when similar assay was used to examine whether the observed unchanged in vivo oxidative stress status may be corroborated in vitro, results showed that the level of LDL-TBARS increased by DHA supplementation (Table 4).…”

Section: Lipid Peroxidesmentioning

confidence: 95%

Effects of docosahexaenoic acid supplementation on blood lipids, estrogen metabolism, and in vivo oxidative stress in postmenopausal vegetarian women

Wang

et al. 2005

Eur J Clin Nutr

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Background: Vegetarians are generally deficient in long-chain n-3 fatty acids. Long-chain n-3 fatty acids have a beneficial effect on plasma lipid levels, and some studies showed that they had breast cancer suppression effect. One of the biomarkers of breast cancer risk is the ratio of urinary 2-hydroxyestrone (2-OHE 1 ) to 16a-hydroxyestrone (16a-OHE 1 ). Objective: To investigate the effect of docosahexaenoic acid (DHA, 22:6n-3) supplementation on blood lipids, estrogen metabolism and oxidative stress in vegetarians. Design: Single-blind, randomized, placebo-controlled trial. Interventions: Twenty-seven postmenopausal vegetarian women were recruited. After a 2-week run-in period with 6 g placebo corn oil, the subjects were subsequently randomized to receive either 6 g corn oil (n ¼ 13) or 6 g DHA-rich algae oil (2.14 g of DHA/day) (n ¼ 14) for 6 weeks. Two subjects in corn oil group withdrew before completion. Main outcome measures: Plasma lipids, urinary 2-OHE 1 and 16a-OHE 1 , urinary F 2 -isoprostanes and plasma a-tocopherol. Results: Plasma LDL-DHA and EPA level increased significantly by DHA supplementation. DHA decreased plasma cholesterol (C) levels (P ¼ 0.04), but did not influence the levels of plasma TG, LDL-C and HDL-C, a-tocopherol, urinary F 2 -isoprostanes, 2-OHE 1 , 16a-OHE 1 and ratio of 2-OHE 1 to 16a-OHE 1 as compared to corn oil. Conclusion: DHA supplementation at a dose of 2.14 g/day for 42 days decreases plasma cholesterol but neither does it show beneficial effects on estrogen metabolism, nor does it induce deleterious effects on the observed in vivo antioxidant or oxidative stress marker in postmenopausal vegetarian women.

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Effect of fish oil fatty acids on LDL size, oxidizability and uptake by macrophages

Cited by 62 publications

References 0 publications

n-3 Fatty acids and cardiovascular disease: Actions and molecular mechanisms

n-3 Fatty acids and cardiovascular disease: Actions and molecular mechanisms

Effects of marine n-3 fatty acid supplementation on lipoprotein subclasses measured by nuclear magnetic resonance in subjects with type II diabetes

Effects of docosahexaenoic acid supplementation on blood lipids, estrogen metabolism, and in vivo oxidative stress in postmenopausal vegetarian women

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