Effect of Fish Oil on Heart Rate in Humans

Mozaffarian, Dariush; Geelen, Anouk; Brouwer, Ingeborg A.; Geleijnse, Johanna M.; Zock, P.L.; Katan, Martijn B.

doi:10.1161/circulationaha.105.556886

Cited by 351 publications

(131 citation statements)

References 58 publications

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“…Raised HR per se is a risk factor for CVD (16) . A recent study utilising the HR-lowering drug ivabradine has found that reducing HR below 70 bpm reduced the incidence of CHD (25) .…”

Section: Discussionmentioning

confidence: 99%

“…There is strong evidence that regular consumption of LC n-3 PUFA can also reduce HR. In a meta-analysis of thirty-two trials, Mozaffarian et al (16) found that fish oil consumption for greater than 12 weeks reduced HR, particularly with groups that had a resting HR equal to or above 69 bpm. However, in the present study, we did not find a significant reduction in resting HR, perhaps because resting HR in the present study was below 69 bpm for each group.…”

Section: Discussionmentioning

confidence: 99%

“…Supplementation of the diet with fish oil containing LC n-3 PUFA has previously been shown to reduce TAG and HR (15,16) and improve HRV (17 -19) . Epidemiological evidence also suggests that HRV is improved in populations that have a higher intake of LC n-3 PUFA over a prolonged period (20) .…”

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confidence: 99%

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Dose-dependent increases in heart rate variability and arterial compliance in overweight and obese adults with DHA-rich fish oil supplementation

et al. 2009

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Heart rate (HR) variability and large arterial compliance can be improved using fish oils. DHA, a component of fish oil, has cardiovascular health benefits, but its effect on HR variability (HRV) and arterial compliance is yet to be quantified. Sixty-seven overweight or obese adults (thirty-six males and thirty-one females; 53 (SEM 2) year; BMI 31·7 (SEM 1·1) kg/m 2 ) were randomly allocated to consume either 6 g/d sunola oil (control; n 17), fish oil (260 mg DHA þ 60 mg EPA per g) at doses of 2 g/d (n 16), 4 g/d (n 17) or 6 g/d (n 17). Blood pressure, HR and compliance of large and small arteries were measured while supine at baseline and after 12 weeks in all participants, and HRV was assessed in a subgroup of forty-six participants. There was no effect of fish oil on blood pressure, small artery compliance or HR. However, the low frequency:high frequency ratio of HRV decreased with increasing doses of fish oil (r 20·34, P¼0·02), while large artery compliance increased (r 0·34, P¼ 0·006). Moreover, the changes in these biomarkers were significantly correlated (r 2 0·31, P¼ 0·04) and may reflect fish oil-induced improvements in arterial function and cardiac autonomic regulation.

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“…Raised HR per se is a risk factor for CVD (16) . A recent study utilising the HR-lowering drug ivabradine has found that reducing HR below 70 bpm reduced the incidence of CHD (25) .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Dose-dependent increases in heart rate variability and arterial compliance in overweight and obese adults with DHA-rich fish oil supplementation

et al. 2009

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“…A recent systematic review measured changes in heart rate after n-3 PUFA combining all patients groups, and including two trials with patients with type 2 diabetes, showing pooled reductions of about 2 beats/min [53]. In the population-based study, 4 beats/min was shown to be the difference between patients who died a sudden death and the controls.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of the effects of n-3 polyunsaturated fatty acids on haematological and thrombogenic factors in type 2 diabetes

et al. 2006

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Aim/hypothesis To determine whether marine-derived n-3 polyunsaturated fatty acids (n-3 PUFA) (also known as omega-3 fatty acids) have beneficial effects on haematological and thrombogenic risk markers in addition to dyslipidaemia, in patients with type 2 diabetes. Methods A systematic review and meta-analysis of randomised controlled trials comparing dietary or nondietary intake of n-3 PUFA with placebo in type 2 diabetes was conducted by systematically searching databases from 1966 to February 2006. Changes in C-reactive protein, IL-6, TNF-α, platelet function, fibrinogen, factor VII, von Willebrand factor, endothelial function, heart rate and blood pressure were recorded. Inclusion of studies, data extraction and quality were assessed independently in duplicate. Results Twelve trials involving 847 subjects with a mean treatment duration of 8.5 weeks included sufficient data to permit pooling. Compared with placebo, n-3 PUFA supplementation had a significant effect on two outcomes: reducing the level of diastolic blood pressure (five trials, 248 subjects) by a mean of 1.8 mm Hg (95% CI 0.0-3.6, p=0.05) and increasing factor VII (two trials, 116 subjects) by 24.9% (95% CI 7.2-42.6, p=0.006). There were no significant effects on systolic blood pressure, fibrinogen or heart rate. Conclusions/interpretation These results suggest that, in addition to the recognised effects on dyslipidaemia, n-3 PUFA decreases diastolic blood pressure, and appears to increase factor VII. Larger and more rigorously conducted clinical trials are required to establish conclusively the role of n-3 PUFA in cardiovascular risk markers and clinical outcomes in type 2 diabetes.

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“…The biological effects of n-3 FA on atherosclerosis include preventing arrhythmias [8,12,[19][20][21][22][23][24], decreasing platelet aggregation [27][28][29], lowering plasma triglycerides [30][31][32][33][34][35], increasing HDL cholesterol and LDL particle size [36][37][38][39][40], decreasing blood pressure [42][43][44][45], reversing cholesterol accumulation from atheromatous plaques [46,47] and decreasing inflammation [48][49][50].…”

Section: Biological Effects Of N-3 Fa Related To Cvdmentioning

confidence: 99%