Effect of Fish Scale Collagen on Some Characteristics and Drug Release of Carrageenan/Collagen/Allopurinol Film

Nguyen, Chinh Thuy; Tran, Mai; Vu, Manh Quoc; Nguyen, Tran; Tran, Trang Do Mai; Vu, Trung Quoc; Ha, Hang Van; Hoàng, Thái

doi:10.15625/2525-2518/57/3b/14044

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…As compared to the allopurinol released from CCA biocomposite films which were prepared by solution casting in our previous report [50], a similar tendency can be observed, meaning that the amount of allopurinol released from composite films in the pH 7.4 solution was higher than that in the pH 2.0 solution. This can be explained by the protonation of amine groups of collagen, which leads to the formation of a proton layer around the film, resulting in inhibiting the diffusion of a drug through the polymer films into the solution [23,31].…”

Section: Drug Release Process Of Allopurinol Fromsupporting

confidence: 79%

“…This also contributes to the increase in the amount of drug released from the CCA biocomposite films in the pH 7.4 solution. However, if there is an evaluation of the effect of the preparation method on drug release from carrageenan/collagen/allopurinol films, the ionic gelation method combined with the 3D printing method exhibits a better solubility enhancement of allopurinol through a higher amount of allopurinol release as compared to the solution casting method [50]. This could be due to the better 7 International Journal of Polymer Science interaction of components as prepared by the ionic gelation method and the more regular structure of films prepared by the 3D printing method.…”

Section: Drug Release Process Of Allopurinol Frommentioning

confidence: 99%

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A Novel Method for Preparation of Carrageenan/Fish Scale Collagen/Allopurinol Biocomposite Film

Nguyen

Dam

et al. 2021

International Journal of Polymer Science

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Biopolymers such as carrageenan or collagen can be used as carriers for loading a drug to enhance a drug’s bioavailability. In this work, allopurinol was loaded on a carrageenan/collagen blend and the carrageenan/collagen/allopurinol (CCA) biocomposite films were prepared using the ionic gelation method combined with the 3D printing method using carrageenan/collagen/allopurinol gel as a 3D printing ink material. The advantages of the 3D printing method are the ease in shaping the design of films and the ease in controlling the thickness of films. The results of infrared (IR) spectroscopy and field emission scanning electron microscopy (FESEM) analyses showed that the CCA biocomposite films have a regular structure, and the functional groups of components in the biocomposites can interact with each other. After 30 minutes of immersion in distilled water and pH buffer solution, the biocomposite films swelled and disintegrated. The carrageenan/collagen blend can control the release of allopurinol in simulated body fluids. In addition, the drug release kinetic models reflecting the release process of allopurinol from CCA biocomposite films in simulated body fluids have also been calculated.

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Section: Drug Release Process Of Allopurinol Fromsupporting

confidence: 79%

Section: Drug Release Process Of Allopurinol Frommentioning

confidence: 99%

A Novel Method for Preparation of Carrageenan/Fish Scale Collagen/Allopurinol Biocomposite Film

Nguyen

Dam

et al. 2021

International Journal of Polymer Science

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Evaluation of the effect of the chitosan/carrageenan ratio on lovastatin release from chitosan/carrageenan based biomaterials

Hung,

Manh,

Thao

et al. 2022

Vietnam Journal of Chemistry

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The chitosan/carrageenan/lovastatin biomaterials were prepared using a solution technique with 5 % lovastatin and a variable chitosan/carrageenan mass ratio. Fourier transform infrared spectroscopy (FT‐IR) and field emission scanning electron microscopy (FESEM) images revealed that the complex's components were well dispersed into each other without changing the chemical structure, forming dipole interactions and hydrogen bonds among them. The abilities to release Lovastatin (Lov) in pH 2 and pH 7.4 solutions, corresponding to the environments in stomach and intestinal fluids, respectively, are both affected by the ratio of polymer components. The best results were obtained with the chitosan/carrageenan/lovastatin (w/w/%w = 10/90/5%) (CsCL195) biomaterial sample in which the particles are evenly dispersed. While the drug release process was poor in the pH 2 solution (gastric juice), a good release observed in the pH 7.4 solution (intestinal fluid) allows facilitating drug absorption through the intestinal mucosa cells into the blood, from which the effects of hypercholesterolemia treatment can be obtained.

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Preparation and characterization of materials based on fish scale collagen and polyphenols extracted from Camellia chrysantha

Nguyen

Huynh

et al. 2023

Vietnam J. Sci. Technol.

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This paper presents the preparation and some characteristics of collagen/polyphenols materials containing different polyphenols contents. Collagen was extracted from fresh-water fish scales and polyphenols were extracted from Camellia chrysantha (Tam Dao, Vinh Phuc, Viet Nam). A comparison between these polyphenols and green tea polyphenols (commercial product) was carried out in this study. Functional groups and morphology of collagen/polyphenols materials were determined by Infrared spectroscopy (IR) and scanning electron microscope (SEM). Ultraviolet-visible spectroscopy (UV-Vis) was used to evaluate the release of polyphenols from collagen/polyphenols materials in simulated body fluids. In addition, the anti-oxidation ability of collagen/polyphenols materials was also investigated by 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging method. The obtained results showed that polyphenols with the size of ca. 100 nm were dispersed and adhered well to the collagen matrix. The release of polyphenols from the materials follows two stages: fast release during the first 2 hours of testing and controlled release in the following hours. The content of polyphenols released from the collagen/polyphenols materials in pH 2.0 solution was higher than that in pH 7.4 solution. After 8 hours of testing, the content of polyphenols released from the collagen/polyphenols materials reached 15-65 % depending on the polyphenols content, type of polyphenols and pH of solution. The anti-oxidation ability of polyphenols extracted from Camellia chrysantha is better than that of green tea polyphenols and collagen/polyphenols materials.

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Effect of Fish Scale Collagen on Some Characteristics and Drug Release of Carrageenan/Collagen/Allopurinol Film

Cited by 4 publications

References 10 publications

A Novel Method for Preparation of Carrageenan/Fish Scale Collagen/Allopurinol Biocomposite Film

A Novel Method for Preparation of Carrageenan/Fish Scale Collagen/Allopurinol Biocomposite Film

Evaluation of the effect of the chitosan/carrageenan ratio on lovastatin release from chitosan/carrageenan based biomaterials

Preparation and characterization of materials based on fish scale collagen and polyphenols extracted from Camellia chrysantha

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