Effect of flapless osteoperforation-assisted tooth movement on atrophic alveolar ridge: Histomorphometric and gene-enrichment analysis

Abstract

Objective: To investigate the effect of flapless osteoperforation on the tissue response of the atrophic alveolar ridge affected by orthodontic tooth movement (OTM). Materials and Methods: An atrophic alveolar ridge model was established in the mandibular quadrants of eight beagle dogs. As a split-mouth design, the quadrants were randomly divided into group C (OTM only) and group OP (OTM with flapless osteoperforation). The rate of OTM for 10 weeks was compared between groups, and micro-CT-based histomorphometric analysis and RNAsequencing-based gene-enrichment analysis were performed targeting the atrophic ridge. Results: Group OP displayed more rapid tooth movement with lower bone mineral density and higher trabecular fraction in the atrophic ridge than did group C, showing no intergroup difference of total ridge volume. As contributing biological functional pathways in group OP, the genes related to osteoclast differentiation and TNF signaling pathway were up-regulated and those associated with Wnt signaling pathway and AMPK signaling pathway were down-regulated. Conclusions: Flapless osteoperforation facilitated the rate of OTM toward the atrophic ridge, maintaining low bone density, whereas it did not increase the volume of the atrophic ridge. (Angle Orthod. 2018;88:82-90.)

The effect of different micro-osteoperforation depths on the rate of orthodontic tooth movement: A single-center, single-blind, randomized clinical trial

“…Some studies have demonstrated that MOP is a safe method 8 that may facilitate root movement, 16 induce cellular activity, and accelerate tooth movement 8 , 17 , 18 without causing bacteremia. 19 Flapless osteoperforations have been reported to increase the rate of orthodontic tooth movement toward the atrophic ridge, while maintaining a low bone density 20 and without an increased risk of root resorption. As a minimally invasive, flapless surgical intervention, MOP using miniscrews improve patient acceptance and reduce surgical risks.…”

Effect of micro-osteoperforation on the rate of canine retraction: a split-mouth randomized controlled trial

“…This minor surgical procedure was first introduced by Teixeira et al [6], who hypothesized that limited cortical bone perforations were sufficient to elicit RAP, hence accelerating OTM. Nevertheless, later experimental studies [7–10] have shown conflicting evidence regarding its acceleratory effect.…”

Effects of mini-implant facilitated micro-osteoperforations in alleviating mandibular anterior crowding: A randomized controlled clinical trial

“…To the best of our knowledge, this is the first well-designed RCT to investigate the effectiveness of MI-facilitated MOPs in accelerating mandibular anterior teeth alignment along with patient's pain and satisfaction. [56789] Marginal alveolar bone height loss and volumetric root resorption which has not been assessed in any of the previous studies was also assessed in our study using CBCT.…”