Effect of flavonoids morin; quercetin and nicotinic acid on lipid metabolism of rats experimentally fed with triton

Abstract

Atherosclerosis is a coronary disease where deposition of lipids in the arteries leads to problems of blood circulation. The present work evaluates the action of the flavonoids morin, quercetin and nicotinic acid isolated in association on lipid metabolism in hyperlipidemic rats. Blood serum levels cholesterol, cholesterol-HDL, and triacylglycerids have been analysed following the intraperitoneal administration of the flavonoid compounds dissolved in propyleneglycol by in doses of

Effect of quercetin against lindane induced alterations in the serum and hepatic tissue lipids in wistar rats

“…This is in accordance with the previous study where quercetin presented the largest percentual reduction of cholesterol in the triton induced hyperlipidemic rats [47] . Quercetin is found to decrease the ceramide accumulation, lipid peroxidation [48] and restore the lipid profiles to normal [49] .…”

Effects of Dietary Quercetin on Growth Performance, Serum Lipids Level and Body Composition of Tilapia (Oreochromis Niloticus)

“…They also found that TC levels in flounder fed diets contained quercetin were significantly lower after 60 days compared with 30 days. Moreover, similar results about quercetin in the reduction of serum or hepatic lipids were previously reported in rats (Basarkar and Nathn, 1983;Igarashi and Ohmura, 1995;Ricardo et al, 2001;de Boer et al, 2006;Krishnaveni et al, 2010;Hu et al, 2012;Padma et al, 2012), mice (Kobori et al, 2011;Zhang et al, 2012), chicken (Qureshi et al, 2011) , rabbits (Kamada et al, 2005) and humans (Arai et al, 2000;Egert et al, 2010) . Yugarani et al (1992) found that quercetin did not cause any significant changes on the plasma TC, TG and liver fat at weeks 4, 7 and 10 in the rats fed high fat diet, and Nakamura et al (2000) also indicated that oral quercetin (1.0g/kg) had no remarkable influence on lipid concentrations of serum and hepatic and fecal steroid excretion in rats.…”

“…Those two reports are not consistent with the results in present study, it might be caused by the differences of animal species, dietary lipid level, dietary quercetin level, quercetin sources and trial period duration. Ricardo et al (2001) concluded that quercetin showed potential activities in the reduction of cholesterol and triacylglycerid levels. Moon et al (2012) found that up-regulation of LDL receptors by quercetin could effectively lower blood concentrations of LDL-cholesterol; their study demonstrates that quercetin strongly up-regulated LDL receptors gene expression by activating c-jun-N-terminal kinase and extracellular signal-regulated kinase signalling pathways and increasing nuclear sterol regulatory element binding protein2 levels, which might elicit hypolipidemic effects by increasing the clearance of circulating LDL cholesterol levels from the blood.…”

“…In addition to the antioxidant properties of oral administration of quercetin, there is potential effect on lowering levels of lipid in mammal animals (Basarkar and Nathn 1983;Igarashi and Ohmura 1995;Ricardo et al, 2001;Kamada et al 2005;de Boer et al, 2006;Krishnaveni et al, 2010;Kobori et al, 2011;Hu et al, 2012;Padma et al, 2012;Zhang et al, 2012) and poultry (Qureshi et al, 2011). However, there also seemed no remarkable influence on serum and hepatic lipid concentrations of rats (Ruttus norvegicus) (Yugarani et al, 1992;Nakamura et al, 2000).…”

Flavonoid: A Pharmacologically Significant Scaffold

“…Gastroprotective Hypoglycemic [77,78] 27 Liquiritin Glyccheriza glabra (Leguminaceae) Antidepressant [79] Antioxidant Anti-spermatogenic [84] 31 Myricetin Betula pendula (Betulaceae) Anti-inflammatory [68] 32 Naringin Citrus medica (Rutaceae) Anti-depression [62] 33 Orientin…”