Effect of flaxseed supplementation on lipid profile: An updated systematic review and dose-response meta-analysis of sixty-two randomized controlled trials

Hadi, Amir; Askarpour, Moein; Salamat, Shekoufeh; Ghaedi, Ehsan; Symonds, Micheal E.; Miraghajani, Maryam

doi:10.1016/j.phrs.2019.104622

Cited by 48 publications

(41 citation statements)

References 82 publications

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“…Our present results on TC, LDL-C and TG in patients with dyslipidemia related diseases were consistent with a meta-analysis [ 13 ] that studied on the whole population. Whole flaxseed was an essential source of high-quality protein and soluble fiber [ 54 ], which contained 41% fat, 20% protein, and 28% fiber [ 55 ].…”

Section: Discussionsupporting

confidence: 92%

“…In recent years, the health effect of flaxseed intervention has aroused great concern in China. There was also a meta-analysis to evaluate the flaxseed effects on blood lipid [ 13 ], and several studies evaluated the reducing-inflammation effect regardless of supplement dosage [ 14 , 15 ]. But few meta-analyses considered the health background of participants i.e., health or be with chronic disease, and almost of them ignored the effect on weight loss of flaxseed intervention.…”

Section: Introductionmentioning

confidence: 99%

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Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose–response meta-analysis of randomized controlled trials

et al. 2021

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Background Flaxseed is widely used as a functional food for its rich sources of linolenic acid, lignans and dietary fibers in the world. This systematic review and dose–response meta-analysis on randomized controlled trials (RCTs) is first to evaluate effects of different flaxseed products (whole flaxseed, oil and lignans) on lipid profiles, inflammatory and anthropometric parameters in patients with dyslipidemia related diseases. Methods Literature search was performed in PubMed, Embase, Cochrane Central, Scopus, and Web of Science from the inception dates to January, 2020. Weighted mean differences with the 95% confidence interval (CI) were pooled using fix or random-effects models. Results Thirty-one RCTs involving 1,698 participants were included. The present meta-analysis revealed that flaxseed consumption had an overall beneficial effect on serum TC, LDL-C, TG, apo B and IL-6 in patients with dyslipidemia related diseases, but not on apo A, HDL-C, hs-CRP, CRP and anthropometric indices. However, different flaxseed products showed obviously different effects. Whole flaxseed supplementation significantly reduced TC (− 11.85 mg/dl, 95% CI − 20.12 to − 3.57, P = 0.005), LDL-C (− 10.51 mg/dl, 95% CI − 14.96 to − 6.06, P < 0.001), TG (− 19.77 mg/dl, 95% CI − 33.61 to − 5.94, P = 0.005), apolipoprotein B (− 5.73 mg/dl, 95% CI − 7.53 to − 3.93, P < 0.001), TC/HDL-C (− 0.10, 95% CI − 0.19 to − 0.003, P = 0.044) and weight (− 0.40 kg, 95% CI − 0.76 to − 0.05, P = 0.027); Lignans supplementation significantly reduced TC (− 17.86 mg/dl, P = 0.004), LDL-C (− 15.47 mg/dl, P < 0.001) and TC/HDL-C (− 0.45, P = 0.04). Although flaxseed oil supplementation had no such lowering-effect on lipid, meta-analysis revealed its lowering-effect on IL-6 (− 0.35 pg/ml, P = 0.033) and hs-CRP (− 1.54 mg/l, P = 0.004). Subgroup analysis revealed that whole flaxseed decreased TC, LDL-C and TG levels irrespective of country and the intervention time prescribed, but was more pronounced when the dose of whole flaxseed was ≤ 30 g/day (TC: WMD − 13.61 mg/mL; LDL-C: WMD − 10.52 mg/mL; TG: WMD − 23.52 mg/mL), rather not a dose > 30 g/day. Moreover, a linear relationship between dose of whole flaxseed and absolute changes in C-reactive protein (P = 0.036) and a nonlinear relationship between with IL-6 (P < 0.001) were detected. Conclusions Flaxseed intervention suggested the positive effects on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases. Of these, whole flaxseed and lignans play an important role in reducing blood lipid, while flaxseed oil mainly plays in anti-inflammatory. Lipid- and weight-lowering was significant when whole flaxseed was consumed at doses < 30 mg/d, for lipid status with mixed dyslipidemia and patients with BMI > 25. Graphic abstract

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose–response meta-analysis of randomized controlled trials

et al. 2021

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“…Results from reviews and metanalyses show that flaxseed consumption has beneficial effects on blood pressure [274], lipid profile [275] and glucose metabolism [276]. Evidence regarding its effect on body composition indices, however, is controversial [277].…”

Section: Flaxseedmentioning

confidence: 99%

Current Evidence to Propose Different Food Supplements for Weight Loss: A Comprehensive Review

et al. 2020

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The use of food supplements for weight loss purposes has rapidly gained popularity as the prevalence of obesity increases. Navigating through the vast, often low quality, literature available is challenging, as is providing informed advice to those asking for it. Herein, we provide a comprehensive literature revision focusing on most currently marketed dietary supplements claimed to favor weight loss, classifying them by their purported mechanism of action. We conclude by proposing a combination of supplements most supported by current evidence, that leverages all mechanisms of action possibly leading to a synergistic effect and greater weight loss in the foreseen absence of adverse events. Further studies will be needed to confirm the weight loss and metabolic improvement that may be obtained through the use of the proposed combination.

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“…Em virtude da sua composição nutricional, a linhaça é estudada como uma possível aliada na redução de risco de doenças crônicas não transmissíveis (DCNT). São reportados na literatura vários benefícios associados ao seu consumo regular, entre eles efeitos hipocolesterolemiante (SAXENA & KATARE, 2014;KAWAKAMI et al, 2015;AKRAMI et al, 2018;PRASAD et al, 2020;HADI et al, 2020a), hipoglicemiante ZHU et al, 2020;KUANG et al, 2020), anti-hipertensivo (URSONIU et al, 2016 anticancerígeno (DE SILVA & ALCORN, 2019;PAL et al, 2019;TANNOUS et al, 2020), antioxidante (BIAO et al, 2020), redutor da inflamação (BASHIR et al, 2019;ASKARPOUR et al, 2020;PALLA et al, 2020 ) e laxativo (PARIKH et al, 2019).…”

Section: Composição Nutricionalunclassified

“…Alguns estudos observaram que as lignanas podem exercer efeitos sobre a redução da trigliceridemia, na relação cintura-quadril (RCQ), na lipoproteína (a) [Lp(a)] e em alguns marcadores inflamatórios como a proteína C reativa (PCR) (HALLUND et al, 2008;HADI et al, 2020b). As lignanas atuam ainda no metabolismo de ácidos biliares, aumentando a sua excreção e reduzindo a absorção de colesterol de origem alimentar (HADI et al, 2020a).…”

Section: Lignanasunclassified

Histórico, Usos E Importância Econômica Da Linhaça

Lúcio¹,

Follmann²,

Emanuelli³

et al. 2021

Linhaça: Perspectiva De Produção E Usos Na Alimentação Humana E Animal

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Direitos para esta edição cedidos à Atena Editora pelos autores. Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0).O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais. Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica.A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

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Effect of flaxseed supplementation on lipid profile: An updated systematic review and dose-response meta-analysis of sixty-two randomized controlled trials

Cited by 48 publications

References 82 publications

Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose–response meta-analysis of randomized controlled trials

Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose–response meta-analysis of randomized controlled trials

Current Evidence to Propose Different Food Supplements for Weight Loss: A Comprehensive Review

Histórico, Usos E Importância Econômica Da Linhaça

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