Effect of fluid resuscitation on acute lung injury in a rat model of sepsis

Abstract

AIM: Sepsis is a systemic infection reaction and intravascular volume therapy plays a crucial role in it's treatment. Acute respiratory distress syndrome (ARDS) occurs in the lungs, the most affected organ. This study aimed to investigate the different effects of fl uid therapy on ARDS caused by sepsis. METHOD: To form a sepsis model, cecal ligation and puncture (CLP) procedure were performed on 44 adult rats. Divided into six groups; normal, CLP group, those treated with 40 ml/kg 0.9 % NaCl, 3 % NaCl (hypertonic saline), Ringer Lactate and Hydroxyethyl starch. After 24 hours treatments, histopathological examination of the lungs were done, and the plasma levels of CRP, TNF-α and IL-6 and paO 2 were measured. RESULTS: The scores of all histological parameters of the group treated with hypertonic saline were signifi cantly lower than of the other groups (p < 0.001). Likewise, according to the arterial blood gas results, paO 2 was signifi cantly higher (p < 0.01) in the hypertonic saline group compared to the other groups, and paCO 2 was signifi cantly lower (p < 0.01). CRP, TNF-α and IL-6 levels of infl ammatory markers were also signifi cantly lower in hypertonic saline groups compared to other groups (p < 0.001). CONCLUSIONS: Our study shows that treatment with hypertonic saline reduces the progression of ARDS in sepsis (Tab.

Characteristics of New Oxygen-Carrying Plasma and Its Application Prospects in the Treatment of Severe Acute Pancreatitis

“…After ischemia, the intestinal tract releases pro-inflammatory molecules, such as superoxide anion free radicals and cytokines, causing the intestinal flora to shift and enter the portal vein and systemic circulatory system, leading to intestinal remote organ failure 41,42 . A study has shown that HES-130 infusion inhibits the release of pro-inflammatory cytokines, such as tumor necrosis factor α and interleukin 6, 43 which may be the reason for the improvement in intestinal barrier dysfunction 44–46 . Our new type of oxygen-carrying plasma can be used for the treatment of severe acute pancreatitis through the mechanism of HES by improving intestinal oxygen metabolism, reducing the release of inflammatory mediators, and protecting the integrity of the intestinal barrier.…”

“…41,42 A study has shown that HES-130 infusion inhibits the release of pro-inflammatory cytokines, such as tumor necrosis factor α and interleukin 6, 43 which may be the reason for the improvement in intestinal barrier dysfunction. [44][45][46] Our new type of oxygen-carrying plasma can be used for the treatment of severe acute pancreatitis through the mechanism of HES by improving intestinal oxygen metabolism, reducing the release of inflammatory mediators, and protecting the integrity of the intestinal barrier. Reducing the body's oxidative stress and inflammation while reducing the translocation of intestinal bacteria, combined with PolyHb, can increase the oxygen supply of the intestinal mucosa and other important organs and its synergistic effect in improving the mesenteric microcirculation.…”

Immunopharmacological Activities of Luteolin in Chronic Diseases

“…Luteolin administration decreased the expression of TNF-α and IL-10 mRNA in lung tissue. Moreover, luteolin was shown to attenuate sepsis-induced acute lung injury in mice by inhibiting intercellular adhesion molecule (ICAM)-1, NF-κB, oxidative stress, and part of the iNOS pathway [54,55]. Luteolin could be an effective candidate to treat HgCl 2 -induced lung injury by blocking NF-κB activation and activating the AKT/Nrf2 pathway.…”

The renoprotective effect of Tibolone in sepsis-induced acute kidney injury

“…Sepsis is a pathological condition characterized by the host's dysregulated inflammatory response to an infection 1,2 . This dysregulation manifests as an imbalance between proinflammatory and anti-inflammatory factors, resulting in tissue damage and the subsequent development of multiple organ dysfunction and failure [3][4][5] . Sepsis continues to be the primary contributor to morbidity and mortality in intensive care units (ICUs) globally 6,7 .…”