Effect of flunixin meglumine alone and in combination on haemodynamics during bovine endotoxic shock and after treatment

Singh, Digvijay; Bansal, Satish Kumar; Ghumman, Gurbrinderjit Singh

doi:10.4236/jbise.2011.41004

Cited by 4 publications

(4 citation statements)

References 4 publications

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“…The values of blood pressure in buffalo heifers are in agreements with the value for BP reported by Singh et al [28,29]. Similar to present results, Whittow [30] reported significantly lower mean blood pressure, in the hot dry environment than they were at 15° C. The increase in systemic arterial blood pressure during summer was attributed to the concomitant increase in cardiac output because the total peripheral resistance diminished.…”

Section: Blood Pressuresupporting

confidence: 92%

Physiological Changes and Blood Flow in Murrah Buffaloes during Summer and Winter Season

Upadhyay

Kumar

et al. 2014

J Buf Sci

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Present study was designed to investigate the changes in physiological reactions and blood flow during different seasons in Murrah buffaloes. Six Murrah buffalo heifers of 18-24 months were selected as experimental animals. The respiration rate (RR), heart rate (HR) and blood pressure was measured through BPL-Excello multi parameter monitor. Rectal temperatures were recorded with electronic thermometer. Skin surface temperatures at the different body sites were recorded using infrared thermometer (Metravi MT-2). The blood flow was measured on Perimed Multichannel Laser Doppler system using skin perfusion probe 408 at dorsal region, abdomen region and middle ear. Results showed a significant difference for respiration rate (P<0.001); rectal temperature (P<0.05) and heart rate (P<0.001) during summer and winter season. The mean blood pressure was 93.74/186.36 mmHg in summer and 97.40/198.08 mmHg in winter, respectively. In the present experiment, both diastolic and systolic pressure differed significantly (P<0.001) during different seasons. The mean skin surface temperature in summer was 37.03±0.39, 36.12±0.27 and 33.15±0.98°C at dorsal, abdomen and middle ear, respectively; whereas, during winter it was 29.87±0.69, 29.92±0.40 and 23.82±1.12°C at dorsal, abdomen and middle ear, respectively. The skin surface temperature among the different parts of the body differed significantly (P<0.001). During summer, the mean blood flow was 4.71±0.49, 14.85±1.63 and 16.72±1.47 PU; whereas, during winter, it was low, 1.10±0.16, 8.96±0.58 and 12.16±0.95 PU at dorsal, abdomen and middle ear, respectively. The difference in the blood flow among the different parts of the body differed significantly (P<0.001) in summer and winter. The results indicated that blood flow was positively correlated with temperature of the body parts and it varied in different seasons. This study concluded that, summer stress evokes a series of physiological changes in the Murrah buffalo's, which affects production during summer season.

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Section: Blood Pressuresupporting

confidence: 92%

Physiological Changes and Blood Flow in Murrah Buffaloes during Summer and Winter Season

Upadhyay

Kumar

et al. 2014

J Buf Sci

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“…In the current research, the calves in LPS-treated groups showed some of the clinical and physiological signs of endotoxemia ( Table 1 ). Previous studies have shown that intravenous injection of E. coli toxin in calves leads to changes in sucking reflex, capillary refilling time, body temperature, respiration rate, and heart rate [ 23 , 43 ]. In our current study, a combination therapy initiated 2 hr after LPS injection prevented frequent defecation, and decreased the adverse effects of endotoxemia on capillary refilling time, sucking reflex and general health indicators.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of ceftiofur in healthy and lipopolysaccharide-induced endotoxemic newborn calves treated with single and combined therapy

Altan

Üney

et al. 2017

The Journal of Veterinary Medical Science

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The aim of this research was to compare plasma pharmacokinetics of ceftiofur sodium (CS) in healthy calves, and in calves with experimentally induced endotoxemia. Six calves received CS (2.2 mg/kg, IM) 2 hr after intravenous administration of 0.9% NaCl (Ceft group). After a washout period, the same 6 calves received CS 2 hr after intravenous injection of lipopolysaccharide (LPS+Ceft group). Another group of 6 calves received a combination of drug therapies that included CS 2 hr after administration of 0.9% NaCl (Comb group). A third group of 6 calves received the same combination therapy regimen 2 hr after intravenous injection of lipopolysaccharide (LPS+Comb group). Plasma concentrations of CS and all desfuroylceftiofur-related metabolites were determined using HPLC, and its pharmacokinetic properties were determined based on a two-compartment model. The peak concentration of CS in the LPS+Comb group occurred the earliest, and the clearance rate of CS was the highest in the Comb and LPS+Comb groups (P<0.05). The elimination half-life of CS in the LPS+Ceft group was longer than that in the Ceft and Comb groups (P<0.05). The results of this study indicate that combined therapies and endotoxemic status may alter the plasma pharmacokinetics of CS in calves.

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“…The fall in MAP during endotoxin infusion (non-significant during the present study) may be due to the release of prostaglandins (Margolis et al, 1987). The rise in MAP might be due to the fact that flunixin meglumine, one of the important components of the treatment, is a cyclo oxygenase inhibitor and prevents the formation of prostaglandin and hence improves tissue perfusion (Singh et al, 2011). Another reason could be that HSS infusion increases the plasma osmolality and osmotically draws intracellular and interstitial water into vascular system.…”

Section: Cardiovascular Haemodynamicmentioning

confidence: 57%

“…The mean body temperature in all the animals showed non-significant alterations during endotoxin infusion and after treatment with Flunixin meglumine, HSS, Dextran-40 and Blood (Table 1). Similarly, Singh et al, (2011) observed non-significant decrease in body temperature during endotoxin infusion and after treatment with NSAIDS.…”

Section: Hematologymentioning

confidence: 85%

Hemodynamic and blood biochemical profile during endotoxemia and after therapeutic intervention in buffalo calves.

Singh¹,

Singh²

2017

Int. J. Curr. Res. Biol. Med

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Five apparently healthy male buffalo calves aged between 6-12 months were infused with Escherichia coli endotoxin @5μg/kg BW/hr for 3 hours to induce the symptoms of endotoxemia like corneal opacity, increased respiration rate, hypoproteinemia, hypoalbuminemia, hypoglycemia, decrease in mean systolic, diastolic, pulse and mean arterial and central venous pressure along with inconsistent changes in heart rate in the present investigation. The endotoxemic animals were then treated with hypertonic saline solution (HSS) @ 4 ml/Kg BW, Dextran-40 @ 10 ml/Kg BW, Flunixin Meglumine 1.1 mg/Kg BW and blood @ 20 ml/Kg BW as a single infusion which raised the systolic, diastolic, pulse, mean arterial and central venous pressure along with hematocrit and hemoglobin to the levels either close or even higher than the normal pre-infusion levels. Respiration rate and body temperature showed non-significant alterations during endotoxin infusion and after therapeutic intervention. A non-significant increase in total protein was observed after treatment which reached close to pre-infusion level. Mean plasma fibrinogen showed non-significant rise throughout the period of observation while plasma albumin, globulin and creatinine varied non-significantly. A significant increase was seen in plasma glucose level at 5th, 6th and 7th hour as compared to pre-infusion normal values. Overall, treatment given to the animals was found to be effective.

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Effect of flunixin meglumine alone and in combination on haemodynamics during bovine endotoxic shock and after treatment

Cited by 4 publications

References 4 publications

Physiological Changes and Blood Flow in Murrah Buffaloes during Summer and Winter Season

Physiological Changes and Blood Flow in Murrah Buffaloes during Summer and Winter Season

Pharmacokinetics of ceftiofur in healthy and lipopolysaccharide-induced endotoxemic newborn calves treated with single and combined therapy

Hemodynamic and blood biochemical profile during endotoxemia and after therapeutic intervention in buffalo calves.

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