Effect of Fluoride and Glycyrrhizin Mouthrinses on Artificial Caries Lesions in vivo (Short Communication)

Deutchman, Mark; Petrou, I.D.; Mellberg, J.R.

doi:10.1159/000261179

Cited by 9 publications

(3 citation statements)

References 5 publications

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“…Interestingly, Gedalia et al (1986) reported that glycyrrhizin, when added to an acidulated phosphate‐fluoride solution, increases fluoride uptake and reduces enamel solubility most likely due to a surface‐coating effect and to its deposition in the porous structure of demineralized enamel. In contrast, Deutchman et al (1989) did not observe any significant effect with glycyrrhizin in regard to mineral loss in an artificial caries lesions in vivo model. This may have been related to insufficient glycyrrhizin concentration or exposure time.…”

Section: Dental Caries and Licoricecontrasting

confidence: 69%

Licorice and its potential beneficial effects in common oro‐dental diseases

et al. 2011

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Licorice, the name given to the roots and stolons of Glycyrrhiza species, has been used since ancient times as a traditional herbal remedy. Licorice contains several classes of secondary metabolites with which numerous human health benefits have been associated. Recent research suggests that licorice and its bioactive ingredients such as glycyrrhizin, glabridin, licochalcone A, licoricidin, and licorisoflavan A possess potential beneficial effects in oral diseases. This paper reviews the effects of licorice and licorice constituents on both the oral microbial pathogens and the host immune response involved in common ora-dental diseases (dental caries, periodontitis, candidiasis, and recurrent aphthous ulcers). It also summarizes results of clinical trials that investigated the potential beneficial effects of licorice and its constituents for preventing/treating oro-dental diseases.

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Section: Dental Caries and Licoricecontrasting

confidence: 69%

Licorice and its potential beneficial effects in common oro‐dental diseases

et al. 2011

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“…The extent ofthe mineral loss in the placebo group was larger than usual for this in situ model, but is not unprecedented. For example, the placebo groups in two mouthrinse studies resulted in 70.2% and 99.5% demineralization (Mellberget al, 1988;Deutchman et al, 1989). This large mineral loss shows that the average caries challenge in the subjects during the test periods was very great.…”

Section: Resultsmentioning

confidence: 99%

Remineralization and Demineralization in situ from a Triclosan/Co-polymer/Fluoride Dentifrice

et al. 1991

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An in situ study was conducted to evaluate the effect of a dentifrice containing 1100 ppm F (NaF) and triclosan, an anti-plaque agent, on remineralization of artificially-formed caries lesions in thin sections of human enamel. The thin sections were placed in mandibular partial dentures of 15 subjects and covered with a steel mesh to provide an area for plaque accumulation. The subjects brushed their teeth and dentures three times daily for two-week periods in a cross-over design, after which the specimens were removed and analyzed by quantitative microradiography for changes in mineral content. Results showed that lesions treated with the triclosan-fluoride product were remineralized 18.0 +/- 23.4% compared with 19.0 +/- 32.3% from a 1100-ppm F (NaF) positive control. Use of a placebo dentifrice resulted in 71.9% demineralization. The findings showed that triclosan neither enhanced nor interfered with the promotion of remineralization by fluoride.

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“…The first property investigated was the antiadherent property of glycyrrhizin that inhibits the glucosyltransferase activity of Streptococcus mutans, which is required for biofilm formation [30]. Several studies have investigated the surface coating effect of glycyrrhizin, but conflicting results have been reported [31][32][33]. Other studies have used licorice as an ingredient in oral hygiene products [34], but additional clinical trials are required to confirm its potential effectiveness in controlling dental caries.…”

Section: Dental Cariesmentioning

confidence: 99%

The Power of Licorice (Radix glycyrrhizae) to Improve Oral Health: A Comprehensive Review of Its Pharmacological Properties and Clinical Implications

AlDehlawi,

Jazzar

2023

Healthcare

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Licorice (Radix glycyrrhizae) is a plant root extract widely used in various applications, including cosmetics, food supplements, and traditional medicine. It has a long history of medicinal use in different cultures due to its diverse pharmacological properties. Licorice has traditionally been used for treating gastrointestinal problems, respiratory infections, cough, bronchitis, arthritis, and skin conditions. In recent years, the potential therapeutic benefits of licorice for oral health have gained significant interest. This paper aims to provide a comprehensive review of the effects of licorice extracts and their bioactive components on common oral diseases such as dental caries, periodontitis, halitosis, candidiasis, and recurrent aphthous ulcers. The chemical composition of licorice has shown the presence of several bioactive compounds such as glycyrrhizin, glabridin, isoliquiritigenin (ISL), and licochalcone exhibiting various pharmacological activities, including anti-inflammatory, antimicrobial, antioxidative, and immunomodulatory effects. Interestingly, in certain patients, licorice has shown a promising potential to inhibit the spread of viruses, prevent biofilm formation, reduce inflammation, boost immune responses, alleviate pain, and exert antioxidative effects. In this review, we provide a brief overview of the current understanding of licorice’s therapeutic benefits in the treatment of oral ailments, emphasising its potential as an alternative treatment option for oral diseases. Further research is warranted to explore its efficacy, safety, and clinical applications using placebo-controlled clinical trials.

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Effect of Fluoride and Glycyrrhizin Mouthrinses on Artificial Caries Lesions in vivo (Short Communication)

Cited by 9 publications

References 5 publications

Licorice and its potential beneficial effects in common oro‐dental diseases

Licorice and its potential beneficial effects in common oro‐dental diseases

Remineralization and Demineralization in situ from a Triclosan/Co-polymer/Fluoride Dentifrice

The Power of Licorice (Radix glycyrrhizae) to Improve Oral Health: A Comprehensive Review of Its Pharmacological Properties and Clinical Implications

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