Effect of fluoride dentifrice and casein phosphopeptide-amorphous calcium phosphate cream with and without fluoride in preventing enamel demineralization in a pH cyclic study

Sinfiteli, Priscila de Pinto; Coutinho, Thereza Christina Lopes; Oliveira, Patrícia Regina Almeida de; Vasques, Wesley F.; Azevedo, Leandra Matos; Pereira, António; Tostes, Mônica Almeida

doi:10.1590/1678-7757-2016-0559

Cited by 18 publications

(18 citation statements)

References 21 publications

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“…In this regard, the GC Tooth Mousse group showed the highest calcium content among other groups. Our results were also in accordance with those of the studies performed by Chaudhary et al, (16) Chokshi et al, (28) and Sinfiteli et al (29) The proposed mechanism of action of CPP-ACP products describes that these products act as a calcium-phosphate reservoir, buffering the activities of free calcium and phosphate ions in the plaque fluid, helping to preserve a state of supersaturation of enamel, inhibiting demineralization and promoting remineralization. (12,16) Lata et al studied the remineralization potential of fluoride and CPP-ACP in enamel lesions and reported that fluoride was more effective in remineralization although CPP-ACP had the ability to reinforce the enamel.…”

Section: Discussionsupporting

confidence: 93%

An in-vitro Comparison of Calcium Uptake by Intact Enamel after Using two Types of Casein Phosphopeptide-Amorphous Calcium Phosphate Paste

Hekmatfar¹,

Jafari²,

Mohammadpour³

2018

J Res Dentomaxillofac Sci

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Background and Aim: Dental caries is one of the most common childhood diseases worldwide. The implementation of strategies that facilitate the prevention of early dental caries and interrupt its progression has been recently advocated. It has been reported that casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) derived from casein reduces tooth demineralization and enhances the remineralization process. The aim of this in-vitro study was to assess the efficacy of two types of CPP-ACP paste in calcium uptake by enamel surfaces. Materials and methods: Forty premolars were longitudinally dissected into experimental and control halves, and were coated with nail varnish, except for an enamel window of 4×4 mm. The samples were subjected to cycling in a demineralizing solution and were divided into two groups of GC Tooth Mousse CPP-ACP paste and Misswake CPP-ACP paste. The calcium contents of each half were examined using the acid etch enamel biopsy technique and were measured by atomic absorption. The values were statistically analyzed using Kolmogorov-Smirnov test and one-way analysis of variance (ANOVA). Results: The enamel surfaces treated with the pastes exhibited higher calcium contents compared to the controls. There was a significant difference between GC Tooth Mousse CPP-ACP paste and Misswake CPP-ACP paste in terms of calcium uptake; a higher calcium uptake was witnessed with GC Tooth Mousse CPP-ACP paste than with Misswake CPP-ACP paste (P<0.05). Conclusion: Misswake CPP-ACP paste presented some protective potentials; however, the samples treated with GC Tooth Mousse CPP-ACP paste were better able to uptake calcium. These pastes could be considered as effective means for the prevention of dental caries in susceptible patients.

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Section: Discussionsupporting

confidence: 93%

An in-vitro Comparison of Calcium Uptake by Intact Enamel after Using two Types of Casein Phosphopeptide-Amorphous Calcium Phosphate Paste

Hekmatfar¹,

Jafari²,

Mohammadpour³

2018

J Res Dentomaxillofac Sci

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“…The remineralizing potential of CPP-ACP and CPP-ACPF as observed in the current study has also been observed in other in vitro studies, 11 , 25 , 29 in situ studies, 15 , 30 and in vivo studies 31 32 However, Pulido and coworkers 26 (2008) observed no significant differences between the effects of CPP-ACPF and artificial saliva on the inhibition of a lesion progression in an in vitro setting.…”

Section: Discussionsupporting

confidence: 87%

The in vitro remineralizing effect of CPP-ACP and CPP-ACPF after 6 and 12 weeks on initial caries lesion

Thierens¹,

Moerman²,

Elst³

et al. 2019

J. Appl. Oral Sci.

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Objective: The aim of this in vitro study was to determine the effects of remineralization promoting agents containing casein phosphopeptide-stabilized amorphous calcium phosphate (CPP-ACP), or CPP-ACP in combination with fluoride (CPP-ACPF) on artificial white spot lesions (WSLs) after 6 and 12 weeks. Methodology: White spot lesions were created on 123 sectioned premolars (246 specimens) with a demineralization solution during a 96 hours pH-cycling regime. Two experimental groups were created: a CPP-ACP group (Tooth Mousse™), and a CPP-ACPF group (Mi Paste Plus™). Additionally, two control groups were created, one using only a conventional toothpaste (1450 ppm fluoride) and another one without any working agents. All teeth were also daily brushed with the conventional toothpaste except the second control group. Tooth Mousse™ and Mi Paste Plus™ were applied for 180 seconds every day. The volume of demineralization was measured with transverse microradiography. Six lesion characteristics regarding the lesion depth and mineral content of WSLs were also determined. Results: The application of CPP-ACP and CPP-ACPF had a significant regenerative effect on the WSLs. Compared to Control group 1 and 2 the volume of demineralization after 6 weeks decreased significantly for CPP-ACP (respectively p <0.001 and p <0.001) and CPP-ACPF (respectively p =0.001 and p =0.003). The same trend was observed after 12 weeks. For the CPP-ACPF group, WSL dimensions decreased significantly between 6 and 12 weeks follow-up ( p =0.012). The lesion depth reduced significantly after application of CPP-ACP and CPP-ACPF but increased significantly in the Control groups. Mineral content increased for CPP-ACP and CPP-ACPF after an application period of 12 weeks, but this was only significant for CPP-ACP. Conclusions: Long-term use of CPP-ACP and CPP-ACPF in combination with a conventional tooth paste shows beneficial effects in the recovery of in vitro subsurface caries lesions.

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“…Studies have been conducted on the efficacy of toothpastes and topical creams containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) with fluoride in preventing erosive tooth wear from acidic beverages or solutions [32] , [33] , [34] . A randomized controlled trial was conducted by Maden et al [32] to investigate the effect of acidulated phosphate F (APF) gel and CPP-ACP on the dental erosion in primary teeth.…”

Section: Classification Of Pmfs In Dentistrymentioning

confidence: 99%

Polymeric materials and films in dentistry: An overview

Rokaya

Srimaneepong

Sapkota

et al. 2018

Journal of Advanced Research

166

116

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Effect of fluoride dentifrice and casein phosphopeptide-amorphous calcium phosphate cream with and without fluoride in preventing enamel demineralization in a pH cyclic study

Cited by 18 publications

References 21 publications

An in-vitro Comparison of Calcium Uptake by Intact Enamel after Using two Types of Casein Phosphopeptide-Amorphous Calcium Phosphate Paste

An in-vitro Comparison of Calcium Uptake by Intact Enamel after Using two Types of Casein Phosphopeptide-Amorphous Calcium Phosphate Paste

The in vitro remineralizing effect of CPP-ACP and CPP-ACPF after 6 and 12 weeks on initial caries lesion

Polymeric materials and films in dentistry: An overview

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