Effect of Fluoxetine on the Hippocampus of Wistar Albino Rats in Cold Restraint Stress Model

Jayakumar, S.; Raghunath, Gunapriya; Ilango, Saraswathi; Vijayakumar, J; Vijayaraghavan, R.

doi:10.7860/jcdr/2017/26958.9953

Cited by 17 publications

(14 citation statements)

References 44 publications

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“…As expected, the effect of oleuropein, on GSH and TBARS, was superior to that of fluoxetine. Fluoxetine ameliorated Cort-induced lipid peroxidation and GSH depletion, and this was in accordance with Jayakumar et al, and Rebai et al 54,55 . The antioxidant activity of oleuropein was previously reported in various tissues 56,57 and in the brain 58,59 .…”

Section: Discussionsupporting

confidence: 89%

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Oleuropein Reverses Repeated Corticosterone-Induced Depressive-Like Behavior in mice: Evidence of Modulating Effect on Biogenic Amines

Badr

Attia

Al-Rasheed

2020

Sci Rep

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Depression is still one of challenging, and widely encountered disorders with complex etiology. The role of healthy diet and olive oil in ameliorating depression has been claimed. This study was designed to explore the effects of oleuropein; the main constituent of olive oil; on depression-like behaviors that are induced by repeated administration of corticosterone (40 mg/kg, i.p.), once a day for 21 days, in mice. Oleuropein (8, 16, and 32 mg/kg, i.p.) or fluoxetine (20 mg/kg, positive control, i.p.1) was administered 30 minutes prior to corticosterone injection. Sucrose consumption test, open-field test (OFT), tail suspension test (TST), and forced swimming test (FST) were performed. Reduced Glutathione (GSH), lipid peroxidation, and biogenic amines; serotonin, dopamine, and nor-epinephrine; levels were also analyzed in brain homogenates. Corticosterone treatment induced depression-like behaviors, it increased immobility time in the TST, OFT, and FST, decreased the number of movements in OFT, and decreased sucrose consumption. Corticosterone effect was associated with depletion of reduced glutathione and increase of lipid peroxidation, in addition to modification of biogenic amines; decreased serotonin and dopamine. Oleuropein or fluoxetine administration counteracted corticosterone-induced changes. In conclusion, oleuropein showed a promising antidepressant activity, that is evident by improving corticosterone-induced depression-like behaviors, and normalizing levels of biogenic amines.

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Section: Discussionsupporting

confidence: 89%

“…The three main brain monoamines (noradrenaline, 5-HT and dopamine) regulate several behavioral functions and play critical role in learning, sleep, mood, anxiety, motor coordination, and learning 54 . An association between their deficiency and the pathogenesis of depression and its symptoms has been suggested 62 .…”

Section: Discussionmentioning

confidence: 99%

Oleuropein Reverses Repeated Corticosterone-Induced Depressive-Like Behavior in mice: Evidence of Modulating Effect on Biogenic Amines

Badr

Attia

Al-Rasheed

2020

Sci Rep

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“…Results of our study showed that the level of serum CORT was significantly increased in acute CRS group as compared to either control or omega‐3 group which is compatible with Jayakumar, Raghunath, Ilango, Vijayakumar, and Vijayaraghavan () who reported that exposure of animals to CRS led to upregulation of stress hormones by hyper activation of HPA axis which can also alter antioxidant system.…”

Section: Discussionsupporting

confidence: 89%

Preventive effect of omega‐3 fatty acids in a rat model of stress‐induced liver injury

Ali

Rifaai

2018

Journal Cellular Physiology

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Omega‐3 fatty acids are gaining attention as a therapeutic agent of many diseases. Their protective effect in a variety of diseases has been demonstrated. To the best of our knowledge, this is the first study on omega‐3 fatty acids related to acute cold‐restraint stress (CRS) induced hepatic dysfunction in rats. Forty adult male Sprague–Dawley albino rats were used and classified into: control, omega‐3 group, each rat was pretreated with omega‐3 fatty acids; CRS group, rats were subjected to acute CRS for 6 hr; and CRS group pretreated with omega‐3 fatty acids. Serum was obtained to determine corticosterone (CORT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and tumor necrosis factor‐α (TNF‐α) levels. Hepatic malondialdehyde (MDA) and total antioxidant capacity (TAC) levels were measured. Also, liver tissues were taken for histological examination and immunohistochemical assessment of the apoptotic marker, caspase‐3. Results showed that pretreatment of stressed rats with omega‐3 fatty acids led to significant decrease in hepatic MDA and increase in TAC levels. They reduced serum levels of CORT, ALT, AST, and TNF‐α. Also, they improved liver damage and suppressed hepatic caspase‐3 expression. In conclusion, pretreatment of stressed rats with omega‐3 fatty acids has ameliorated stress‐induced liver damage due to their antioxidant, anti‐inflammatory, and antiapoptotic effects. So, they can be used to minimize stress complications on the liver.

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“…The increased 5-HT and dopamine levels could be the result of the deleterious activities of noise on the hippocampus (Jayakumar, 2017).…”

Section: Resultsmentioning

confidence: 99%

Neuroprotective potential of Costus speciosus on neurotransmitters levels in noise stress condition in rats

Ilango¹,

Saikumar²,

Kandhaswamy³

et al. 2020

ijrps

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Exposure to overwhelming stress could lead to development of mental disorders and worsening of existing ones. The impact produced by exposure to stress might be affected by the seriousness of the stressor, the time amid which it is connected (acute vs. chronic). In traditional practice of medicine, C. speciosus extract exhibits antistress action so we aimed to test whether this extract plays a vital role in maintaining the brain's chemical transmitters levels during acute noise stress conditions. The levels of Dopamine (DA), Norepinephrine (NE) and Serotonin (5HT) were analysed by reverse phase HPLC in cerebral cortex and hippocampus brain tissue of acute noise stress exposed, C. speciosus extract (250mg and 500mg) and fluoxetine treated rats. Norepinephrine and dopamine were found to be increased in contrast to 5-HT levels in stressed group of rats, whereas CSE 500 mg could alleviate the said alteration. This study highlights the importance of C. speciosus extract therapy to noise stress induced rats by testing the neurotransmitters levels in brain tissue to understand its therapeutic potential.

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Effect of Fluoxetine on the Hippocampus of Wistar Albino Rats in Cold Restraint Stress Model

Cited by 17 publications

References 44 publications

Oleuropein Reverses Repeated Corticosterone-Induced Depressive-Like Behavior in mice: Evidence of Modulating Effect on Biogenic Amines

Oleuropein Reverses Repeated Corticosterone-Induced Depressive-Like Behavior in mice: Evidence of Modulating Effect on Biogenic Amines

Preventive effect of omega‐3 fatty acids in a rat model of stress‐induced liver injury

Neuroprotective potential of Costus speciosus on neurotransmitters levels in noise stress condition in rats

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