Effect of fluticasone on growth in children with asthma

Whitaker, Katharine; Webb, J.; Barnes, Joanna; Barnes, N.

doi:10.1016/s0140-6736(05)64394-2

Cited by 20 publications

(10 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The study by WHITAKER et al [8] also confirms the 2:1 potency ratio of FP compared with BDP and budesonide and indicates that at therapeutically equivalent doses, if substituted for BDP or budesonide, FP may allow catch-up growth to occur in children with suppressed growth. At higher than currently recommended doses, bearing in mind the need for only half the daily milligram dose of FP compared with other inhaled steroids, there is no reason to expect otherwise.…”

Section: From the Authorsmentioning

confidence: 81%

See 1 more Smart Citation

Side-effects of high-dose fluticasone propionate in children

Todd¹

1999

Eur Respir J

View full text Add to dashboard Cite

Section: From the Authorsmentioning

confidence: 81%

“…day -1 for 1 yr, during which asthma control was well maintained, their mean height velocity standard deviation scores increased substantially (i.e. from -1.7 on BDP and -1.0 on budesonide, to +1.6 on FP) [8].…”

Section: From the Authorsmentioning

confidence: 98%

Side-effects of high-dose fluticasone propionate in children

Todd¹

1999

Eur Respir J

View full text Add to dashboard Cite

“…Unfortunately this 4-yr study did not specify the use of stadiometry to measure height, and no results for specific inhaled corticosteroids were presented. In a primary carebased study, children receiving inhaled budesonide or beclomethasone dipropionate for a year were found to have low growth velocity (SDS scores of -1.0 and -1.7 respectively) [38]. However, switching the 20 children with slowest growth to fluticasone propionate treatment for 1 yr resulted in an increase in growth velocity SDS to z1.6.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the effects of asthma therapy on childhood growth: what can be learnt from the published literature?

Price

Hindmarsh²,

Hughes³

et al. 2002

Eur Respir J

View full text Add to dashboard Cite

Evaluating the effects of asthma therapy on childhood growth: what can be learnt from the published literature? J. Price, P. Hindmarsh, S. Hughes, J. Efthimiou. #ERS Journals Ltd 2002. ABSTRACT: The difficulties of assessing the effects of asthma therapy on childhood growth were explored in the first part of this review. In this part of the review growth studies with inhaled corticosteroids were selected that included a control group, measured height by stadiometry and were of o1 yr duration. The studies were classified as type 1 (placebo control), type 2 (nonsteroidal therapy control), type 3 (comparator inhaled corticosteroid control) or type 4 ("real-life" studies with dose adjustment). The design attributes of these studies were then compared with the recommendations described in the first part of this review. Of the 18 studies identified, 17 were susceptible to one or more important confounding factors. Nevertheless, the outcomes of all 18 studies were mostly consistent.At recommended doses, beclomethasone dipropionate and budesonide demonstrated a small degree of growth suppression over 1-2 yrs (study types 1 and 2), but there was little evidence of such an effect with fluticasone propionate. Studies comparing different inhaled corticosteroids at recommended doses indicated more rapid growth with fluticasone propionate than with beclomethasone dipropionate or budesonide. However, none of the inhaled corticosteroids appeared to affect final height.In conclusion, the results from the majority of published growth studies with inhaled corticosteroids must be interpreted with a degree of caution owing to their potential susceptibility to important confounding factors. Further well-designed studies are needed to establish whether different inhaled corticosteroids have different effects on growth in the long term.

show abstract

“…Both groups had normal growth velocities but lung function was better in those receiving fluticasone. Whitaker et al ,19 in a study based in general practice, showed significant reductions in growth velocity of 66 prepubertal children receiving beclomethasone or budesonide in doses of 200 to 400 μg daily given as dry powder inhalers. Twenty of the children with the lowest growth velocities showed catch up growth when changed to fluticasone in equipotent doses.…”

Section: Inhaled Corticosteroidsmentioning

confidence: 99%