Effect of follicle-stimulating hormone (FSH) on radiation-induced chromosomal aberrations in mouse germ cells and Chinese hamster cells in vitro

Buul, Paul P.W. van; Goudzwaard, Johan H.

doi:10.1016/0027-5107(82)90106-3

Cited by 6 publications

(1 citation statement)

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“…Progesterones also have similar effects, causing excess chromosomal gaps and breaks (16), and a synergistic effect was seen among progesterone, estrogen, and human chorionic gonadotrophin. Both prolactin and follicle-stimulating hormone produce excess chromosomal gaps and breaks (17,18) These reports clearly demonstrate that a variety of female hormones may play a role in modifying or enhancing DNA damage. Figure 3 demonstrates that as the level of progesterone increased in this female volunteer, so the chromosomal aberration level also rose.…”

Section: Resultsmentioning

confidence: 82%

Effect of Hormones on the Variation of Radiosensitivity in Females as Measured by Induction of Chromosomal Aberrations

Roberts¹,

Morgan²,

Danford³

1997

Environmental Health Perspectives

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The frequency of dicentrics + ring (dic/cell) and total chromosome aberrations (dicentrics, rings and excess acentrics, etc.) per cell (TAb/cell) has been studied in 50 male and female volunteers after high or low dose rate (HDR, LDR) irradiation of peripheral blood lymphocytes. The mean male aberration frequencies per cell after HDR irradiation were 0.38 dic/cell and 0.61 TAb/cell; following LDR irradiation, the mean aberration frequencies were 0.28 dic/cell and 0.45 TAb/cell. Equivalent female values after HDR irradiation were 0.42 dic/cell and 0.71 TAb/cell; after LDR irradiation, the mean aberration frequencies were 0.30 dic/cell and 0.48 TAb/cell. Analysis of variance showed that there was a highly significant difference between males and females after HDR, but not LDR, irradiation. It is concluded from this study that females have a greater variability in their radioresponse, and that this variability is related to progesterone, which has a profound effect upon radiosensitivity, as measured by cytogenetic end points.

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Section: Resultsmentioning

confidence: 82%