Effect of food intake and ambient air pollution exposure on ankylosing spondylitis disease activity

Soleimanifar, Narjes; Nicknam, Mohammad Hossein; Bidad, Katayoon; Jamshidi, Ahmad Reza; Mahmoudi, Mahdi; Mostafaei, Shayan; Hosseini‐Khah, Zahra; Nikbin, Behrouz

doi:10.1186/s42358-019-0051-2

Cited by 25 publications

(12 citation statements)

References 27 publications

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“…Mitigating the pollutant factor could save the Spanish State 350 million (M) euros, as well as undoubtedly reducing the suffering caused by this type of disease. In Ankylosing Spondylitis (AS), a >60% correlation with pollutant particles (PM 2.5 ) has been found: a prolonged exposure leads to worsening in the control of the inflammatory outbreak of this disease [ 109 ]. An average cost to address AS in Spain of 11,462 euros/patient/year has been estimated, including direct costs and productivity losses [ 110 ].…”

Section: Resultsmentioning

confidence: 99%

Impact of Climate Change on Eye Diseases and Associated Economical Costs

Echevarría-Lucas¹,

Senciales-González

Medialdea-Hurtado³

et al. 2021

IJERPH

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Climate change generates negative impacts on human health. However, little is known about specific impacts on eye diseases, especially in arid and semi-arid areas where increases in air temperatures are expected. Therefore, the main goals of this research are: (i) to highlight the association between common eye diseases and environmental factors; and (ii) to analyze, through the available literature, the health expenditure involved in combating these diseases and the savings from mitigating the environmental factors that aggravate them. Mixed methods were used to assess the cross-variables (environmental factors, eye diseases, health costs). Considering Southern Spain as an example, our results showed that areas with similar climatic conditions could increase eye diseases due to a sustained increase in temperatures and torrential rains, among other factors. We highlight that an increase in eye diseases in Southern Spain is conditioned by the effects of climate change by up to 36.5%; the economic burden of the main eye diseases, extrapolated to the rest of the country, would represent an annual burden of 0.7% of Spain’s Gross Domestic Product. In conclusion, the increase in eye diseases has a strong economic and social impact that could be reduced with proper management of the effects of climate change. We propose a new concept: disease sink, defined as any climate change mitigation action which reduces the incidence or morbidity of disease.

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Section: Resultsmentioning

confidence: 99%

Impact of Climate Change on Eye Diseases and Associated Economical Costs

Echevarría-Lucas¹,

Senciales-González

Medialdea-Hurtado³

et al. 2021

IJERPH

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“…Long-term exposure to PM2.5 is closely related to the BASMI, BASFI, and BASDAI scores of patients with AS. Furthermore Long-term exposure to pollution can cause severe symptoms in patients with AS [ 79 ]. Therefore, more in-depth research is needed to explore the pathogenesis of AS in Chinese patients in the future.…”

Section: Discussionmentioning

confidence: 99%

Serum RANKL levels in Chinese patients with ankylosing spondylitis: a meta-analysis

Zhang

Peng

et al. 2021

J Orthop Surg Res

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Objective We aimed to determine the association between serum receptor activator of nuclear factor-kappa B ligand (sRANKL) levels and ankylosing spondylitis (AS) in Chinese patients. Methods The PubMed, Cochrane Library, Embase, Chinese Biomedical Database, Web of Science, China National Knowledge Infrastructure, VIP, and Wan Fang databases were searched for studies conducted before October 1, 2020, without language restrictions. STATA version 12.0 and Revman version 5.3 were used to analyze the data. The standard mean differences (SMDs) and corresponding 95% confidence intervals (95% CIs) were calculated. Results Twelve clinical case–control studies, including 585 patients with AS and 423 healthy controls, were included. The combined SMD for sRANKL suggested that the sRANKL level was significantly higher in Chinese patients with AS than in healthy controls (SMD: 3.27, 95% CI 2.11–4.43, P < 0.00001). Serum RANKL-related factor osteoprotegerin (OPG) levels (SMD: 0.86, 95% CI 0.09–1.64, P < 0.03) were lower in the Chinese patients with AS than in healthy controls, and the RANKL/OPG ratio (SMD = 1.05, 95% CI 0.64–1.46, P < 0.00001) in Chinese patients with AS was approximately the same as that of healthy controls. Subgroup analysis indicated that patients from North and South China had higher sRANKL levels than controls; the sRANKL levels of patients from South China were higher in the subgroup with a Bath Ankylosing Spondylitis Functional Index (BASFI) of > 4 than those of patients in other subgroups. In terms of duration, patients with AS for > 8 years had higher sRANKL levels than health controls. Other subgroup analyses were conducted by region, language, source of control, age, and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). In these subgroups, the sRANKL levels were significantly higher in the patients with AS than in healthy controls. The BASFI and BASDAI were sources of heterogeneity. Conclusions The sRANKL levels are higher in Chinese patients with AS, especially among those from South China. sRANKL levels may be positively correlated with the pathogenesis of AS among Chinese patients.

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“…Conversely, mineral absorption in nonIBD AS patients is less clear. A casecontrol study showed that AS pa tients have a higher calcium intake compared to healthy controls, measured through the semiquantitative food frequency questionnaire [24]. However, subclinical gut inflam mation, affecting half of AS patients [16], may lead to micronutrient deficiency.…”

Section: Atpase -Adenosine Triphosphatase Ca 2+ -Calcium Casr -Calcmentioning

confidence: 99%

Calcium physiology, metabolism and supplementation: a glance at patients with ankylosing spondylitis

Talotta¹,

Rucci²,

Scaglione³

2020

Reumatologia

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The aim of this review is to describe the metabolism of calcium in ankylosing spondylitis compared to physiologic conditions, and to present the current evidence on the benefits and disadvantages of calcium supplementation in these patients. A narrative review of the literature was conducted using the PubMed database and a total of 65 articles were selected. Calcium is involved in many physiopathological processes, including inflammation, bone loss and bone formation, all of which occur in ankylosing spondylitis. Many ankylosing spondylitis patients suffer from concomitant osteopenia or osteoporosis, which represent indications for calcium supplementation. Conversely, there are still concerns about the use of calcium salts for the prevention of bone fragility in non-osteoporotic or non-osteopenic patients. <br /> In these cases, biologic agents may indirectly normalize calcium dysmetabolism by rebalancing the cytokine milieu, in turn associated with bone remodeling. Calcium supplements may be disadvantageous for entheseal calcifications, but so far there are no clear data confirming that such an association exists.

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Effect of food intake and ambient air pollution exposure on ankylosing spondylitis disease activity

Cited by 25 publications

References 27 publications

Impact of Climate Change on Eye Diseases and Associated Economical Costs

Impact of Climate Change on Eye Diseases and Associated Economical Costs

Serum RANKL levels in Chinese patients with ankylosing spondylitis: a meta-analysis

Calcium physiology, metabolism and supplementation: a glance at patients with ankylosing spondylitis

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