Effect of free gossypol on tissue uptake of iron by everted segments of rat duodenum

Toxicological effects of gossypol

“…When iron was injected with gossypol in rats, the animals showed a normal erythrocyte population whereas gossypol alone showed an increase in erythrocytes (Tone and Jensen, 1974). Gossypol reduces the uptake of iron by everted segments of rat duodenum when it is present with the iron simultaneously in the mucosal medium (Herman and Smith, 1975). Absorption of the iron is decreased when bound gossypol is fed to rats .…”