Effect of Frontal and Temporal Seizure Foci on P50 Auditory Evoked Potentials

Sj, Weate; Jl, Moore; Me, Drake

doi:10.1177/155005949502600407

Cited by 12 publications

(8 citation statements)

References 10 publications

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“…2,10 The most consistently reported abnormality of these components is amplitude reduction of the P50 and N100, and less consistently, the P200. 11 Though the P50 has also been reported to decrease in amplitude in epileptic patients, 12,13 the N100 amplitude was reported not to be affected in this population. 2 To our knowledge, the P200 has not been examined in this population.…”

mentioning

confidence: 67%

Mid-Latency Auditory-Evoked Responses and Sensory Gating in Focal Epilepsy: A Preliminary Exploration

Boutros

Trautner²,

Korzyukov³

et al. 2006

JNP

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The relationship between epilepsy and psychosis is not well defined. Sensory gating is a possible endophenotype for psychosis, and has not been fully examined in epileptic patients. The authors examined 29 patients with focal epilepsy who were on antiepileptic medications, and 29 age-matched healthy comparison subjects, using a paired-stimulus (S1-S2) paradigm. P50 and N100 amplitudes or gating did not differ between the groups. The P200 was significantly smaller and did not gate as well in epileptic patients. Though alteration of sensory gating can be demonstrated in epileptic patients, it seems to be qualitatively different from alterations reported in association with schizophrenia.

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confidence: 67%

Mid-Latency Auditory-Evoked Responses and Sensory Gating in Focal Epilepsy: A Preliminary Exploration

Boutros

Trautner²,

Korzyukov³

et al. 2006

JNP

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“…A previous study from our group indicates that epileptogenic processes did not significantly affect P50 gating (Boutros et al, 2006). Similarly, Weate et al (1995) found normal scalp-recorded P50 sensory gating in patients with frontal lobe epilepsy. Nevertheless, we applied in the present study strict patient inclusion criteria with respect to the "normality of EP morphology" in order to minimize possible effects of epilepsy.…”

Section: Brain Generators Of Auditory P50mentioning

confidence: 83%

Generators of the intracranial P50 response in auditory sensory gating

Korzyukov

Pflieger

Wagner³

et al. 2007

NeuroImage

163

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Clarification of the cortical mechanisms underlying auditory sensory gating may advance our understanding of brain dysfunctions associated with schizophrenia. To this end, data from 9 epilepsy patients who participated in an auditory paired-click paradigm during pre-surgical evaluation and had grids of electrodes covering temporal and frontal lobe were analyzed. A distributed source localization approach was applied to intracranial P50 response and Gating Difference Wave obtained by subtracting the response to second stimuli from the response to first stimuli.Source reconstruction of the P50 showed that the main generators of the response were localized at the temporal lobes. The analysis also suggested that the maximum neuronal activity contributing to the amplitude reduction at the P50 time range (phenomenon of auditory sensory gating) is localized at the frontal lobe.Present findings suggest that while the temporal lobe is the main generator of the P50 component, the frontal lobe seems to be a substantial contributor to the process of sensory gating as observed from scalp recordings.

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“…Indirect evidence has been gained by lesion studies indicating an association of deficits in auditory response inhibition with lateral prefrontal cortex (Knight et al, 1999). Studies on patients suffering from temporal lobe epilepsy showed reduced P50 gating; suggesting that anatomical structures mediating P50 gating might be located in temporal structures (Weate et al, 1995). In rat brains, the response of hippocampal pyramidal interneurons, to the second stimulus was found to be almost completely suppressed above all in the CA3 region, indicating that the hippocampus might be an essential mediator of sensory gating (Bickford-Wimer et al, 1990;Freedman et al, 1996).…”

Section: Introductionmentioning

confidence: 98%