Effect of Fucoidan on Anterior Cruciate Ligament Transection and Medial Meniscectomy Induced Osteoarthritis in High-Fat Diet-Induced Obese Rats

Abstract

Osteoarthritis (OA) has become one of the most common disabilities among elders, especially in female. Obesity and mechanical injury causing OA are attributed to joint loading, cartilage disintegration, bone loss and inflammation as well. Several strategies used for treatment OA including non-pharmacological and pharmacological. Fucoidan possesses several bioactivities such as antitumor, antiviral, anticoagulation, anti-obesity, and immunomodulation. This study aims to investigate the effect of fucoidan in surgery-induced OA on diet-induced obesity rats. OA was induced by anterior cruciate ligament transection and partial medial meniscectomy (ACLT+MMx). Male SD rats were fed high-fat diet (HFD) for 4 weeks to induce obesity before ACLT+MMx to induce OA. OA rats were administered with intragastric water or fucoidan in three different concentrations (32 mg/kg, 64 mg/kg, and 320 mg/kg) after the surgeries for 40 days with HFD. We observed that the swelling in knee joint was alleviated and hind paw weight distribution was rectified after feeding fucoidan, with no significant effect on weight gain and feed intake. Fucoidan administration indicated no significant variation on HDL-Cholesterol level, but reduced plasma triglycerides and LDL-Cholesterol level. In addition, weight-bearing tests showed improvement in the fucoidan-treated group. Our results suggested that fucoidan may improve meniscal/ligamentous injury and obesity-induced OA.

Fucoidan Inhibits NLRP3 Inflammasome Activation by Enhancing p62/SQSTM1-Dependent Selective Autophagy to Alleviate Atherosclerosis

“…: SCXK-Beijing-2014-0008, China) to induce carotid atherosclerotic lesion formation. At 12 weeks of age, the mice in the fucoidan group each received an intraperitoneal injection of fucoidan (60 mg kg -1 day -1 ), and the mice in the model group were injected intraperitoneally with physiological saline once per day [28,29]. At 16 weeks of age, all mice were anesthetized using isoflurane and sacrificed by inner canthus artery exsanguination while still anesthetized [30].…”

Evaluation of Chondroprotective Effects of Hyaluronic Acid in a Rat Model of Osteoarthritis

“…Then animals were allowed to move freely in the cage for two weeks thereafter. 9 They were assigned in two (2) groups, control group and treatment group, with eight (8) rats in each group thereafter. Intra articular (IA) drugs were administered in the right knee joint of the rats two weeks after the surgery.…”

Evaluation of Chondroprotective Efficacy of Triamcinolone in Osteoarthritis Induced Rat Model

“…Nonsteroidal antiinflammatory drugs (NSAIDS), corticosteroids, and viscosupplement substances are widely used drug groups in OA treatment. In case of knee and hip joint OA surgical interventions include arthroscopy, osteotomy and joint replacement can be an option for some individuals after the failure of pharmacological treatment [3,4,5] . Triamcinolone is an intermediate acting synthetic glucocorticoid nature of corticosteroid,Half-life of about 18-36 hours with known anti-inflammatory and immunosuppressive properties [6] .…”