Effect of Funalia trogii in heart tissue of rats exposed to deltamethrin

Abstract

electronic) 0250-4685 (printed) 239Effect of Funalia trogii in heart tissue of rats exposed to deltamethrin [Deltametrine maruz kalan sıçanların kalp dokusunda Funalia trogii'nin etkisi] Research Article [Araştırma Makalesi] Türk Biyokimya Dergisi [Turkish Journal of Biochemistry-Turk J Biochem] 2012; 37 (3) ; 239-244. Yayın tarihi 30 Eylül, 2012 © TurkJBiochem.com [ ABSTRACTObjective: Environmental exposure to deltamethrin can cause alterations in structure and function of different organs. F. Trogii, a white-rot fungus, has antioxidative enzymes such as superoxide dismutase, catalase and glutathione reductase. It is hypothesized that there is an antioxidative role of F. trogii resulting in reducing the extent of heart injury as a result of oxidative stress. The aim of this study to investigate the effect of deltamethrin on heart and to evaluate possible protective role of F. trogii in alleviating the detrimental effect of deltamethrin on heart. Materials and Methods: Twenty-one adult albino female Wistar rats were randomly divided into three groups of seven each: group 1 control, group 2 received deltamethrin, group 3 received deltamethrin plus F. trogii extract. Results: The heart rate was increased and amplitude of QRS complex, duration of P wave and QRS complex were decreased due to deltamethrin administration. The superoxide dismutase and catalase activities were decreased, malondialdehyde level was increased in deltamethrin group. Ultrastructurally, dilatation in sarcoplasmic reticulum cisternaes and disorganisation in the myofibrils were observed in the deltamethrin group. In the deltamethrin plus F. trogii extract group, a decreasing lipid peroxidation and an increasing antioxidant enzyme activity, normal heart electrical activity and normal heart muscle structure was observed as similar to control group Conclusion: F. trogii could protect against deltamethrin induced oxidative stress by decreasing lipid peroxidation and increasing superoxide dismutase and catalase activity. The results indicate the protective effect of F. trogii against heart injury and thereby support its traditional use.

Protective Effects of Zinc as Antioxidant Against the Genotoxic Potential of Deltamethrin

“…This finding came in accordance with previous studies which reported that DM significantly decreased the antioxidant defense [9,15,28,29]. Also DM intoxication caused significant increase in NO concentration [ Table-2].…”

“…This result was agreed with [30][31][32]. Possible reasons for reduction of TAC and increases of NO might be the utilization antioxidant enzymes to challenge the prevailing oxidative stress under the influence of free radicals generated from DM and/or inhibition of enzyme synthesis by DM [28,[33][34][35].…”

Antiapoptotic effect of apigenin and vitamin E against deltamethrin induced toxicity in rats

“…The biological effects of repeated exposure at low dose should be considered in animal and human health as deltamethrin affects several body organs. Changes in the cardiac contractility and increased heart rate were recorded in rats received deltamethrin (Yalın et al, 2012). Prenatal exposure to deltamethrin causes persistent changes in learning, motor behavior, muscarinic acetylcholine receptor binding and blood-brain barrier permeability (Johri et al, 2006;Kung et al, 2015).…”

Ischemia–reperfusion induced injury of rat ovary and the possible protective effect of amlodipine: Histological, immunohistochemial and biochemical study

“…As a consecutive result of cell injury, catalase and glutathione (GSH) levels are reduced causing inactivation of various enzymes [13] . Malondialdehyde (MDA) is the basic product of polyunsaturated fatty acid peroxidation and is quite a toxic molecule.…”