Effect of FX Dialysers on Systemic Inflammation and Quality of Life in Chronic Haemodialysis Patients

Abstract

Background: The FX class of haemodialysers features a new class of high-flux polysulfone membrane which has been suggested to induce less inflammation. Methods: This was a randomized, cross-over study performed on 33 haemodialysis patients. Patients were randomized to FX60 or HF80 dialysers for 3 months and then changed to the other dialyser. Interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), and C-reactive protein (CRP) were measured at baseline, and every 3 months. The Kidney Disease Quality of Life Short Form was also administered. Results: The mean of the difference in the IL-6 level between dialysers was 1.4 ± 8.0 pg/ml (95% CI –1.8, 4.5 pg/ml). There was no significant difference in TNF-α (95% CI –0.35, 0.18 pg/ml) or CRP levels (95% CI –2.67, 6.20 mg/l). The quality of social interaction and role limitations caused by physical health problems were significantly higher with the FX60, p = 0.04 and 0.047, respectively. Conclusions: The FX dialysers do not result in a significant difference in the level of systemic inflammation compared to the HF80.

Clinical outcomes for maintenance hemodialysis patients using a high-flux (FX60) dialyzer

“…or more biocompatible dialyzers may attenuate endothelial dysfunction by removing accumulated toxic substances and elicit lower levels of inflammation, which can lead to more favorable endothelial function and a decreased incidence of future CVD. [8][9][10] Technical developments in dialyzer design have improved the efficiency of therapy, particularly regarding large molecule removal, and have improved the reliability and safety of the therapy. Dialysis innovations that have entered routine clinical use, such as hemodiafiltration or high-flux hemodialysis, are demonstrated improved clinical outcomes.…”

Comparison the effect of high flux and low flux dialyzer on quality of life in hemodialysis patients; a clinical trial

“…Boudville et al appraised the impacts of two high flux dialyzers (FX60 and high flux 80) on inflammatory markers and quality of life scores in hemodialysis patients for three months. Results showed that the two dialyzers did not act differently on inflammatory factors, except that FX60 dialyzer raised the scores in social interaction and physical function, but in general could not change the quality of life for the patients (38). Both studies indicate that the type of dialyzers can affect the quality of life domains.…”

Impact of Low- or High-Flux Haemodialysis and Online Haemodiafiltration on Inflammatory Markers and Lipid Profile in Chronic Haemodialysis Patients

“…They found that TNF-α levels increased during the low-flux session, but decreased during the high-flux session and decreased even more during OL-HDF. On the other hand, Boudville et al [19] could not demonstrate a significant difference in serum TNF-α levels compared to baseline values after a 6-month high-flux HD. In the present study there were no differences in equilibrated Kt/V values for urea in low- or high-flux HD and OL-HDF, indicating that the dialysis dose of treatment modes were sufficiently high and as close as possible to each other.…”