Effect of Gallic Acid on Dementia Type of Alzheimer Disease in Rats: Electrophysiological and Histological Studies

Hajipour, Somayeh; Sarkaki, Alireza; Farbood, Yaghoob; Eidi, Akram; Mortazavi, Pejman; Valizadeh, Zohreh

doi:10.15412/j.bcn.03070203

Cited by 57 publications

(46 citation statements)

References 45 publications

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“…Based on the high contents of phenolic compounds such as cyanidin-3-glucoside, gallic acid, and quercetin-3-O-rutinoside in microencapsulated mulberry fruit extract together with the neuroprotection and memory-enhancing effects of the substances just mentioned [ 35 – 39 ], the neuroprotection and memory-enhancing effects of microencapsulated mulberry fruit extract observed in this study might be related to the contents of aforementioned phenolic compounds. However, the modulation effect induced by the interaction effects among various ingredients may also play the roles.…”

Section: Discussionmentioning

confidence: 68%

Neuroprotective and Cognitive‐Enhancing Effects of Microencapsulation of Mulberry Fruit Extract in Animal Model of Menopausal Women with Metabolic Syndrome

Kawvised

Thukham-mee

2017

Oxidative Medicine and Cellular Longevity

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Currently, the neuroprotectant and memory-enhancing agent for menopausal women with metabolic syndrome is required. Based on the advantages of polyphenolics on numerous changes observed in menopause with metabolic syndrome and the encapsulation method, we hypothesized that microencapsulated mulberry fruit extract (MME) could protect brain damage and improve memory impairment in an animal model of menopause with metabolic syndrome. To test this hypothesis, MME at doses of 10, 50, and 250 mg/kg was given to female Wistar rats which were induced experimental menopause with metabolic syndrome by bilateral ovariectomy (OVX) and fed with high-carbohydrate high-fat (HCHF) diet for 8 weeks. Spatial memory together with neuron density, oxidative stress status, acetylcholinesterase, and phosphorylation of Erk in the hippocampus was assessed at the end of the study. It was found that MME decreased memory impairment, oxidative stress status, and AChE activity but increased neuron density and Erk phosphorylation in the hippocampus. Therefore, the neuroprotective and memory-enhancing effects of MME might partly involve the enhanced cholinergic function and Erk phosphorylation but decreased oxidative stress status in hippocampus. Therefore, MME is the potential novel neuroprotectant and memory-enhancing agent for menopause with metabolic syndrome. However, further research especially clinical trial is still necessary.

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Section: Discussionmentioning

confidence: 68%

Neuroprotective and Cognitive‐Enhancing Effects of Microencapsulation of Mulberry Fruit Extract in Animal Model of Menopausal Women with Metabolic Syndrome

Kawvised

Thukham-mee

2017

Oxidative Medicine and Cellular Longevity

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“…Others have shown that the OG metabolite, gallic acid, has anti-oxidant, free radical scavenging, and anti-inflammatory properties (16). Furthermore, gallic acid inhibits amyloid fibril formation (45) and A␤ oligomerization (46), and it suppresses microglial-mediated neuroinflammation in response to ␤-amyloid (47). With regard to FA, the compound inhibits ␤-amyloid aggregation (48) and reduces A␤/␤-amyloid neurotoxicity (49).…”

Section: Combination Therapy Modifies Alzheimer's Disease-like Pathologymentioning

confidence: 99%

Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer's disease

Mori

Naoki

Tan

et al. 2017

Journal of Biological Chemistry

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To date, there is no effective Alzheimer's disease (AD)-modifying therapy. Nonetheless, combination therapy holds promise, and nutraceuticals (natural dietary compounds with therapeutic properties) and their synthetic derivatives are well-tolerated candidates. We tested whether combination therapy with octyl gallate (OG) and ferulic acid (FA) improves cognition and mitigates AD-like pathology in the presenilin-amyloid β-protein precursor (PSAPP) transgenic mouse model of cerebral amyloidosis. One-year-old mice with established β-amyloid plaques received daily doses of OG and FA alone or in combination for 3 months. PSAPP mice receiving combination therapy had statistically significant improved cognitive function OG or FA single treatment on some (but not all) measures. We also observed additional statistically significant reductions in brain parenchymal and cerebral vascular β-amyloid deposits as well as brain amyloid β-protein abundance in OG- plus FA-treated singly-treated PSAPP mice. These effects coincided with enhanced nonamyloidogenic amyloid β-protein precursor (APP) cleavage, increased α-secretase activity, and β-secretase inhibition. We detected elevated expression of nonamyloidogenic soluble APP-α and the α-secretase candidate, a disintegrin and metalloproteinase domain-containing protein 10. Correspondingly, amyloidogenic β-carboxyl-terminal APP fragment and β-site APP-cleaving enzyme 1 expression levels were reduced. In parallel, the ratio of β- to α-carboxyl-terminal APP fragment was decreased. OG and FA combination therapy strikingly attenuated neuroinflammation, oxidative stress, and synaptotoxicity. Co-treatment afforded additional statistically significant benefits on some, but not all, of these outcome measures. Taken together, these data provide preclinical proof-of-concept for AD combination therapy.

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“…Firstly, the active alkaloid and acetylcholinesterase inhibitor piperine can protect against neurodegeneration and cognitive impairment in a rat model of AD [28]. Secondly, the antioxidant and anti-inflammatory polyphenol gallic acid is able to decrease Aβ toxicity [29], to reduce amyloid fibril formation [30] and to attenuate neuronal damage by preventing Aβ oligomerization [31]. Thirdly, the antioxidant and NFκB inhibitor p-coumaric acid as well as the phenolic compound caffeic acid protect against Aβ25–35-induced neurotoxicity respectively in vitro in PC12 cells [32] and in vivo in rats [33].…”

Section: Discussionmentioning

confidence: 99%

The Polyherbal Wattana Formula Displays Anti-Amyloidogenic Properties by Increasing α-Secretase Activities

Htoo¹,

Limsuvan²,

Thamsermsang³

et al. 2017

PLoS ONE

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Alzheimer’s disease is characterized by the deposition of insoluble amyloid-β peptides produced from the β-amyloid precursor protein (βAPP). Because α-secretase cleavage by ADAM10 and ADAM17 takes place in the middle of Aβ, its activation is considered as a promising anti-AD therapeutic track. Here we establish that the polyherbal Wattana formula (WNF) stimulates sAPPα production in cells of neuronal and non-neuronal origins through an increase of both ADAM10 and ADAM17 catalytic activities with no modification of BACE1 activity and expression. This effect is blocked by specific inhibition or genetic depletion of these disintegrins and we show that WNF up-regulates ADAM10 transcription and ADAM17 maturation. In addition, WNF reduces Aβ40 and Aβ42 generation in human cell lines. Altogether, WNF presents all the characteristics of a potent preventive anti-Alzheimer formula. Importantly, this natural recipe, currently prescribed to patients for the treatment of other symptoms without any secondary effect, can be tested immediately for further clinical studies.

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Effect of Gallic Acid on Dementia Type of Alzheimer Disease in Rats: Electrophysiological and Histological Studies

Cited by 57 publications

References 45 publications

Neuroprotective and Cognitive‐Enhancing Effects of Microencapsulation of Mulberry Fruit Extract in Animal Model of Menopausal Women with Metabolic Syndrome

Neuroprotective and Cognitive‐Enhancing Effects of Microencapsulation of Mulberry Fruit Extract in Animal Model of Menopausal Women with Metabolic Syndrome

Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer's disease

The Polyherbal Wattana Formula Displays Anti-Amyloidogenic Properties by Increasing α-Secretase Activities

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