Effect of Garlic and Atorvastatin on Leptin and Lipid Profile in Triton X-100 Induced Hyperlipidemia in Rats

Abstract

Hyperlipidemia is widely known to be the major risk factor for the development of cardiovascular diseases. This study was conducted to determine the effect of Garlic on Leptin hormone and Lipid Profile in Triton x-100 induced hyperlipidemic rats compared with standard hypolipidemic Atorvastatin. A total number of 60 albino rats were allocated into six equal groups, 10 rats each. The first group was kept on Standard pellet diet (served as normal control), the second group was kept on 1% garlic added to standard pellet diet, the third group was administered with standard Atorvastatin 10 mg/kg p.o. daily (served as standard), the forth group was given a single dose of triton at a dose 100 mg/kg and repeated every two weeks, i.p. (served as Triton control), fifth and sixth groups were given a single dose of triton at a dose 100 mg/kg and repeated every two weeks, i.p. and the fifth group was given garlic 1% added to standard pellet diet while sixth group was administered with standard Atorvastatin 10 mg/kg Effect Of Garlic And Atorvastatin On Leptin And … Nabil M. Taha et., al.