Effect of garlic on cardiovascular disorders: a review

Abstract

<p>Abstract</p> <p>Garlic and its preparations have been widely recognized as agents for prevention and treatment of cardiovascular and other metabolic diseases, atherosclerosis, hyperlipidemia, thrombosis, hypertension and diabetes. Effectiveness of garlic in cardiovascular diseases was more encouraging in experimental studies, which prompted several clinical trials. Though many clinical trials showed a positive effect of garlic on almost all cardiovascular conditions mentioned above, however a number of negative studies have recently cast doubt on the efficary of garlic specially its cholesterol lowering effect of garlic. It is a great challenge for scientists all over the world to make a proper use of garlic and enjoy its maximum beneficial effect as it is the cheapest way to prevent cardiovascular disease. This review has attempted to make a bridge the gap between experimental and clinical study and to discuss the possible mechanisms of such therapeutic actions of garlic.</p

A new gaseous signaling molecule emerges: Cardioprotective role of hydrogen sulfide

“…Previous studies indicate that dietary garlic consumption is inversely correlated with the progression and severity of CV disease and that it affects a lower incidence of hypertension (5). However, the mechanism(s) by which consumption of garlic attenuates CV disease has in large part remained a mystery.…”

The Functional Role of Garlic and Bioactive Components in Cardiovascular and Cerebrovascular Health: What We Do Know

“…Allicin could also exhibit hypotensive properties as reported in the studies where its oral administration to rats with arterial hypertension leads to a marked hypotensive effect [54]. Allicin is believed to be a systematic vasodilator prostacyclin synthase but dilates the mesenteric circulation in cats independent of prostaglandin release or β-adrenergic mechanism [32].…”

The industrial potential of herbs and spices &#8211; a mini review

“…Dietary therapy is the fi rst step in the treatment of cardiac problems (Rahman, 2001). Garlic and onion have been used for millenia in the traditional medical practices of many cultures to treat cardiovascular disease and other disorders (Ali et al, 1999;Banerjee et al, 2002;Bordia et al, 1998;Davison et al, 2012;Kendler, 1987;Kleijnen et al, 1989;Rahman, 2001). Both Allium species, their extracts, and the chemical constituents of these plants have been investigated for combatting cardiovascular disease risk factors (hyperlipidemia, hypertension and hyperglycemia) and suspected risk factors (platelet aggregation and blood fi brinolytic activity) (Kendler, 1987).…”