Effect of garlic powder tablet on carotid intima-media thickness in patients with coronary artery disease

Mahdavi-Roshan, Marjan; Zahedmehr, Ali; Mohammadzadeh, Ali; Sanati, Hamid Reza; Shakerian, Farshad; Firouzi, Ata; Kiani, Reza; Nasrollahzadeh, Javad

doi:10.1177/0260106014563446

Cited by 35 publications

(24 citation statements)

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“…It was shown in 2-year double-blinded placebo-controlled trial that Allicor administration leads to cIMT reduction by -0.022mm per year while in placebo group the progression of cIMT was observed with mean annual rate +0.015mm (p < 0.001) (Orekhov et al, 2013;Karagodin et al, 2016b). Another study of garlic powder tablets efficacy on carotid atherosclerosis showed the similar beneficial data, cIMT dynamics differed significantly between verum and placebo groups (p < 0.001): 3-month cIMT reduction -0.009mm in garlic-administrated group vs. 3-months cIMT progression +0.004mm in placebo-administrated group; only preliminary results of this study were published for this moment (Mahdavi-Roshan et al, 2013). An important area of research is the correction of atherosclerotic changes in postmenopausal women.…”

Section: Potential Direct Anti-atherosclerotic Efficacy Of Medicinal mentioning

confidence: 59%

“…Medicinal plants facilitate the treatment of atherosclerosis using different pathway and various mechanisms of the action, a number of medicinal plants have prospects for the prevention or treatment of atherosclerosis. However, direct anti-atherosclerosis activity of preparations based on garlic powder was studied wider than others natural products, their ameliorating effect on the progression of cIMT was proved in randomized double-blinded placebo-controlled trials, registrated on https://clinicaltrials.gov/ (Hodis et al, 2011;Mahdavi-Roshan et al, 2013;Karagodin et al, 2016aKaragodin et al, 2016b. Garlic preparations have the most interesting and obvious cardio-protective properties since garlic is able to ameliorate the blood lipids profile by inhibiting cholesterol biosynthesis, reducing of LDL, modulate arterial hypertension, and inhibit platelet aggregation (Sobenin et al, 2008a;Sobenin et al, 2008b;Sobenin et al, 2009;Jung et al, 2014;Mahdavi-Roshan et al, 2016;Myasoedova et al, 2016;Villa et al, 2017;Choudhary et al, 2018;Sathyapalan et al, 2018;Panahi et al, 2018;Xu et al, 2018;Sedaghat et al, 2019;Adibian et al, 2019;Adab et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

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Medicinal Plants as a Potential and Successful Treatment Option in the Context of Atherosclerosis

et al. 2020

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Atherosclerosis is a chronic multifactorial disease characterized by mainly changes of blood lipids profile and inflammation in vessel wall. The cardiovascular disease based on atherosclerosis is currently the leading cause of mortality in developed countries. Therefore, timely prevention and therapy of atherosclerosis are able to reduce the risk of the development of its clinical manifestations. Anti-atherosclerotic activity of medicinal plants mainly appears in their multiple effects such as anti-inflammatory, antioxidant, antiatherogenic, hypotensive, lipid-lowering, anti-thrombotic. Moreover, most of medicinal plants are characterized by their pleiotropic anti-atherosclerotic action. In addition, the medicinal plants-derived pharmacological substances and/or compounds are characterized by relative safety and fewer side effects that allows considering them as one of potential anti-atherosclerotic effective agents. The direct anti-atherosclerotic effect of some medicinal plants was confirmed in clinical trials of carotid Intima-media thickness (IMT) progression during long-term medication with medicinal plants. This review attempted to determine the current status of the databases PubMed and Scopus (until November, 2019) to investigate the medicinal plants possessing anti-atherosclerotic activity in experimental and clinical studies.

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Section: Potential Direct Anti-atherosclerotic Efficacy Of Medicinal mentioning

confidence: 59%

Section: Resultsmentioning

confidence: 99%

Medicinal Plants as a Potential and Successful Treatment Option in the Context of Atherosclerosis

et al. 2020

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“…For hypercholesterolemia, the reported effects of garlic are small and may be of no clinical relevance [28]. However, the question is under discussion [29]; therefore, reliability of published reports is critical, the more so as the literature is abundant today. Some results obtained in vitro or ex vivo by the same researchers, such as anti-…”

Section: Discussionmentioning

confidence: 99%

Development of Antiatherosclerotic Drugs on the Basis of Cell Models: A Comment

Jargin

2015

IJPPE

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The large research series has become internationally known in the 1980s and continues until today. Cultures of cultured or incubated smooth muscle cells or monocytes/macrophages were used for the measurement of capacities of substances to enhance or lower intracellular cholesterol deposition, which was interpreted as anti-or pro-atherogenic action. The LDL from patients with coronary atherosclerosis caused a 2-4 times elevation of cholesterol contents within the cultured cells. Incubation with sera or LDL from healthy subjects did not induce cholesterol accumulation. Various drugs and natural substances were found to possess pro-or anti-atherogenic potencies. Anti-atherogenic effect of different preparations of plant origin was reported: if an agent induced intracellular lipid accumulation it was regarded atherogenic and vice versa. However, if a pharmacological agent lowers the uptake of lipids by cells in a culture, it should be expected to increase the blood cholesterol level in vivo. It can be reasonably assumed that a drug, inhibiting cholesterol uptake by cultured cells, would elevate the blood cholesterol level in vivo. By analogy with familial hypercholesterolemia, it might contribute to atherosclerosis: lipids would be deposited into the intercellular/subendothelial space of the vascular wall, in sites with damaged endothelial barrier and vulnerable plaques. The agents supposedly having an anti-atherogenic potency in a cell culture might reduce cholesterol uptake diffusely by entire cell populations contributing thereby to hypercholesterolemia. On the contrary, atherosclerosis is a focal disease, affecting primarily damaged sites of the vascular lining, which would be favored by hypercholesterolemia.

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“…Atherosclerosis is a systemic disease responsible for most incidences of CVD s and stroke [5]. Atherosclerosis is a complex phenomenon that is the main cause of coronary artery disease, which can be illustrated an excess of fibro-fatty substance, or the accumulation of atheroma plaques, is an inflammatory response toward arterial wall damage [6,7]. Exposure to cigarette smoke is one of the main risk factors toward the early development of atherosclerosis and other CVD complications.…”

Section: Introductionmentioning

confidence: 99%

Atheroprotective Effect of Solanum Betaceum on Rat Exposed to Cigarette Smoke

et al. 2019

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Objective: The objective of this research was to determine the atheroprotective effect of Solanum betaceum ethanol extract toward carotid arteryintima-media thickness (cIMT) and the level of malondialdehyde (MDA) on rats exposed to cigarette smoke.Methods: Thirty adult Rattus norvegicus strain Wistar were divided into five groups and exposed to cigarette smoke, 3 pc cigarette/day andsimultaneously administered with S. betaceum in Group K2, K3, and K4 (100 mg/kg b.w/day; 200 mg/kg b.w/day; and 400 mg/kg b.w/day),respectively. The duration of treatment for all groups was 28 days. Blood was withdrawn from the cardiac to determine the MDA level. Histologicalslide from carotid artery intima-media was collected to determine cIMT.Results: S. betaceum ethanol extract administration could significantly prevent the development of atherosclerosis due to oxidative stress bydecreasing the level of MDA (p<0.05) and reducing the degree of cIMT changes (p<0.05).Conclusion: The present study found that S. betaceum ethanol extract could prevent the development of atherosclerosis due to smoke exposurethrough the reduction of the MDA level, i.e., the marker of oxidative stress, which is associated with the reduced of cIMT changes. However, furtherstudies on other bioactivity of S. betaceum as an antioxidant are warranted.

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Effect of garlic powder tablet on carotid intima-media thickness in patients with coronary artery disease

Abstract: The results suggest that dry garlic powder tablet is superior to placebo in prevention of CIMT progression in patients with CAD and may be considered as an adjunct treatment for atherosclerosis.

Cited by 35 publications

References 39 publications

Medicinal Plants as a Potential and Successful Treatment Option in the Context of Atherosclerosis

Medicinal Plants as a Potential and Successful Treatment Option in the Context of Atherosclerosis

Development of Antiatherosclerotic Drugs on the Basis of Cell Models: A Comment

Atheroprotective Effect of Solanum Betaceum on Rat Exposed to Cigarette Smoke

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