Effect of Gastrodiae elata Blume Components on Systolic Blood Pressure and Serum Lipid Concentrations in Spontaneously Hypertensive Rats Fed High Fat Diet

Hong, Hee‐Do; Shim, Eun-Jung; Kim, Kyung-Im; Choi, Sang‐Yoon; Han, Chan-Kyu

doi:10.3746/jkfn.2007.36.2.174

Cited by 5 publications

(11 citation statements)

References 8 publications

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“…The crude polysaccharide exhibited the most potent antihypertensive action compared with the protein fraction and low-molecular-weight fraction [9]. It was further fractionated by ion-exchange chromatography on DEAE-Sepharose CL-6B.…”

Section: Resultsmentioning

confidence: 99%

“…In our previous study [ 9 ], a hot-water extract of Gastrodia rhizome was fractionated to obtain a crude polysaccharide (GR-0). The crude polysaccharide exhibited the most potent antihypertensive action compared with the protein fraction and low-molecular-weight fraction [ 9 ]. It was further fractionated by ion-exchange chromatography on DEAE-Sepharose CL-6B.…”

Section: Resultsmentioning

confidence: 99%

“…As shown in Table 4 , both crude polysaccharide (6 mg/kg) and acidic polysaccharide (6 mg/kg) were administered by oral gavage to SHR. The dose of crude and acidic polysaccharides were set by considering effective dose of antihypertensive fractions of hot water and crude polysaccharide ranging from 3.6 to 14.7 mg/kg of body weight/day in SHRs [ 9 , 24 ]. Acidic polysaccharides were consisting of 12.56% in fraction of crude polysaccharide.…”

Section: Methodsmentioning

confidence: 99%

“…Treatment with polysaccharide fraction of mushroom species such as Pleurotus nebrodensis in SHR showed antihypertensive effect via the inhibition of angiotensin conversion [ 8 ]. We previously reported [ 9 ] that the anti-hypertensive action of macromolecules such as crude polysaccharides from Gastrodia rhizome in SHR is significantly stronger than that of the protein fraction and low-molecular-weight fraction (phenolic compound).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Acidic Polysaccharides from Gastrodia Rhizome on Systolic Blood Pressure and Serum Lipid Concentrations in Spontaneously Hypertensive Rats Fed a High-Fat Diet

Lee

Kim

Han

et al. 2012

IJMS

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The effects of acidic polysaccharides purified from Gastrodia rhizome on blood pressure and serum lipid levels in spontaneously hypertensive rats (SHR) fed a high-fat diet were investigated. Acidic polysaccharides were purified from crude polysaccharides by DEAE-Sepharose CL-6B. Thirty-six male SHR were randomly divided into three groups: Gastrodia rhizome crude polysaccharide (A), acidic polysaccharide (B) groups, and a control group (C). A 5-week oral administration of all treatment groups was performed daily in 3- to 8-week-old SHRs with a dose of 6 mg/kg of body weight/day. After 5 weeks of treatment, total cholesterol in the acidic polysaccharide group, at 69.7 ± 10.6 mg/dL, was lower than in the crude polysaccharide group (75.0 ± 6.0 mg/dL) and the control group (89.2 ± 7.4 mg/dL). In addition, triglyceride and low-density lipoprotein cholesterol levels in the acidic polysaccharide group were lower than in the crude polysaccharide and control groups. The atherogenic index of the acidic polysaccharide group was 46.3% lower than in the control group. Initial blood pressure after the initial three weeks on the high-fat diet averaged 195.9 ± 3.3 mmHg among all rats. Compared with the initial blood pressure, the final blood pressure in the control group was increased by 22.8 mmHg, whereas it decreased in the acidic polysaccharide group by 14.9 mmHg. These results indicate that acidic polysaccharides from Gastrodia rhizome reduce hypertension and improve serum lipid levels.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Acidic Polysaccharides from Gastrodia Rhizome on Systolic Blood Pressure and Serum Lipid Concentrations in Spontaneously Hypertensive Rats Fed a High-Fat Diet

Lee

Kim

Han

et al. 2012

IJMS

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“…마의 주요 생리활성으로는 관상순환 기능 향상 , 지질성분 개선 (Cho et al 2008;Kwon et al 2001;Hong et al 2007;Yang 2008), 혈류개선 (Park et al 2005;Park et al 2007), 혈압강하 (Hong et al 2007;Park et al 2005;Park et al 2007), 신경안정작용 (Sung 1996), 혈당개선 (Kwon et al 2001 …”

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The Quality Characteristics of Backsulgi Prepared with Yam(Dioscorea japonica) Powder

Kim¹

2012

The Korean Journal of Community Living Science

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Yam(Dioscorea japonica) has been used in oriental medicine to modulate physiology, and it is considered as a potential functional food. So far, however, limited efforts has been performed to use yam for food processing and development. Thus, in this study, rice cakes called 'Backsulgi' containing 3%, 6% and 9% yam powder were prepared and the quality characteristics were evaluated. The results of this study showed that adding yam powder reduced the moisture content of Backsulgi, which led to a decrease in the strength of textural characteristics such as hardness, adhesiveness, cohesiveness, gumminess, chewiness, and springiness. In contrast, the quality characteristics of the sample containing 3% yam powder were not significantly different from those of the control in moisture content, texture, and overall acceptability. Consequently, adding 3% yam powder could improve the biofunctionality and quality characteristics of Backsulgi in the case of adjusting moisture content.

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Acidic Polysaccharide Extracts from Gastrodia Rhizomes Suppress the Atherosclerosis Risk Index through Inhibition of the Serum Cholesterol Composition in Sprague Dawley Rats Fed a High-Fat Diet

Kim

Lee

Han

et al. 2012

IJMS

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Obesity is associated with a broad spectrum of cardio-metabolic disturbances, including atherosclerosis and cardiovascular disease (CDV). A high-fat diet has been shown to cause an elevation of the plasma cholesterol levels in humans, and the control of serum cholesterol has been demonstrated to be important in the prevention of CVD and atherosclerosis. The aims of this study were to demonstrate that crude and acidic polysaccharide extracts from Gastrodia rhizomes suppress atherosclerosis through the regulation of serum lipids in Sprague Dawley (SD) rats fed a high-fat diet. We examined the concentrations of serum lipids, including total cholesterol, triglycerides, high-density lipoproteins (HDL) cholesterol, and low-density lipoproteins (LDL) cholesterol, in SD rats fed a high-fat diet and evaluated the atherogenic index. Here, we show that both crude and acidic polysaccharide extracts from Gastrodia rhizomes inhibited the total cholesterol and LDL levels. Moreover, there was a significantly suppressed atherosclerosis risk due to the acidic polysaccharide extract from Gastrodia rhizome. Taken together, our results suggested that acidic polysaccharide extracts from Gastrodia rhizomes might be beneficial for lowering the incidence of CVD and atherosclerosis by reducing the de novo synthesis of total cholesterol and the LDL levels.

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Effect of Gastrodiae elata Blume Components on Systolic Blood Pressure and Serum Lipid Concentrations in Spontaneously Hypertensive Rats Fed High Fat Diet

Cited by 5 publications

References 8 publications

Effects of Acidic Polysaccharides from Gastrodia Rhizome on Systolic Blood Pressure and Serum Lipid Concentrations in Spontaneously Hypertensive Rats Fed a High-Fat Diet

Effects of Acidic Polysaccharides from Gastrodia Rhizome on Systolic Blood Pressure and Serum Lipid Concentrations in Spontaneously Hypertensive Rats Fed a High-Fat Diet

The Quality Characteristics of Backsulgi Prepared with Yam(Dioscorea japonica) Powder

Acidic Polysaccharide Extracts from Gastrodia Rhizomes Suppress the Atherosclerosis Risk Index through Inhibition of the Serum Cholesterol Composition in Sprague Dawley Rats Fed a High-Fat Diet

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