Effect of GBR 12909 and fluoxetine on the acute and long term changes induced by MDMA (‘ecstasy’) on the 5-HT and dopamine concentrations in mouse brain

O’Shea, Esther; Esteban, Basilio Moreno; Camarero, Jorge; Green, A.R.; Colado, M. Isabel

doi:10.1016/s0028-3908(00)00106-4

Cited by 92 publications

(93 citation statements)

References 42 publications

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“…MDMA administration decreased the concentration of striatal DA when administered at high doses (20 mg/kg) in agreement with previous reports (for review see , but cocaine inhibited this decrease in DA concentration three weeks later (Daza-Losada et al, 2008a). In accordance with these results, pretreatment with the dopamine uptake inhibitor GBR 12909 prevented long-term loss in the striatal concentration of DA (O'Shea et al, 2001). This lack of neurotoxicity could have been due to the effect exerted on body temperature by the two drugs together, as cocaine is known to counteract the increase produced by neurotoxic doses of MDMA.…”

Section: Mdma Plus Cocainesupporting

confidence: 91%

Polydrug Use in Adolescence

Rodrı́guez-Arias¹,

Aguilar²

2012

Addictions - From Pathophysiology to Treatment

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Section: Mdma Plus Cocainesupporting

confidence: 91%

Polydrug Use in Adolescence

Rodrı́guez-Arias¹,

Aguilar²

2012

Addictions - From Pathophysiology to Treatment

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“…Alcohol consumption has been found to impair this adaptive control function (Ridderinkhof et al 2002a). Considering the reported effects of MDMA consumption on the DA system (O'Shea et al 2001) and its effects on adaptive control observed in the present study, future research should aim also at addressing the effects of MDMA on action monitoring.…”

Section: Discussionmentioning

confidence: 66%

“…MDMA is toxic to the serotonin (5-HT) system (Battaglia et al 1988;Pan and Wang 1990), and, to a lesser extent, to the dopamine (DA) system (O'Shea et al 2001). This neurotoxic effect presumably also occurs in humans ).…”

Section: Introductionmentioning

confidence: 99%

“…In comparison with the extensive study of neurotoxic effects on serotonergic neurocognitive function, the effects on DA-mediated executive functions (EF) of the human frontal lobes have been explored less systematically. However, reports have begun to highlight toxic effects of MDMA on the DA system (O'Shea et al 2001) and on executive function in human MDMA users. For instance, MDMA users scored lower on the Behavioral Assessment of Dysexecutive Syndrome, a test designed to measure mental organization, planning strategies, thinking ahead, mental rule forming, and the estimation of temporal activities (Zakzanis and Young 2001b).…”

Section: Introductionmentioning

confidence: 99%

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Impaired executive function in male MDMA (?ecstasy?) users

et al. 2004

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Impaired executive function in male MDMA ("ecstacy") usersAlting von Geusau, N.; Stalenhoef, P.; Huizinga, M.; Snel, J.; Ridderinkhof, K.R. Published in: Psychopharmacology DOI:10.1007/s00213-004-1832-8 Link to publication Citation for published version (APA):Alting von Geusau, N., Stalenhoef, P., Huizinga, M., Snel, J., & Ridderinkhof, K. R. (2004). Impaired executive function in male MDMA ("ecstacy") users. Psychopharmacology, 175(3), 331-341. DOI: 10.1007/s00213-004-1832-8 General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Download date: 11 May 2018Psychopharmacology (2004) Methods: MDMA users and controls who abstained from ecstasy and other substances for at least 2 weeks were tested with a computerized cognitive test battery to assess their abilities on tasks that measure the three submodalities of executive function, and their combined contribution on two more complex executive tasks. Because of sex-differential effects of MDMA reported in the literature, data from males and females were analyzed separately. Results: Male MDMA users performed significantly worse on the tasks that tap on cognitive flexibility and on the combined executive function tasks; no differences were found on the other cognitive tasks. Female users showed no impairments on any of the tasks.Conclusions: The present data suggest that a history of MDMA use selectively impairs executive function. In male users, cognitive flexibility was impaired and increased perseverative behavior was observed. The inability to adjust behavior rapidly and flexibly may have repercussions for daily life activities.

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“…To further explore the substrate properties of MDMA, we compared MDMA affinities for inhibiting radiolabeled inhibitor binding to the DAT, NET, and SERT with affinities for blocking monoamine transport, as substrates display relatively weak affinities at radioligand binding sites, whereas transport inhibitor potencies at radiolabeled sites usually correspond to their affinities for blocking the transport of monoamines (Madras et al 1989a,b;Goulet et al 2001;Eshleman et al 1995Eshleman et al , 1999. Our third objective was to monitor the capacity of MDMA to release sequestered monoamines from transporter-expressing cultured cells, as MDMA promotes monoamine release in vivo (except NE) and in vitro (Yamamoto and Spanos 1988;Johnson et al 1986;Fitzgerald and Reid 1990;Gough et al 1991;Gudelsky and Nash 1996;Rothman et al 2001;Zaczek et al 1990;O'Shea et al 2001;Mechan et al 2002;Nash and Brodkin 1991;Koch and Galloway 1997).…”

Section: Introductionmentioning

confidence: 99%

MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment

2005

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Rationale: 3,4-Methylenedioxymethamphetamine (MDMA, designated as "Ecstasy" if illicitly marketed in tablet form) induces significant decrements in neuronal serotonin (5-HT) markers in humans, nonhuman primates, and rats as a function of dosing and dosing regimen. In rats, MDMA-mediated effects are attributed, in part, to selective high-affinity transport of MDMA The affinity of MDMA for the human SERT in transfected cells does not clarify the apparent selective toxicity of MDMA for serotonin neurons, although conceivably, its higher efficacy for stimulating 5-HT release may be a distinguishing factor. The findings highlight the need to investigate MDMA effects in DAT-, SERT-, and NET-expressing neurons in the primate brain and the therapeutic potential of NET or DAT inhibitors, in addition to SERT-selective inhibitors, for alleviating the pharmacological effects of MDMA.

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Effect of GBR 12909 and fluoxetine on the acute and long term changes induced by MDMA (‘ecstasy’) on the 5-HT and dopamine concentrations in mouse brain

Cited by 92 publications

References 42 publications

Polydrug Use in Adolescence

Polydrug Use in Adolescence

Impaired executive function in male MDMA (?ecstasy?) users

MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment

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