Effect of gemfibrozil on cardiotoxicity induced by doxorubicin in male experimental rats

Haybar, Habib; Goudarzi, Mehdi; Mehrzadi, Saeed; Aminzadeh, Azadeh; Khodayar, Mohammad Javad; Kalantar, Mojtaba; Fatemi, Iman

doi:10.1016/j.biopha.2018.10.101

Cited by 38 publications

(32 citation statements)

References 30 publications

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“…Recently, Lee and Pyo [60] reported that AA promoted adipocyte differentiation and intracellular lipid accumulation via regulation of the expression of adipogenesis-related genes and AMPK and MAPK signaling. Experimental studies in rodents have shown that lipid-lowering agents with antioxidant properties were able to protect the myocardium against cardiotoxicity conditions induced by other drugs/pharmaceuticals (e.g., doxorubicin and cyclophosphamide) [50,61]. Our results showed that SIL treatment in AA-intoxicated rats caused an overall reduction of the elevated serum lipids (TC and TGs) and improvements in the lipoprotein profile.…”

Section: Sil Improves Cardiac Histopathologysupporting

confidence: 49%

“…Elevated serum levels of CPK and LDH have been indicated for cardiac tissue dysfunctions because these enzymes are normally located in the cytoplasm of cardiomyocytes and leakage occurs into the plasma or serum a er myocardial injury [50]. CPK promotes the reversible phosphotransfer between the ATP/ADP and creatine/phosphocreatine systems T 3: Effect of silymarin on severity of myocardial lesions in rats treated with acrylamide.…”

Section: Discussionmentioning

confidence: 99%

“…e pathologist (A. M. Abdel-Moneim) performing the evaluation was blinded to the treatment assignments of various study groups. e criteria of myocardial lesions included myocardial disorganization, necrotic injury, leukocyte in ltration, and nuclear pyknosis [39,40]. e severity of every pathological alteration was graded semi quantitatively as previously described [41].…”

Section: Histopathological Studiesmentioning

confidence: 99%

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Silymarin Ameliorates Acrylamide-Induced Hyperlipidemic Cardiomyopathy in Male Rats

Abdel‐Moneim

Alzahrani

Ali

et al. 2019

BioMed Research International

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Acrylamide (AA) is a well-known potent carcinogen and neurotoxin that has been recently linked to atherosclerotic pathogenesis. The present study is aimed at investigating the protective effect of silymarin (SIL) as an antioxidant against AA-induced hyperlipidemic cardiomyopathy in male rats. The obtained results showed that animals exposed to AA exhibited a significant increase in the levels of cardiac serum markers, serum total cholesterol, triglycerides, low-density lipoprotein cholesterol, and very-low-density lipoprotein cholesterol with a significant decrease in high-density lipoprotein cholesterol. Furthermore, AA intoxication significantly increased the malondialdehyde level (a hallmark of lipid peroxidation) and reduced antioxidant enzyme activities (i.e., superoxide dismutase, catalase, and glutathione peroxidase). SIL administration significantly attenuated all these biochemical perturbations in AA-treated rats, except for the decreased high-density lipoprotein cholesterol. Our results were confirmed by histopathological assessment of the myocardium. In conclusion, this study demonstrated a beneficial effect of SIL therapy in the prevention of AA-induced cardiotoxicity by reversing the redox stress and dyslipidemia in experimental animals.

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Section: Sil Improves Cardiac Histopathologysupporting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Section: Histopathological Studiesmentioning

confidence: 99%

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Silymarin Ameliorates Acrylamide-Induced Hyperlipidemic Cardiomyopathy in Male Rats

Abdel‐Moneim

Alzahrani

Ali

et al. 2019

BioMed Research International

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“…After normalization of tumor vessels, we used doxorubicin as the inhibitor of DNA replication that interacts with DNA and results in hindering the macromolecular biosynthesis. Doxorubicin is one of the most common drugs used in cancer therapy such as breast, lung, bladder, stomach, ovaries, soft tissue sarcoma, thyroid, multiple myeloma, and Hodgkin's lymphoma . After treatment with our pH‐sensitive NPs@DA system and having the vessels normalized, this drug has enhanced the performance in mouse tumor models (Scheme b).…”

Section: Introductionmentioning

confidence: 99%

Dopamine Delivery via pH‐Sensitive Nanoparticles for Tumor Blood Vessel Normalization and an Improved Effect of Cancer Chemotherapeutic Drugs

Taleb

Ding

Wang

et al. 2019

Adv Healthcare Materials

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Tumor blood vessels have been reported to be abnormal in both structure and function compared with those in normal tissues, leading to a hostile microenvironment and inadequate antitumor drug delivery. Dopamine, a chemical messenger, is proven to inhibit angiogenesis and improve tumor vessel normalization. Here, a mesoporous silicon nanoparticle (MSN) is constructed that is responsive to the weakly acidic pH of the tumor extracellular matrix for steady delivery and tumor‐localized release of dopamine. Then MSNs are functionalized with amine conjugated phenylboronicacid molecules, and dopamine is loaded by reacting with phenylboronic acid. In a weakly acidic environment, MSNs intelligently release dopamine due to the hydrolysis of boronic‐ester bond between dopamine and phenylboronic acid, resulting in an evident inhibition of vascular endothelial cell migration and tubule formation. It is shown that loading of dopamine into the functional MSNs significantly prolong the circulatory half‐life of this small molecule. After intravenous injection to tumor bearing mice, this nanoformulation induce tumor blood vessel normalization, thereby improving the antitumor chemotherapeutic efficacy of doxorubicin. This study demonstrates that the pH‐responsive MSN offers great potential for delivery of dopamine in vivo and the normalization of tumor vessels by dopamine can provide an auxiliary treatment for cancer chemotherapeutic drugs.

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“…Many research studies evidenced that DOX increases inflammation and oxidative stress in the heart tissue. [1][2][3] Various studies were demonstrated for antioxidants from the natural medicine with target to reduce oxidative stress injury evoked by DOX. Many natural antioxidants were screened to ameliorate the DOX-induced cell damage without compromising its anti-tumor efficacy in the animal studies.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Capsaicin against Doxorubicin Induced Cardiotoxicity in Experimental Rats

Karale¹,

Pv²,

Kamath³

2019

IJPER

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Aim: The aim of the present study was to evaluate the Cardioprotective effect of Capsaicin (CAP) against Doxorubicin (DOX) induced cardiotoxicity in experimental rats. Methods: The 24 wistar rats were randomly divided into four groups (with equal numbers): Normal-1% Dimethyl Sulfoxide (DMSO), DOX (15 mg/kg, i.p), CAP (10 mg/kg, p.o, alone) and CAP 10 mg/kg (in combination with DOX). Cardiotoxicity was induced in wistar rats by administering DOX with a cumulative dose of 15 mg/kg (i.p) for 2 weeks. CAP with a dose of 10 mg/kg was administered in respective groups for 21 days. The influence of the treatment was analysed by quantification of serum biomarkers and antioxidants, electrocardiographic parameters and histopathological observations. Results: In the current study, the activities of Lactate Dehydrogenase (LDH), Creatine Kinase-NAC (CKNAC), Creatine Kinase-MB (CK-MB), were reduced (P<0.001) in serum and Superoxide Dismutase (SOD), Reduced Glutathione (GSH) and Catalase activities were increased (P<0.001) in heart tissue homogenate in all treated groups compared to DOX group. Similarly, the electrocardiographic changes were restored close to normal in all treated groups. Results were further supported by histopathological studies. Conclusion: The results reveal that CAP possesses potential benefits against cardiotoxicity induced by DOX by supressing serum markers and oxidative stress in heart tissues of experimental rats.

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Effect of gemfibrozil on cardiotoxicity induced by doxorubicin in male experimental rats

Cited by 38 publications

References 30 publications

Silymarin Ameliorates Acrylamide-Induced Hyperlipidemic Cardiomyopathy in Male Rats

Silymarin Ameliorates Acrylamide-Induced Hyperlipidemic Cardiomyopathy in Male Rats

Dopamine Delivery via pH‐Sensitive Nanoparticles for Tumor Blood Vessel Normalization and an Improved Effect of Cancer Chemotherapeutic Drugs

Protective Effect of Capsaicin against Doxorubicin Induced Cardiotoxicity in Experimental Rats

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