Silymarin Ameliorates Acrylamide-Induced Hyperlipidemic Cardiomyopathy in Male Rats

Abdel‐Moneim, Ashraf M.; Alzahrani, Abdullah M.; Ali, Alaa E.; Mahmoud, Omar

doi:10.1155/2019/4825075

Cited by 9 publications

(8 citation statements)

References 53 publications

(51 reference statements)

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“…The significant increase in the body weight gain of silymarin treated groups might be attributes to the stabilization action of silymarin to the hepatocytes membranes, which exerted protection to the hepatocytes and improved liver function. Moreover, the stimulatory action of RNA and protein synthesis shown by silymarin could be subsequently improved growth and increased body weight gain (14). Furthermore, many researchers have suggested the stimulatory action of silymarin by increasing the transcription of ribosomal RNA.…”

Section: Discussionmentioning

confidence: 99%

“…Elevated ribosomal production and accelerated protein and DNA biosynthesis could be improving the biosynthesis of structural and functional proteins. Moreover, the stimulatory effect of silymarin may offer more transporters and enzymes, which could enhance different body cells functions (14). Decreased body weight gains in EtBr treated female rats might be associated with the increased oxidative stress, since EtBr toxicity leads to cellular antioxidant defense capacity overloading.…”

Section: Discussionmentioning

confidence: 99%

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Ovario-utero protective effect of silymarin in ethidium bromide treated female rats

Abdulshaheed¹,

Al-Saaidi²,

Al-Arak³

2022

IJVS

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This study was conducted to qualify the ameliorating potency of silymarin against toxicity in ethidium bromide (EtBr) treated female rats. Eighty female Wistar rats aged 100 days, weighted 170-175 g were randomly allocated to control, orally supplemented with drinking water, and three treated groups, orally supplemented with silymarin 200 mg/kg BW, EtBr 10 mg/kg BW, and combination of EtBr and silymarin (SEtBr), respectively. Each group was allocated to two subgroups, sacrificed after 20 and 40 days of treatment. Bodyweight gain, uteri, and ovaries weight were recorded. Ovarian samples were obtained for histopathological examination. EtBr group females recorded the lowest body weight gain, relative weights of ovaries and uteri, and ovarian follicle number, whereas S group females recorded the highest body weight gain and follicular number, while the ovaries and uteri weights were either higher or close to the control group, at both experimental periods. Histopathological findings of both periods revealed necrosis, cirrhosis, ischemia, and prominent hemorrhage in the blood capillaries in EtBr treated ovarian tissues, but many of the ovarian follicles being mature and the atretic follicles were hence found to be high in number, whereas silymarin treated females showed normal ovarian tissues and viable ovarian follicles as that in control females. The combinationtreated females, at 20 days, revealed necrotic primary ovarian follicles with some macrophages infiltration, whereas 40 days' period showed normal ovarian cortex, medulla, and ovarian follicles. In conclusion, silymarin treatment in combination with EtBr has a potent amelioration effect against ovarian toxicity, in a duration-dependent manner.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ovario-utero protective effect of silymarin in ethidium bromide treated female rats

Abdulshaheed¹,

Al-Saaidi²,

Al-Arak³

2022

IJVS

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“…This might result from the different behavior and sensitivity of the used model organism toward AA, different doses, and exposition times of AA, and/or due to manipulation of the model organism that already caused stress. However, the remaining common characteristic is the protection of the model organism against AA-induced oxidative stress via substances with antioxidant properties [38][39][40]. Taken together, the presented results showed that AsA pre-treatment significantly reduces ROS levels and promotes SOD and CAT activity to protect cells exposed to AA.…”

Section: Discussionmentioning

confidence: 63%

Acrylamide-Derived Ionome, Metabolic, and Cell Cycle Alterations Are Alleviated by Ascorbic Acid in the Fission Yeast

et al. 2022

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Acrylamide (AA), is a chemical with multiple industrial applications, however, it can be found in foods that are rich in carbohydrates. Due to its genotoxic and cytotoxic effects, AA has been classified as a potential carcinogen. With the use of spectrophotometry, ICP-OES, fluorescence spectroscopy, and microscopy cell growth, metabolic activity, apoptosis, ROS production, MDA formation, CAT and SOD activity, ionome balance, and chromosome segregation were determined in Schizosaccharomyces pombe. AA caused growth and metabolic activity retardation, enhanced ROS and MDA production, and modulated antioxidant enzyme activity. This led to damage to the cell homeostasis due to ionome balance disruption. Moreover, AA-induced oxidative stress caused alterations in the cell cycle regulation resulting in chromosome segregation errors, as 4.07% of cells displayed sister chromatid non-disjunction during mitosis. Ascorbic acid (AsA, Vitamin C), a strong natural antioxidant, was used to alleviate the negative impact of AA. Cell pre-treatment with AsA significantly improved AA impaired growth, and antioxidant capacity, and supported ionome balance maintenance mainly due to the promotion of calcium uptake. Chromosome missegregation was reduced to 1.79% (44% improvement) by AsA pre-incubation. Results of our multiapproach analyses suggest that AA-induced oxidative stress is the major cause of alteration to cell homeostasis and cell cycle regulation.

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“…For neutralizing of free radicals adverse effects, the body has protective barriers like antioxidant enzymes (superoxide dismutase (SOD), catalase, glutathione S-transferase, glutathione peroxidase) and proteins like GSH (Zamani et al, 2017). ACR generates free radicals disrupting the antioxidative state leading to oxidative stress (Abdel-Moneim et al, 2019). This was confirmed in the current study by increasing the blood levels of H 2 O 2 , MDA and NO, this increase is a dose and duration dependants (table 1).…”

Section: Discussionmentioning

confidence: 99%

“…The increase in free radicals and peroxide leads to induction of antioxidant system to compensate that increase till the depletion of antioxidants leading to the decrease of antioxidant levels. Blood antioxidant system include nonenzymatic antioxidant as GSH and enzymatic antoxidants as SOD, catalas, GR and GPx (Abdel-Moneim et al, 2019). Vitamin C is considered the most important water-soluble antioxidant in mammalian cells.…”

Section: Discussionmentioning

confidence: 99%

In vetro study on the toxic effects of acrylamide on blood antioxidants, ameliorative effects of vitamin C

Ghamdi

Alenezi

Algoferi

et al. 2020

Preprint

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Background: Acrylamide (ACR) is a naturally occurring, widely used compound, it is generated during cocking carbohydrate rich food at high temperature. Ingestion of large amounts of ACR underlies several health concerns and teratogenicity. Ascorbic acid (vit C) is a strong reducing agent greatly used to clean free radicals. Materials and methods:Blood sample was obtained from 46 years old, healthy nonsmoking man in heparinized tubs. Blood sample was immediately divided into seven parts as triplet for each. The first one was leaved as control, 2nd, 3rd and the 4th were treated with acrylamide in a concentration of 25,50 and 100 mM respectively, the 5th, 6th and the 7th were treated with acrylamide as the mentioned concentrations and vitamin C in a concentration of 100mM.Samples (one mile litter) from each tube were taken after four and 24 hours and were used for preparation of hemolysates, that were kept at -80°C till investigation of the biochemical parameters. Results: The concentrations of Malondialdehyd (MDA), nitric oxide (NO) and hydrogen peroxide (H2O2) increased in ACR and/or vit. C treated samples as compared with control. The concentration of reduced glutathione (GSH) and activities of Catalase (CAT), Superoxide dismutase (SOD), Glutathione reductase (GR), Glutathione peroxidase (GPx) and glucose 6 phosphate dehydrogenase (G6PDH) decreased significantly in ACR and/or vit. C treated samples as compared with control. Meanwhile, The concentrations of MDA, NO and H2O2 decreased in samples treated with both ACR and vit. C as compared with that treated with ACR only. The concentration of GSH and activities CAT, SOD, GR, GPx and G6PDH increased significantly in samples treated with both ACR and vit. C as compared with that treated with ACR only.Conclusion: ACR produce it's toxic effect through it's deleterious action on the antioxidant system through induction of pro-oxidants leading to exhausting of antioxidants. Vitamin C has an ameliorative action on the deleterious action exerted by ACR through improving the balance between pro-oxidants and antioxidant.

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Silymarin Ameliorates Acrylamide-Induced Hyperlipidemic Cardiomyopathy in Male Rats

Cited by 9 publications

References 53 publications

Ovario-utero protective effect of silymarin in ethidium bromide treated female rats

Ovario-utero protective effect of silymarin in ethidium bromide treated female rats

Acrylamide-Derived Ionome, Metabolic, and Cell Cycle Alterations Are Alleviated by Ascorbic Acid in the Fission Yeast

In vetro study on the toxic effects of acrylamide on blood antioxidants, ameliorative effects of vitamin C

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