Effect of gestational diabetes mellitus and pregnancy-induced hypertension on human umbilical vein smooth muscle KATP channels

Djokic, Vladimir; Jankovic-Raznatovic, Svetlana; Novaković, R; Kostić, Milan; Rajković, Jovana; Labudović‐Borović, Milica; Rakočević, Jelena; Stanišić, Jelena; Djurić, M.; Gojkovic-Bukarica, Ljiljana

doi:10.1016/j.yexmp.2019.104323

Cited by 14 publications

(18 citation statements)

References 53 publications

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“…This decrease may underlie the subsequent depolarization of the membrane and, therefore, a consequent increase in vascular tonus observed in this pathology [ 16 ]. In the last year, Djokic et al (2019) also demonstrated that during gestational hypertension, the function of the Kv channels was compromised as they observed an absence of inhibition of the functional response to pinacidil (K ATP channel opener) [ 138 ]. The authors also demonstrated that 4-AP significantly decreases vasorelaxation induced by pinacidil in vascular SMCs of HUV from normotensive pregnant subjects, but not in hypertensive pregnant subjects [ 138 ].…”

Section: Clinical Importance and Medical Uses Of K + mentioning

confidence: 99%

“…In the last year, Djokic et al (2019) also demonstrated that during gestational hypertension, the function of the Kv channels was compromised as they observed an absence of inhibition of the functional response to pinacidil (K ATP channel opener) [ 138 ]. The authors also demonstrated that 4-AP significantly decreases vasorelaxation induced by pinacidil in vascular SMCs of HUV from normotensive pregnant subjects, but not in hypertensive pregnant subjects [ 138 ]. Furthermore, the same authors reported in this year (2020) that in hypertension situations, there is a decrease in Kv1.3 channel expression and function in SM of HUV [ 139 ].…”

Section: Clinical Importance and Medical Uses Of K + mentioning

confidence: 99%

“…However, as there were no changes in the MaxiK-α subunit, this regulation does not appear to be the result of an increase in the number of channels. This regulation is likely to be the result of post-transcriptional modifications of the MaxiK-α subunits and/or changes in interaction with auxiliary subunits [ 138 ]. Concerning PE, He et al (2017) reported that BK Ca channel impairment in human CPA is potentially relevant to the development of the pathology.…”

Section: Clinical Importance and Medical Uses Of K + mentioning

confidence: 99%

“…Concerning the K ATP channels, studies have also reported their involvement in gestational pathological processes such as gestational hypertension [ 138 ]. Changes in the function and expression of these channels have already been reported in vascular SMCs of various vascular beds and different species in the presence of this pathology [ 7 , 138 ]. The reduction in the function of the K ATP channels has been implicated in hypertension.…”

Section: Clinical Importance and Medical Uses Of K + mentioning

confidence: 99%

“…Djokic et al (2019) observed in HUV that in situations of gestational hypertension, there was a decrease in the expression of the Kir6.1 pore-forming subunit, while the expression of SUR2B remained unchanged. Exposure of a too-short HUV to the hypertensive environment or the therapeutic application that maintains vascular tension during pregnancy may be possible explanations for the unchanged expression of SUR2B [ 138 ]; not least because a previous study carried out with SM of the aorta of spontaneously hypertensive rats demonstrated that as the exposure time increased, the decrease in expression observed for this subunit was increased [ 188 ]. However, Tajada et al (2012) reported a reduced expression of SUR2B in their investigation, as well as a decrease in the function of K ATP channels that impaired vascular tone [ 166 ].…”

Section: Clinical Importance and Medical Uses Of K + mentioning

confidence: 99%

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Clinical Importance of the Human Umbilical Artery Potassium Channels

Lorigo

Oliveira

2020

Cells

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Potassium (K+) channels are usually predominant in the membranes of vascular smooth muscle cells (SMCs). These channels play an important role in regulating the membrane potential and vessel contractility—a role that depends on the vascular bed. Thus, the activity of K+ channels represents one of the main mechanisms regulating the vascular tone in physiological and pathophysiological conditions. Briefly, the activation of K+ channels in SMC leads to hyperpolarization and vasorelaxation, while its inhibition induces depolarization and consequent vascular contraction. Currently, there are four different types of K+ channels described in SMCs: voltage-dependent K+ (KV) channels, calcium-activated K+ (KCa) channels, inward rectifier K+ (Kir) channels, and 2-pore domain K+ (K2P) channels. Due to the fundamental role of K+ channels in excitable cells, these channels are promising therapeutic targets in clinical practice. Therefore, this review discusses the basic properties of the various types of K+ channels, including structure, cellular mechanisms that regulate their activity, and new advances in the development of activators and blockers of these channels. The vascular functions of these channels will be discussed with a focus on vascular SMCs of the human umbilical artery. Then, the clinical importance of K+ channels in the treatment and prevention of cardiovascular diseases during pregnancy, such as gestational hypertension and preeclampsia, will be explored.

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Section: Clinical Importance and Medical Uses Of K + mentioning

confidence: 99%