Effect of ginseng extract on ribonucleic acid and protein synthesis in rat kidney.

Nagasawa, Tetsuro; Oura, Hikokíchi; Hiai, Susumu; Nishinaga, Keiji

doi:10.1248/cpb.25.1665

Cited by 15 publications

(4 citation statements)

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“…The Siberian ginseng is a different plant, referred to as Eleutherococcus senticosus ginseng. The beneficial health effects of ginseng relate to its transient regulatory effects on carbohydrates, lipids, and nucleic acid metabolism (Nagasawa et al, 1977;Oura and Hiai, 1973;Sotaniemi et al, 1995). It also has a prophylactic effect that reduces susceptibility to illness and may act as an aphrodisiac.…”

Section: Ginsengmentioning

confidence: 99%

Phenolics in Food and Nutraceuticals

Shahidi¹,

Naczk

2003

618

426

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has reached the highest academic level, university research professor, in the department of biochemistry at Memorial University of Newfoundland (MUN). He is also cross-appointed to the department of biology, ocean sciences centre and the aquaculture program at MUN. Dr. Shahidi is the author of nearly 500 research papers and book chapters and has authored or edited over 30 books and made over 300 presentations at scientific conferences. His research contributions have led to several industrial developments around the globe. Dr. Shahidi's current research interests include different areas of nutraceuticals and functional foods as well as marine foods and natural antioxidants.Dr. Shahidi serves as the editor-in-chief of the Journal of Food Lipids and is an editorial board member of

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Section: Ginsengmentioning

confidence: 99%

Phenolics in Food and Nutraceuticals

Shahidi¹,

Naczk

2003

618

426

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“…hi) and various other components (1)(2)(3)(4)(5)(6)(7)(8)(9). Other aspects, such as the pharmacological profile (10)(11)(12)(13)(14), the role of the ginsenoside in metabolism of lipids and sugars (15)(16)(17)(18)(19) and in RXA and protein synthesis (20)(21)(22), are also being investigated. From these studies, the ginsenosides are known to be the active principles in ginseng.…”

mentioning

confidence: 99%

Histochemistry. I. Ginsenosides in Ginseng (Panax ginseng C. A. Meyer, Root)

Kubo¹,

Tani²,

Katsuki³

et al. 1980

J. Nat. Prod.

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“…In addition, Kaneto and Inoue (22) have reported that the development of toler ance to morphine is prevented by an a-blocker, phen tolamine, and a ,8-blocker, propranolol, suggesting an imbalance of central adrenergic systems in the under lying mechanism. Thus, it is suggested that the GE, by improving the general metabolism such as the accelera tion of protein, nucleic acid and lipid syntheses (23,24) and/or by recovering the imbalance of adrenergic sys tems in the CNS, normalizes the adaptability (8) which is impaired by stress exposure.…”

Section: Discussionmentioning

confidence: 99%

Anti-Stress Effect of Ginseng on the Inhibition of the Development of Morphine Tolerance in Stressed Mice.

1992

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We examined how the ginseng extract (GE) acts on the antinociceptive effect induced by footshock (FS)-, psychological (PSY) and forced swimming (SW)-stress (stress-induced analgesia, SIA), and also on the suppression by FS and PSY-stress of the development of tolerance to morphine in mice. Neither an acute treatment nor 5 daily pretreatments with GE at 100 mg/kg, p.o. affected each SIA. Pretreatment with GE at 100 mg/kg, p.o. for 5 days followed by the treatment in combination with the exposure to stresses for another 5 days caused no appreciable changes in the development of tolerance to FS and SW-SIA, but suppressed the development of tolerance to PSY-SIA. When mice were pretreated with GE for 5 days and given GE daily prior to morphine at 10 mg/kg/day, with stress exposure for another 5 days, the inhibitory effect of FS-stress on the development of tolerance to mor phine was completely eliminated. The present results suggest that GE, by improving the general meta bolism in the body, directs toward normalization of the adaptability which is impaired by stress expo sure, while not compromising morphine antinociceptive activity or the SIA, another adaptability pro duced in confrontation to abnormal environmental stimuli. In addition, the differences in the mecha nism underlying the FS and PSY-stress effect which we have previously demonstrated are also recon firmed.Keywords: Ginseng extract, Stress-induced analgesia (SIA), Anti-stress effect, Morphine tolerance, Tolerance to SIA Much interest has been focused on the ginseng sapo nins which have been used medically for thousands of years in Korea, China and Japan because they possess multiple pharmacological actions mediated by the cen tral nervous system, such as suppression of spontaneous movements (1), facilitation of recovery from exhaustion caused by forced running and by swimming (2, 3), psychotropic effects (4, 5) and blockade of tolerance to and dependence on morphine (6, 7). It is also reported that Panax ginseng normalizes physiological disfunction caused by stress exposure, suggesting that ginseng sapo nin may have a non-specific anti-stress effect (8 10). Meanwhile, we have reported (11 13) that exposure to footshock (FS)-, forced swimming (SW) and psycho logical (PSY)-stress produces antinociceptive effect (stress-induced analgesia, SIA) and also that concurrent exposure to FS and PSY-stress but not SW-stress sup presses the development of morphine tolerance, which is generally considered to be an adaptive response.In this context, it is of interest to examine how the ginseng extract acts on various SIAs and the suppres sive effect of FS and PSY-stress on the development of morphine tolerance.

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Effect of ginseng extract on ribonucleic acid and protein synthesis in rat kidney.

Cited by 15 publications

References 0 publications

Phenolics in Food and Nutraceuticals

Phenolics in Food and Nutraceuticals

Histochemistry. I. Ginsenosides in Ginseng (Panax ginseng C. A. Meyer, Root)

Anti-Stress Effect of Ginseng on the Inhibition of the Development of Morphine Tolerance in Stressed Mice.

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