Effect of glidants in binary powder mixtures

Improving Powder Flow Properties of a Cohesive Lactose Monohydrate Powder by Intensive Mechanical Dry Coating

“…As a glidant, FS has been described as having two modes of action: (a) to modify the particle surface morphology and reduce the attractive forces between particles by increasing their contact distance; (b) to act as ball bearings which can reduce the friction forces between particles when they flow 40, 41. It has been suggested that FS may only discretely cover host particle surfaces and tends to form nonuniform coating during the intensive coating process since those nano‐meter size particles tend to form agglomerates 39, 40. In addition, the physical separation provided by these nanoparticles may not be as effective as the hydrophobic boundary provided by the fatty acid.…”

Force control and powder dispersibility of spray dried particles for inhalation

“…The effect that the diameter of curvature influences cohesion in the contact zone is typically associated with a reduction of van‐der‐Waals forces caused by surface roughness or in presence of glidants (force control agents) in powder mixtures 8, 9, 24. In case of corrugated particles contact between particles is preferred at convex areas of the corrugated surface (Fig.…”

Synthesis of -leucine nanoparticles via physical vapor deposition at varying saturation conditions

“…In addition to contact area, the separation of particles also depends on the contact distance between particles, i.e. the size of glidant particles (Jonat, Hasenzahl, Gray, & Schmidt, 2004;Meyer & Zimmermann, 2004).…”