Effect of Glipizide Treatment on Response to an Infused Glucose Load in Patients With NIDDM

Abstract

The results of these calculations indicated that glipizide treatment was associated with a significant increase in fractional glucose metabolic rate at a basal insulin concentration (29 +/- 3 to 42 +/- 2 ml.m-2.min-1, P < 0.001), and in response to the incremental change in SSPI (14 +/- 4 to 23 +/- 3 ml.m-2.min-1, P < 0.02). Finally, SI also increased in association with sulfonylurea (0.24 +/- 0.06 to 0.43 +/- 0.07 ml.m-2.min-1/microU.ml-1, P < 0.001).

Efficacy And Metabolic Effects Of Metformin And Troglitazone In Type II Diabetes Mellitus

“…24,25 The beneficial effect of metformin on glucose disposal, on the other hand, is in the same range as that which occurs in patients treated with sulfonylurea drugs. 26,27 Whether this is a direct effect of metformin or due to an overall decrease in glucose toxicity is not known. 28 The lack of effect of troglitazone at this dose on endogenous glucose production is in contrast to findings by others, 10,12,13 but agrees with the results of a recently reported large, multicenter study.…”

Alterations in non-insulin-mediated glucose uptake in the elderly patient with diabetes.

“…Lowering of FFA levels, exercise conditioning, anabolic steroids, certain oral hypoglycemic agents, and glucagonlike peptide (GLP)-1 all enhance S G in younger patients (8,17, [32][33][34][35][36]. Any or all of these interventions could be of bene fit in the geriatric population.…”