Morning cortisol levels and glucose effectiveness

Fernández‐Real, José‐Manuel; Casamitjana, Roser; Ricart, Wifredo

doi:10.1016/s0026-0495(00)90066-0

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…In the entire group mean serum cortisol decreased below its baseline levels at 90-120 min as described previously during GTT; 6,7 however, in the entire group of normal subjects of our study a small increase of mean serum cortisol occurred at 30 min, which is not described in previous reports. 6,7 In fact, in 50% of the participants mean serum cortisol increased significantly within the normal range of morning serum cortisol, and in the remaining subjects mean serum cortisol decreased significantly during GTT. The reason for these discrepancies is not evident.…”

Section: Discussionsupporting

confidence: 69%

Hyperinsulinemia during oral glucose tolerance test and high normal serum cortisol are associated with increased secretion of calcitonin in normal subjects

Polymeris¹,

Papapetrou²,

Papandroulaki³

et al. 2011

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ObJEctIVE: Previous studies showed that insulin stimulated directly calcitonin (ct) secretion in the pig thyroid, while dexamethasone stimulated the production of ct and ct mrNA in medullary thyroid carcinoma (Mtc) cell lines. the objective of this study was to investigate if hyperinsulinemia during the oral glucose tolerance test (Gtt) stimulates ct secretion in normal subjects as well as to examine the relationship between serum cortisol and ct. DEsIGN: In 26 normal subjects (9 men and 17 women) with detectable basal serum ct, aged 22-70 yr [51.5±14.6 (mean±SD), median 55.5], we measured serum or plasma ct, cortisol, ActH, insulin, and blood glucose before (0 min) and at 30, 60, 90, and 120 min after ingestion of 75 g glucose. rEsULts: During Gtt mean serum cortisol increased slightly by 9.3% at 30 min, whereas mean serum insulin increased 9.4-fold, reaching a peak value at 60 min. Median serum Ct increased by 51% (p<0.001) in normal subjects (by 27% in men, p=0.004, and by 44% in women, p<0.001) at 30 min and remained significantly higher thereafter (up to 120 min) when compared to median baseline level. regression analysis showed that basal serum cortisol, but not basal serum insulin, was correlated with basal serum ct (p=0.01). Peak concentrations of Ct were also correlated with peak concentrations of cortisol at 30 min (p<0.001) but not at later time points. serum insulin was correlated with serum ct at the serum insulin peak level (60 min), and at later time points (90 and 120 min) (p=0.001). Multiple and simple regression analysis showed that calcitonin-AUc (Area Under curve) values correlated with insulin-AUc (p=0.003), and also with cortisol-AUc (p=0.02) values, the standardized effect of insulin-AUc on calcitonin-AUc being greater than that of cortisol-AUc. cONcLUsIONs: these findings suggest that acute hyperinsulinemia during Gtt is very likely associated with increased ct secretion in normal subjects. serum cortisol within the physiological range was also correlated with serum ct under basal conditions, as well as during Gtt.

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Section: Discussionsupporting

confidence: 69%

Hyperinsulinemia during oral glucose tolerance test and high normal serum cortisol are associated with increased secretion of calcitonin in normal subjects

Polymeris¹,

Papapetrou²,

Papandroulaki³

et al. 2011

View full text Add to dashboard Cite

show abstract

“…While in some insulin‐resistant states, NIMGU increases as IMGU declines, we previously demonstrated that in women with PCOS decreased IMGU was not accompanied by a compensatory increase in NIMGU . These data suggest that the absence of a compensatory increase in NIMGU may exacerbate the IR of PCOS.…”

Section: Discussionmentioning

confidence: 78%

“…In some insulin‐resistant states, such as T2DM and adrenocortical hyperactivity, NIMGU increases as insulin sensitivity declines, suggesting that this relationship may be a vital compensatory mechanism to ensure that sufficient glucose uptake in the presence of impaired IMGU. The underlying molecular mechanisms for the bivalent relationship between IGMU and NIGMU are further supported by studies in cultured skeletal muscles of transgenic diabetic mice .…”

Section: Introductionmentioning

confidence: 99%

Adipocyte expression of glucose transporter 1 and 4 in PCOS: Relationship to insulin‐mediated and non–insulin‐mediated whole‐body glucose uptake

Ezeh

Chen

et al. 2019

Clinical Endocrinology

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Background: Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine-metabolic disorder associated with insulin resistance (IR). In IR states, non-insulin-mediated glucose uptake (NIMGU) may increase to compensate for declining insulin-mediated glucose uptake (IMGU), although this does not appear to be the case in PCOS. The underlying molecular mechanisms for this deficiency remain unclear. Objectives: To compare adipocyte glucose transporter 1 and 4 (GLUT-1 and GLUT-4) gene expression in PCOS women and matched controls, and to determine whether changes in GLUT-1 and GLUT-4 are associated with concomitant alterations in wholebody glucose uptake. Research design and methods: In this prospective cross-sectional study, 23 women with PCOS (by NIH 1990 criteria) and 23 matched controls were studied for subcutaneous abdominal adipocyte GLUT-1 and GLUT-4 mRNA expression (by real-time PCR), and basal whole-body IR (by HOMA-IR) and insulin secretion (by HOMA-β%). A subset of six PCOS women and six matched controls also underwent a mFSIVGTT to determine dynamic state glucose uptake (by insulin sensitivity index [Si] and glucose effectiveness [Sg]) and insulin secretion (by the acute insulin response to glucose [AIRg] and the disposition index [Di]).Results: For similar adiposity (BMI and waist-hip ratio), PCOS women tended to have higher HOMA-IR and lower Di and Si, and higher HOMA-β% and lower GLUT-4 than controls, while GLUT-1 was similar. GLUT-1 was positively associated with Sg (reflecting NIMGU) and GLUT-4 positively with Si (reflecting IMGU). GLUT-4 was associated negatively with HOMA-IR and HOMA-β% and positively with Di for the entire cohort but not with AIRg. Both GLUT-1 and GLU-4 were negatively associated with BMI, but not with each other. Conclusion:Our results suggest that IR secondary to a lower IMGU and enhanced insulin secretion in PCOS is in part attributable to a reduction in adipocyte GLUT-4 expression that is not accompanied by a compensatory increase in GLUT-1 expression. K E Y W O R D Sadipocyte GLUT-1, GLUT-4, insulin resistance, polycystic ovary syndrome | 543 EZEH Et al.

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Effects of Endogenous Androgens and Abdominal Fat Distribution on the Interrelationship Between Insulin and Non-Insulin-Mediated Glucose Uptake in Females

Ezeh

Pall

Mathur

et al. 2013

The Journal of Clinical Endocrinology &Amp; Metabolism

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Morning cortisol levels and glucose effectiveness

Cited by 3 publications

References 23 publications

Hyperinsulinemia during oral glucose tolerance test and high normal serum cortisol are associated with increased secretion of calcitonin in normal subjects

Hyperinsulinemia during oral glucose tolerance test and high normal serum cortisol are associated with increased secretion of calcitonin in normal subjects

Adipocyte expression of glucose transporter 1 and 4 in PCOS: Relationship to insulin‐mediated and non–insulin‐mediated whole‐body glucose uptake

Effects of Endogenous Androgens and Abdominal Fat Distribution on the Interrelationship Between Insulin and Non-Insulin-Mediated Glucose Uptake in Females

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