Effect of Gliricidia sepium leaves intake on larval establishment of Cooperia punctata in calves and bio-guided fractionation of bioactive molecules

Fernex, Elke von Son-de; Miguel, Ángel Alonso-Díaz; Mora, Braulio Valles de la; Gives, Pedro Mendoza de; Castillo-Gallegos, Epigmenio; Zamilpa, Alejandro; González-Cortazar, Manasés

doi:10.1016/j.vetpar.2018.02.003

Cited by 9 publications

(6 citation statements)

References 23 publications

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“…These substances have anthelmintic effects on animals and humans. Some legumes found in this study, such as L. leucocephala , Acacia spp., and Gliricidia sepium are known to be tannin-rich forages [ 15 , 16 , 20 , 21 ]. Tannins are one of the most-studied secondary metabolites for their role as natural anthelmintics, especially in small ruminants [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

The diversity and quality of forages and their potency as herbal anthelmintic for swamp buffalo in Brebes District, Central Java

Satrija

Nurhidayah²,

Astuti

et al. 2023

Vet World

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Background and Aim: Swamp buffaloes play an important role in the rural economy of Indonesia. They consume various forages during their grazing time, including those with anti-parasitic potential. However, the information about the type and quality of forages and their potential as a natural anthelmintic for swamp buffalo is very limited. This study aimed to identify the diversity, quality, and anthelmintic potency of forages consumed by swamp buffaloes reared in Bantarkawung Subdistrict, Brebes District, Central Java Province, Indonesia. Materials and Methods: Samples of forages were obtained during three observation periods of the study, with a 12-week interval between each period. Forage diversity was evaluated by identifying its consumption by swamp buffaloes during their grazing activity in the field and feeding time in their shed. The quality of forages was analyzed using proximate analysis to measure their dry matter (DM), crude fiber (CF), crude protein (CP), crude fat (CFat), and ash contents. This is followed by the calculation of their total digestible nutrient based on the proximate analysis results. Botanical composition analysis was then conducted to measure the predominance of forages consumed by the livestock during their grazing activity. Literature reviews were carried out to explore forage’s anthelmintic activity. Results: The results showed that swamp buffaloes consume nine species of forage in the shed and 47 in the grazing area, including nine legumes, 18 grass, and 20 others. Swamp buffaloes consumed forages of lower quality, which contained high CF contents and varying levels of other nutrients below their daily nutritional needs. The grazing activity allowed swamp buffaloes to consume a higher variety of forages with better nutritional quality, thereby enabling them to meet their nutritional needs. Legumes and other forages served as the major protein sources, providing CP of 20.03% DM and 11.53% DM, and CF levels of 17.01% DM and 20.35% DM, respectively. The results also showed that the consumption of these forages increased during the rainy season. The predominant species of legumes consumed were Leucaena leucocephala and Acacia spp., while Alternanthera sessilis and Merremia umbellata were the predominant species of other forages. A total of 13 of the 47 species could potentially be used as natural anthelmintic due to their secondary metabolites, namely, tannin, flavonoid, saponin, terpenoid, diterpenoid, and mimosine. These compounds exert anthelmintic effects by inhibiting egg-hatching and larval development, as well as damaging the surface structure of both larvae and adult worms, ultimately leading to the death of the parasites. Conclusion: Overall, swamp buffaloes consumed more variety of forages during grazing compared to when they were kept in sheds. While the low-variety and low-quality forages provisioned for swamp buffaloes in their shed resulted in a low nutrient intake below their daily requirement. Furthermore, daily grazing activities allowed swamp buffaloes to fulfill and supplement their need by consuming a variety of grasses, legumes, and other forages in their respective grazing areas. Some of these forages also have the potential to become natural anthelmintic because they contain secondary metabolites, such as tannins, flavonoids, saponins, terpenoids, diterpenoids, and mimosine. Keywords: forages, herbal anthelmintics, Indonesia, nutrition, pastoral, swamp buffalo.

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Section: Discussionmentioning

confidence: 99%

The diversity and quality of forages and their potency as herbal anthelmintic for swamp buffalo in Brebes District, Central Java

Satrija

Nurhidayah²,

Astuti

et al. 2023

Vet World

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“…The purified protease inhibited both the development and exsheathment of H. contortus larvae, with 50% effective concentrations of 260 and 790 µg/mL, respectively [83]. Kaempferol 3-O-rhamnopyranosyl-(1→6)-β-D-glucopyranoside-7-O-rhamnopyranoside (oxytroside), isolated from Gliricidia sepium leaves by bioassay-guided purification, fully inhibited Cooperia punctata exsheathment (2400 µg/mL) in calves [84].…”

Section: Natural Products Active Against Intestinal Parasitic Nematodesmentioning

confidence: 99%

Plant-Based Natural Products for the Discovery and Development of Novel Anthelmintics against Nematodes

2020

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Intestinal parasitic nematodes infect approximately two billion people worldwide. In the absence of vaccines for human intestinal nematodes, control of infections currently relies mainly on chemotherapy, but resistance is an increasing problem. Thus, there is an urgent need for the discovery and development of new anthelmintic drugs, especially ones with novel mechanisms of action. Medicinal plants hold great promise as a source of effective treatments, including anthelmintic therapy. They have been used traditionally for centuries and are mostly safe (if not, their toxicity is well-known). However, in most medicinal plants the compounds active against nematodes have not been identified thus far. The free-living nematode C. elegans was demonstrated to be an excellent model system for the discovery of new anthelmintics and for characterizing their mechanism of action or resistance. The compounds discussed in this review are of botanical origin and were published since 2002. Most of them need further studies of their toxicity, mechanisms and structure-activity relationship to assess more fully their potential as drugs.

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“…Metabolite 85 had the highest ovicidal effect (EC 50 of 0.024 mg/mL), EHI, and embryonic development against C. puntacta [84]. A second metabolite isolated from the leaves of G. sepium was identified as oxytroside ( 86 ) which inhibited the C. punctata exsheathment process at 2400 µg/mL (Table 21, Figure 12) [85].…”

Section: Nematicidal Compounds and Plant Extractsmentioning

confidence: 99%

Insecticidal and Nematicidal Contributions of Mexican Flora in the Search for Safer Biopesticides

Hernández-Carlos

Gamboa‐Angulo

2019

Molecules

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Plant metabolites have been used for many years to control pests in animals and to protect crops. Here, we reviewed the available literature, looking for the species of Mexican flora for which extracts and metabolites have shown activity against pest insects and parasitic nematodes of agricultural importance, as well as against nematodes that parasitize domestic cattle. From 1996 to 2018, the search for novel and eco-friendly biopesticides has resulted in the identification of 114 species belonging to 36 botanical families of Mexican plants with reported biological effects on 20 insect species and seven nematode species. Most plant species with detected pesticide properties belong to the families Asteraceae, Fabaceae, and Lamiaceae. Eighty-six metabolites have been identified as pesticidal active principles, and most have been terpenoids. Therefore, the continuation and intensification of this area of research is very important to contribute to the generation of new products that will provide alternatives to conventional pesticide agents. In addition, future studies will contribute to the recognition and dissemination of the importance of propagating plant species for their conservation and sustainable use.

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Effect of Gliricidia sepium leaves intake on larval establishment of Cooperia punctata in calves and bio-guided fractionation of bioactive molecules

Cited by 9 publications

References 23 publications

The diversity and quality of forages and their potency as herbal anthelmintic for swamp buffalo in Brebes District, Central Java

The diversity and quality of forages and their potency as herbal anthelmintic for swamp buffalo in Brebes District, Central Java

Plant-Based Natural Products for the Discovery and Development of Novel Anthelmintics against Nematodes

Insecticidal and Nematicidal Contributions of Mexican Flora in the Search for Safer Biopesticides

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