Effect of glucagon on gastric and pancreatic secretion and peptic ulcer formation in cats

Konturek, Stanisław J.; Demitrescu, Teresa; Radecki, T; Thor, Piotr; Pucher, Anna

doi:10.1007/bf01072743

Cited by 40 publications

(15 citation statements)

References 25 publications

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“…Then the gastric fistula was opened and the stomach washed out with tap water. Gastric secretion was collected at half-hour intervals, the volume was noted and the hydrogen ion and pepsin concetrations and outputs were determined as described previously (Konturek, Demitrescu & Radecki, 1974). Two types of secretary studies were performed, one with saline (control) or EGF infused subcutaneously (s.c.) and another with saline or EGF given intragastrically (I.G.).…”

Section: Introductionmentioning

confidence: 99%

Trophic action of epidermal growth factor on the pancreas and gastroduodenal mucosa in rats.

Dembiński¹,

Gregory²,

Konturek³

et al. 1982

The Journal of Physiology

201

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SUMMARY1. Epidermal growth factor (EGF) infused subcutaneously in a dose of 10 ,g/kg . h but not 1 jug/kg . h inhibited spontaneous gastric acid and pepsin secretion, whereas when given intragastrically in a dose of 10 jug/kg . h it failed to affect this secretion.2. EGF injected intraperitoneally at 8 h intervals for 24 h significantly stimulated DNA synthesis in the gastroduodenal mucosa and the pancreas, whereas when administered intragastrically it stimulated DNA synthesis only in the gastroduodenal mucosa but not in the pancreas.3. Chronic parenteral administration of EGF significantly increased the DNA and RNA contents of the gastroduodenal mucosa and the pancreas.4. This study demonstrates that parenteral EGF is a potent inhibitor of gastric secretion and trophic agent for the gastroduodenal mucosa and pancreas, and that the gastric inhibitory and trophic effects of EGF are the results of two separate mechanisms.

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Section: Introductionmentioning

confidence: 99%

Trophic action of epidermal growth factor on the pancreas and gastroduodenal mucosa in rats.

Dembiński¹,

Gregory²,

Konturek³

et al. 1982

The Journal of Physiology

201

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“…In the first series of experiments performed on 46 cats, the mucosal con tents of PGE2 and PG12 were measured under various conditions. In the second series, the effects of PGE2 on gastric secretion induced by histamine was exam ined in 6 cats provided with chronic gastric fistula (GF) prepared according to the method described previously (16). In addition each animal was fitted with a sling of plastic tubing (polyvinyl chloride, 0.5 mm outside diameter) around the pylorus which was brought out through the body wall by means of a small plastic cannula.…”

Section: Methodsmentioning

confidence: 99%

Prostaglandin E<sub>2</sub> in Gastric Mucosa and Its Role in the Prevention of Ulcers Induced by Acetyl Salicylic Acid in Cats

Konturek¹,

Radecki²,

Brzozowski³

et al. 1981

Digestion

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Gastric mucosa of the cat generates PGE₂ activity at a significantly higher concentration in the antral 59.25 ± 7.42 ng/g) than in the oxyntic (28.06 ± 4.50 ng/ml) gland area. Intravenous (i.v.) infusion of histamine (80 μg/kg/h) or intragastric (i.g.) instillation of 0.1 N HCl (4 mEq/h) for 3 h significantly decreased the generation of PGE₂ in antral and fundic mucosa, but did not result in the formation of gastric lesions. Aspirin (ASA) given i.v. or i.g. for 3 h caused a further fall in the generation of PGE₂ in the mucosa and when combined with i.v. histamine or i.g. HCl, it caused almost complete disappearance of PGE₂ activity and the formation of antral ulcers in all tested cats. Exogenous PGE₂ given i.v. in a dose (30 μg/kg/h) reducing histamine-stim-ulated (80 μg/kg/h) acid secretion by about 50%, prevented almost completely the formation of gastric ulcers induced by a combination of ASA plus i.v. histamine or i.g. HCl. This study indicates that the gastric mucosa generates PGE₂ which is capable of preventing gastric ulcers induced by ASA combined with histamine or mucosal acidification.

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“…Six cats, weighing 2.5-3.5 kg, were prepared surgically with chronic gastric (GF) and pancreatic fistula (PF) performed according to a method described previously (12). Secretory studies were started about 6 months after the surgery.…”

Section: Methodsmentioning

confidence: 99%

“…Gastric acid responses to peptone meal were measured by the intragastric titration as described previously (12). The rate of intragastric infusion of biocarbonate from the auto burette was automatically adjusted by titration as necessary to maintain the gastric pH constant at pH 5.0.…”

Section: Methodsmentioning

confidence: 99%

“…The volume of gastric juice was recorded and acid output was determined by titration as described previously (12). The pepsin concentration was determined using a modification (17) of Anson's (2) hemoglobin method and expressed as milligrams of pepsin per milliliter by reading the trichloracetic acid supernate at 280 nm and comparing it with solutions incubated with different pepsin standards (Hog pepsin.…”

Section: Methodsmentioning

confidence: 99%

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Comparison of Natural and Synthetic Prostaglandins on Gastric and Pancreatic Secretions and Peptic Ulcer Formation in Conscious Cats

Konturek¹,

Radecki²,

Pucher³

1976

Digestion

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In conscious cats with chronic gastric and pancreatic fistulas, the natural prostaglandins (PGs) of the E (PGE₁ and PGE₂) and F (PGF_1α and PGF_2α) series and synthetic 15-methyl analog of PGE₂, 15(S) 15-methyl-PGE₂methylester were compared with regard to their action on gastric and pancreatic secretions and peptic ulcer formation. This study indicates that in comparison with natural PGs, the synthetic 15-methyl analog of PGE₂ is a more potent inhibitor of gastric secretion regardless of the route of administration and the mode of gastric stimulation. It more effectively prevents the formation of peptic ulcers in conscious cats.

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Effect of glucagon on gastric and pancreatic secretion and peptic ulcer formation in cats

Cited by 40 publications

References 25 publications

Trophic action of epidermal growth factor on the pancreas and gastroduodenal mucosa in rats.

Trophic action of epidermal growth factor on the pancreas and gastroduodenal mucosa in rats.

Prostaglandin E<sub>2</sub> in Gastric Mucosa and Its Role in the Prevention of Ulcers Induced by Acetyl Salicylic Acid in Cats

Comparison of Natural and Synthetic Prostaglandins on Gastric and Pancreatic Secretions and Peptic Ulcer Formation in Conscious Cats

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