Effect of Glucose on Growth Hormone, Prolactin and Thyroid-Stimulating Hormone Response to Diazepam in Normal Subjects

Ajlouni, Kamel; El-Khateeb, Mohammed

doi:10.1159/000179282

Cited by 17 publications

(10 citation statements)

References 6 publications

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“…Ad ministration of 10 mg diazepam i.v. or orally failed to affect prolactin or TSH secretion, in agreement with several studies examining the effects of oral diazepam on thyroid function and prolactin release [4][5][6][13][14][15].…”

Section: Discussionsupporting

confidence: 88%

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Failure to Confirm Consistent Stimulation of Growth Hormone by Diazepam

Levin

Sharp

Carlson³

1984

Horm Res

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Diazepam has been reported to influence pituitary hormone secretion, with several studies claiming that diazepam provokes growth hormone release. Normal volunteers were therefore examined for anterior pituitary responsiveness to 10 mg diazepam i.v. and p.o. The drug had no significant effect on the secretion of prolactin or thyrotropin when compared to control saline injections in all subjects. Growth hormone response was variable; serum growth hormone increased significantly in only 4 of 10 patients after i.v. diazepam and in only 1 of 7 subjects tested with oral diazepam. Serum cortisol rose in only 1 subject, precluding a stress-related explanation for the increase in growth hormone. We conclude that diazepam inconsistently stimulates growth hormone secretion and should not be relied upon as a test of growth hormone reserve.

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Section: Discussionsupporting

confidence: 88%

“…Other studies [3,4] re porting diazepam-induced GH secretion did use indwelling venous catheters with an equilibration period between venous cathe terization and drug administration. We have no explanation for our failure to confirm these reports other than to suggest inherent differences in subjects or in the GH radioim munoassays used.…”

Section: Discussionmentioning

confidence: 99%

Failure to Confirm Consistent Stimulation of Growth Hormone by Diazepam

Levin

Sharp

Carlson³

1984

Horm Res

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“…For alprazolam, it has been suggested that the antipanic mechanism of action may be due, in part, to an interaction between the benzodiazepine re ceptors and the noradrenergic neural system [3] or due to an aIpha-2-agonistic effect [10], Measurements of plasma hormones following a cen trally active pharmacological challenge are commonly used as possible marker for involvement of central neu rotransmitter systems. Benzodiazepines have been shown to consistently raise growth hormone (GH) [11][12][13] and reduce ACTH and cortisol [14. 15].…”

Section: Introductionmentioning

confidence: 99%

Neuroendocrine and Monoaminergic Responses to Acute Administration of Alprazolam in Normal Subjects

et al. 1990

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The effect of a single dose (3 mg) of alprazolam on plasma cortisol, growth hormone (GH), prolactin, norepinephrine (NE) and 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) was studied in 10 healthy males. Alprazolam and placebo were administered orally in a crossover design and blood was sampled for 24 h. In comparison to placebo, alprazolam significantly reduced plasma cortisol levels and raised plasma GH levels. Prolactin levels were elevated by 100% from 2 to 8 h after alprazolam administration. The robust increase in prolactin levels is less consistent with previously reported data on traditional benzodiazepines. Plasma NE levels following alprazolam were lower than following placebo administration only at one time point, and MHPG concentrations were not affected. The lack of change in NE and MHPG levels suggests that the acute effect of alprazolam in normal subjects is not mediated via the central noradrenergic system.

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“…While the response of prolactin to diazepam in acromegalics is similar to that in normals [8], GH response was different from normals in whom it induces a rise! It is possible that the lack of stimulation in acromegalics is due to the high GH levels exerting a negative feedback.…”

Section: Discussionmentioning

confidence: 77%

“…The effect of diazepam on TSH and prolactin remained controversial [3][4][5][6][7] until a recent report, which demonstrated no altera tion of TSH and prolactin levels after oral administration of diazepam [8]. While GH rise after diazepam is abolished by hypergly cemia in normals [8], endogenous hypergly cemia of diabetes failed to abolish the re sponse of GH to diazepam [9].…”

Section: Introductionmentioning

confidence: 99%

Failure of Diazepam to Affect Growth Hormone and Prolactin in Acromegalics

Ajlouni¹

1983

Horm Res

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To demonstrate the effect of diazepam on serum growth hormone and prolactin levels in acromegaly, 7 acromegalics were studied. Every patient received 10 mg diazepam orally at zero time, and blood samples were obtained at 30-min intervals. The same patients also underwent a standard L-dopa test. They were given 500 mg L-dopa orally at zero time, and blood samples were obtained at 30-min intervals. The administration of diazepam did not induce any significant changes in either growth hormone or prolactin levels. On the other hand, the administration of L-dopa resulted in a significant decrease in growth hormone level from 74.25 ± 22 ng/ml (mean ± SEM) at zero time to a level of 52.8 ± 21 and 58.77 ± 22.7 ng/ml at the 60- and 90-min intervals, respectively (p < 0.05), and a significant decrease in prolactin level from a baseline of 56.18 ± 17 to 25.5 ± 8.4 ng/ml (p < 0.001) at the 60-min interval.It is suggested that the response of growth hormone to diazepam in acromegalics is qualitatively different from nonacromegalic controls.

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Effect of Glucose on Growth Hormone, Prolactin and Thyroid-Stimulating Hormone Response to Diazepam in Normal Subjects

Cited by 17 publications

References 6 publications

Failure to Confirm Consistent Stimulation of Growth Hormone by Diazepam

Failure to Confirm Consistent Stimulation of Growth Hormone by Diazepam

Neuroendocrine and Monoaminergic Responses to Acute Administration of Alprazolam in Normal Subjects

Failure of Diazepam to Affect Growth Hormone and Prolactin in Acromegalics

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