2012
DOI: 10.2337/dc11-1607
|View full text |Cite
|
Sign up to set email alerts
|

Effect of Glycemic Control on Sudomotor Denervation in Type 2 Diabetes

Abstract: OBJECTIVESudomotor symptoms are a common component of diabetic autonomic neuropathy, but the pathology of sudomotor innervation and its relationship with glycemic control have remained obscured.RESEARCH DESIGN AND METHODSWe enrolled 42 patients (26 males and 16 females aged 56.64 ± 12.67 years) with diabetic neuropathy defined by symmetric distally predominant sensory symptoms, abnormal nerve conduction studies, and reduced intraepidermal nerve fiber density in the leg. Skin biopsies of the distal leg were imm… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
42
0
2

Year Published

2013
2013
2020
2020

Publication Types

Select...
4
2
1

Relationship

0
7

Authors

Journals

citations
Cited by 47 publications
(45 citation statements)
references
References 29 publications
1
42
0
2
Order By: Relevance
“…To make the sweat glands clear for quantifying sweat gland area as the denominator of SGII, we performed PGP 9.5 immunohistochemistry and counterstained with Congo red for sweat glands 9. In the dermis of the control skin, sweat glands appeared as red coils and sudomotor nerves were demonstrated with dense PGP 9.5 + fibers forming linear and varicose patterns circling the secretary coils of sweat glands (Fig 4A).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…To make the sweat glands clear for quantifying sweat gland area as the denominator of SGII, we performed PGP 9.5 immunohistochemistry and counterstained with Congo red for sweat glands 9. In the dermis of the control skin, sweat glands appeared as red coils and sudomotor nerves were demonstrated with dense PGP 9.5 + fibers forming linear and varicose patterns circling the secretary coils of sweat glands (Fig 4A).…”
Section: Resultsmentioning
confidence: 99%
“…However, there was limited pathologic evidence demonstrating the denervation of autonomic targets, such as a report on postmortem tissues, which showed amyloid depositions and neuronal cell loss in sympathetic ganglia with microscopic resolution 2, 30. Sweat gland innervation was reduced in type 2 diabetic neuropathy,6, 7, 9 and we have documented that this reduction of SGIIPGP 9.5 was attributed to sudomotor nerve degeneration as demonstrated at the ultrastructural level 6. The current report is the first to provide direct pathologic evidence of sudomotor denervation in FAP.…”
Section: Discussionmentioning
confidence: 99%
“…Most of the effect of diabetes on the regulation of BT appeared to be associated with the presence of autonomic nervous neuropathy. 25 In previously reported studies it was shown that the regulation of vascular tones was impaired by the injured autonomic nerves and that defective sweating also resulted from the autonomic disorders in subjects with diabetes. 26-30 Therefore, these mechanisms can interfere with the relationship between vascular function and BT in diabetes.…”
Section: Discussionmentioning
confidence: 99%
“…The primary factors associated with this modulation in sweating include long-term diabetes, poorly controlled glycemia, and the presence of neuropathy. Diabetic neuropathy seems to have an important role in altering the sweat gland innervations [68,75]. Luo et al [75,76] showed that the sweat glands in type 2 diabetics with poor glycemic control exhibit exacerbated reductions in periglandular nerve terminals and in the innervation index.…”
Section: The Mechanisms Underlying Type 2 Diabetes-related Impairmentmentioning
confidence: 99%
“…Diabetic neuropathy seems to have an important role in altering the sweat gland innervations [68,75]. Luo et al [75,76] showed that the sweat glands in type 2 diabetics with poor glycemic control exhibit exacerbated reductions in periglandular nerve terminals and in the innervation index. Impairments in sweating during heat stress may also be related to the reduction in nitric oxide bioavailability since the role of nitric oxide-induced sweating during exercise has recently been proven [77,78].…”
Section: The Mechanisms Underlying Type 2 Diabetes-related Impairmentmentioning
confidence: 99%