Effect of glycosaminoglycans on the structure and composition of articular cartilage and bone of broilers

Martins, Julyana M.S.; Neto, Lindolfo Dorcino dos Santos; Sgavioli, Sarah; Araújo, Itallo Conrado Sousa de; Reis, Ângela Adamski da Silva; Santos, Rodrigo Silva; Araújo, Eugênio Gonçalves de; Leandro, Nadja Susana Mogyca; Café, Marcos Barcelos

doi:10.1016/j.psj.2023.102916

Cited by 3 publications

(2 citation statements)

References 35 publications

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Section: Discussionmentioning

confidence: 99%

“…Aminoglycans, a more general term for glycosaminoglycans, promote bone and joint healing [45]. Research is also being conducted to promote the structural development of bones and joints by incorporating glycosaminoglycans into feed [46]. The enrichment of the “Aminoglycan catabolic proc.” term in the enrichment analysis using the gene set upregulated in chickens may reflect the weakness of chicken bones and locomotor disorders.…”

Section: Discussionmentioning

confidence: 99%

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Transcriptional Signatures of Domestication Revealed by Meta-Analysis of Pig, Chicken, Wild Boar, and Red Junglefowl Gene Expression Data

Uno,

Bono

2024

Preprint

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Domesticated animals have undergone significant changes in their behavior, morphology, and physiological functions during domestication. To identify the changes in gene expression associated with domestication, we collected RNA-seq data of pigs, chickens, wild boars, and red junglefowl from public databases and performed a meta-analysis. Gene expression was quantified and the expression ratio between domesticated animals and their wild ancestors (DW-ratio) was calculated. Genes were classified as "upregulated," "downregulated," or "unchanged" based on their DW-ratio, and DW-score was calculated for each gene. Gene set enrichment analysis revealed that genes upregulated in pigs were related to defense from viral infection, whereas those upregulated in chickens were associated with aminoglycan and carbohydrate derivative catabolic processes. Genes commonly upregulated in pigs and chickens are involved in the immune response, olfactory learning, epigenetic regulation, cell division, and extracellular matrix. In contrast, genes upregulated in wild boar and red junglefowl are related to stress response, cell proliferation, cardiovascular function, neural regulation, and energy metabolism. These findings provide valuable insights into the genetic basis of the domestication process and highlight potential candidate genes for breeding applications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Transcriptional Signatures of Domestication Revealed by Meta-Analysis of Pig, Chicken, Wild Boar, and Red Junglefowl Gene Expression Data

Uno,

Bono

2024

Preprint

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Effects of dietary glucosamine sulfate sodium on early laying performance and eggshell quality of laying hens

Wang,

Huang,

Zhou

et al. 2024

Poultry Science

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Transcriptional Signatures of Domestication Revealed through Meta-Analysis of Pig, Chicken, Wild Boar, and Red Junglefowl Gene Expression Data

Uno,

Bono

2024

Animals

View full text Add to dashboard Cite

Domesticated animals have undergone significant changes in their behavior, morphology, and physiological functions during domestication. To identify the changes in gene expression associated with domestication, we collected the RNA-seq data of pigs, chickens, wild boars, and red junglefowl from public databases and performed a meta-analysis. Gene expression was quantified, and the expression ratio between domesticated animals and their wild ancestors (DW-ratio) was calculated. Genes were classified as “upregulated”, “downregulated”, or “unchanged” based on their DW-ratio, and the DW-score was calculated for each gene. Gene set enrichment analysis revealed that genes upregulated in pigs were related to defense from viral infection, whereas those upregulated in chickens were associated with aminoglycan and carbohydrate derivative catabolic processes. Genes commonly upregulated in pigs and chickens are involved in the immune response, olfactory learning, epigenetic regulation, cell division, and extracellular matrix. In contrast, genes upregulated in wild boar and red junglefowl are related to stress response, cell proliferation, cardiovascular function, neural regulation, and energy metabolism. These findings provide valuable insights into the genetic basis of the domestication process and highlight potential candidate genes for breeding applications.

show abstract

Effect of glycosaminoglycans on the structure and composition of articular cartilage and bone of broilers

Cited by 3 publications

References 35 publications

Transcriptional Signatures of Domestication Revealed by Meta-Analysis of Pig, Chicken, Wild Boar, and Red Junglefowl Gene Expression Data

Transcriptional Signatures of Domestication Revealed by Meta-Analysis of Pig, Chicken, Wild Boar, and Red Junglefowl Gene Expression Data

Effects of dietary glucosamine sulfate sodium on early laying performance and eggshell quality of laying hens

Transcriptional Signatures of Domestication Revealed through Meta-Analysis of Pig, Chicken, Wild Boar, and Red Junglefowl Gene Expression Data

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